GREMLIN Database
DUF4149 - Domain of unknown function (DUF4149)
PFAM: PF13664 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 102 (97)
Sequences: 11793 (7925)
Seq/√Len: 804.7
META: 0.918

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_L33_V3.3021.00
29_L32_A2.5821.00
26_P29_L2.4941.00
84_V88_V2.4401.00
83_L87_F2.3351.00
36_R40_R2.2731.00
9_G41_Y2.1171.00
24_V36_R2.0991.00
20_A40_R2.0391.00
92_R95_A2.0371.00
90_Q94_A2.0101.00
12_F17_V1.8251.00
51_V55_T1.6891.00
20_A36_R1.5811.00
11_L15_F1.5611.00
2_A55_T1.5371.00
44_L48_C1.4651.00
2_A48_C1.4621.00
28_E32_A1.4611.00
42_F85_S1.4361.00
6_W45_G1.4111.00
25_L33_V1.4111.00
5_L8_G1.3921.00
27_R30_A1.3901.00
20_A24_V1.3621.00
39_P42_F1.3531.00
17_V37_L1.3531.00
9_G12_F1.3401.00
64_R68_F1.3371.00
22_F38_F1.3331.00
32_A36_R1.3251.00
94_A98_A1.3071.00
12_F16_V1.2821.00
88_V92_R1.2651.00
49_G79_L1.2631.00
90_Q93_M1.2391.00
63_G67_R1.2161.00
43_W47_V1.2031.00
7_L10_L1.1841.00
4_A11_L1.1831.00
33_V37_L1.1761.00
63_G66_R1.1711.00
39_P43_W1.1661.00
21_L34_V1.1631.00
21_L30_A1.1371.00
63_G68_F1.1311.00
5_L11_L1.1201.00
46_L87_F1.1071.00
65_G68_F1.1051.00
18_A34_V1.0951.00
85_S90_Q1.0941.00
71_R74_L1.0921.00
36_R39_P1.0791.00
18_A22_F1.0611.00
21_L37_L1.0541.00
61_L64_R1.0471.00
6_W48_C1.0441.00
92_R96_L1.0281.00
13_F41_Y1.0101.00
45_G82_T1.0101.00
42_F90_Q0.9921.00
68_F71_R0.9801.00
14_G18_A0.9761.00
39_P86_Q0.9671.00
73_L77_L0.9591.00
70_A73_L0.9271.00
43_W86_Q0.9151.00
35_G94_A0.8961.00
9_G44_L0.8951.00
94_A97_R0.8941.00
95_A98_A0.8841.00
26_P30_A0.8401.00
46_L50_A0.8211.00
70_A74_L0.8151.00
55_T59_R0.8121.00
10_L42_F0.8001.00
25_L29_L0.7961.00
17_V21_L0.7831.00
56_L60_A0.7731.00
26_P32_A0.7721.00
7_L11_L0.7621.00
52_L75_L0.7611.00
84_V89_L0.7561.00
41_Y45_G0.7511.00
86_Q90_Q0.7501.00
62_G65_G0.7431.00
6_W78_M0.7341.00
20_A37_L0.7261.00
13_F34_V0.7261.00
46_L86_Q0.7201.00
34_V38_F0.7111.00
24_V32_A0.7101.00
6_W49_G0.6911.00
47_V50_A0.6891.00
74_L78_M0.6881.00
56_L72_L0.6871.00
40_R44_L0.6861.00
14_G42_F0.6851.00
43_W46_L0.6811.00
22_F30_A0.6791.00
35_G39_P0.6721.00
2_A52_L0.6721.00
42_F45_G0.6581.00
31_G34_V0.6551.00
81_L85_S0.6451.00
61_L65_G0.6391.00
77_L81_L0.6311.00
45_G49_G0.6191.00
4_A7_L0.6181.00
15_F19_P0.6181.00
43_W87_F0.6171.00
61_L68_F0.6131.00
23_A40_R0.6131.00
9_G48_C0.6101.00
54_L58_L0.6071.00
56_L59_R0.6051.00
62_G68_F0.6041.00
69_R72_L0.6011.00
80_A84_V0.6011.00
26_P34_V0.5941.00
18_A21_L0.5881.00
61_L66_R0.5871.00
60_A68_F0.5821.00
20_A23_A0.5771.00
84_V92_R0.5761.00
62_G66_R0.5721.00
57_L60_A0.5681.00
31_G35_G0.5541.00
53_L76_L0.5381.00
3_L52_L0.5351.00
75_L85_S0.5301.00
31_G97_R0.5281.00
23_A36_R0.5251.00
56_L71_R0.5251.00
22_F31_G0.5241.00
42_F86_Q0.5211.00
67_R70_A0.5151.00
93_M96_L0.5131.00
3_L7_L0.5071.00
20_A33_V0.5071.00
46_L83_L0.5051.00
27_R35_G0.5041.00
17_V34_V0.5041.00
10_L14_G0.5021.00
4_A9_G0.5021.00
21_L25_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xnjA 1 0.8137 5.4 0.886 Contact Map
4tphA 2 0.8431 4.5 0.89 Contact Map
2cfqA 1 0.9412 4.3 0.891 Contact Map
4k1cA 4 0.8039 4.2 0.891 Contact Map
4k0jA 3 0.8725 4 0.893 Contact Map
3ne5A 3 0.951 3.7 0.895 Contact Map
3w9iA 3 0.9608 3.6 0.895 Contact Map
4uvmA 1 0.951 3.6 0.895 Contact Map
4b4aA 1 0.8137 3.4 0.897 Contact Map
4mt1A 3 0.9216 3.4 0.897 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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