GREMLIN Database
DUF4148 - Domain of unknown function (DUF4148)
PFAM: PF13663 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 58 (53)
Sequences: 3024 (2059)
Seq/√Len: 282.9
META: 0.64

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_L27_E2.8131.00
25_R29_V2.5671.00
27_E30_Q2.5261.00
27_E31_L2.3471.00
28_L32_E2.0051.00
29_V33_Q1.8321.00
23_Q26_A1.7151.00
53_E57_A1.6531.00
40_G43_D1.6351.00
29_V32_E1.4951.00
44_T48_D1.4281.00
7_P10_A1.4011.00
30_Q34_A1.3871.00
19_L23_Q1.3771.00
31_L36_Y1.3521.00
31_L53_E1.3471.00
31_L49_I1.2881.00
8_A11_F1.2821.00
30_Q33_Q1.2771.00
31_L37_N1.2621.00
23_Q27_E1.2551.00
51_A55_R1.2431.00
21_R24_V1.2381.00
52_A55_R1.1751.00
21_R25_R1.0931.00
5_A9_A1.0891.00
26_A30_Q1.0841.00
7_P11_F1.0511.00
6_A9_A1.0491.00
11_F15_Q1.0141.00
47_A50_Q1.0111.00
44_T47_A1.0101.00
39_A42_D1.0061.00
37_N40_G0.9951.00
32_E38_P0.9911.00
19_L24_V0.8881.00
11_F14_A0.8741.00
31_L34_A0.8521.00
6_A10_A0.8371.00
32_E37_N0.8211.00
4_L9_A0.8191.00
34_A56_V0.8140.99
38_P42_D0.7830.99
41_G48_D0.7740.99
42_D48_D0.7700.99
26_A29_V0.7630.99
14_A17_T0.7570.99
7_P15_Q0.7220.99
5_A8_A0.7130.99
22_A26_A0.7100.99
53_E56_V0.6860.98
38_P43_D0.6810.98
49_I53_E0.6800.98
54_A57_A0.6770.98
40_G48_D0.6730.98
6_A11_F0.6660.98
22_A25_R0.6490.97
19_L31_L0.6480.97
52_A56_V0.6300.97
39_A48_D0.6190.97
10_A14_A0.6090.96
40_G44_T0.6080.96
37_N44_T0.5990.96
18_P21_R0.5920.96
6_A16_S0.5880.96
48_D52_A0.5880.96
49_I52_A0.5850.95
25_R32_E0.5810.95
4_L7_P0.5640.94
47_A54_A0.5630.94
28_L45_Y0.5600.94
47_A51_A0.5560.94
8_A15_Q0.5500.94
32_E39_A0.5400.93
34_A37_N0.5390.93
46_P49_I0.5350.93
31_L46_P0.5320.93
36_Y50_Q0.5090.91
33_Q56_V0.5010.90
3_A8_A0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3go6A 4 0.5345 8.3 0.816 Contact Map
3i4eA 4 0.6724 4.1 0.841 Contact Map
4rhjA 3 0.1897 3.3 0.848 Contact Map
2nocA 1 0.931 2.8 0.853 Contact Map
3oi8A 2 0.7069 2.7 0.855 Contact Map
1rp3B 1 0.9138 2.1 0.864 Contact Map
2jnaA 2 0.9655 2 0.865 Contact Map
2ma4A 1 0.7241 1.9 0.866 Contact Map
2jerA 4 1 1.9 0.866 Contact Map
2dcnA 5 0.5345 1.8 0.868 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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