GREMLIN Database
DKNYY - DKNYY family
PFAM: PF13644 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 169 (164)
Sequences: 1837 (1422)
Seq/√Len: 111.1
META: 0.846

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_E34_K4.3111.00
133_N140_K3.6521.00
19_D36_K3.5801.00
50_D53_T3.3751.00
64_D69_Y3.2751.00
150_K160_K3.2741.00
121_E129_K3.2311.00
19_D22_T3.1621.00
120_F128_A3.1191.00
145_D162_K3.0111.00
116_D131_K2.8721.00
7_N14_K2.8321.00
145_D148_T2.8171.00
38_N45_K2.4771.00
149_F159_A2.3971.00
116_D119_T2.3451.00
94_D97_N2.2441.00
22_T36_K2.2001.00
119_T131_K2.1771.00
134_V146_P2.0841.00
39_V51_P1.9491.00
4_D7_N1.9111.00
18_A33_A1.8701.00
94_D99_Y1.8601.00
134_V144_A1.8291.00
83_F87_G1.8061.00
83_F86_L1.7751.00
23_F33_A1.7691.00
22_T35_D1.7551.00
148_T161_D1.6891.00
98_V117_P1.6461.00
64_D68_V1.6411.00
141_L144_A1.5651.00
158_Y165_V1.5461.00
51_P54_F1.5161.00
84_E87_G1.4681.00
25_V33_A1.4671.00
8_V20_P1.4671.00
63_K68_V1.4381.00
49_A53_T1.4191.00
26_L34_K1.3681.00
91_Y128_A1.3611.00
119_T130_D1.3501.00
158_Y167_Y1.3461.00
148_T162_K1.3381.00
49_A54_F1.3070.99
19_D35_D1.3070.99
15_I33_A1.2820.99
8_V18_A1.2780.99
127_Y159_A1.2730.99
144_A159_A1.2430.99
74_N77_D1.2320.99
116_D120_F1.2000.99
15_I18_A1.1700.99
82_S86_L1.1430.99
18_A38_N1.1430.99
115_A119_T1.1350.99
102_D105_K1.1290.98
82_S85_V1.1230.98
141_L159_A1.1070.98
144_A149_F1.0990.98
73_G76_L1.0990.98
18_A23_F1.0940.98
15_I40_Y1.0830.98
129_K132_N1.0830.98
1_Y43_G1.0810.98
107_I110_K1.0690.98
46_L49_A1.0610.98
115_A120_F1.0590.98
63_K69_Y1.0480.97
91_Y138_G1.0420.97
81_E84_E1.0370.97
164_N167_Y1.0260.97
86_L89_N1.0250.97
18_A22_T1.0160.97
151_V159_A1.0040.97
20_P23_F1.0040.97
65_G68_V1.0010.97
98_V128_A0.9980.97
94_D98_V0.9760.96
75_S78_N0.9690.96
116_D132_N0.9540.96
144_A148_T0.9460.95
20_P33_A0.9350.95
98_V115_A0.9250.95
61_Y64_D0.9210.95
152_L160_K0.9040.94
92_F97_N0.9010.94
2_A6_N0.8990.94
159_A167_Y0.8970.94
124_N151_V0.8810.93
72_S75_S0.8620.93
64_D67_N0.8590.92
160_K165_V0.8580.92
2_A12_G0.8360.91
85_V89_N0.8330.91
48_G51_P0.8300.91
115_A128_A0.8290.91
75_S79_D0.8270.91
120_F130_D0.8270.91
32_Y39_V0.8240.91
154_D157_G0.8180.90
19_D37_N0.8120.90
24_E36_K0.8120.90
61_Y68_V0.8080.90
55_E63_K0.8040.90
65_G70_F0.7930.89
35_D38_N0.7910.89
17_G20_P0.7860.89
84_E93_K0.7720.88
91_Y98_V0.7660.87
71_Y75_S0.7590.87
142_E146_P0.7560.87
54_F57_L0.7530.86
134_V141_L0.7510.86
62_Y69_Y0.7500.86
15_I25_V0.7490.86
127_Y141_L0.7470.86
148_T163_N0.7390.85
90_G101_Y0.7360.85
144_A164_N0.7340.85
82_S87_G0.7310.85
82_S89_N0.7300.85
3_K20_P0.7290.85
4_D9_Y0.7280.85
108_K111_K0.7270.84
117_P120_F0.7180.84
145_D163_N0.7160.84
160_K163_N0.7140.83
158_Y164_N0.7100.83
63_K70_F0.7070.83
129_K149_F0.7040.83
133_N164_N0.7000.82
74_N78_N0.6900.81
130_D133_N0.6890.81
26_L32_Y0.6890.81
128_A149_F0.6880.81
33_A45_K0.6820.81
98_V120_F0.6810.80
51_P56_V0.6780.80
127_Y144_A0.6770.80
107_I111_K0.6750.80
128_A138_G0.6750.80
100_Y128_A0.6750.80
39_V54_F0.6730.80
109_I112_I0.6680.79
22_T26_L0.6680.79
46_L54_F0.6670.79
115_A134_V0.6630.79
62_Y66_K0.6590.78
153_G157_G0.6580.78
123_L126_G0.6580.78
127_Y149_F0.6570.78
59_N62_Y0.6540.78
74_N79_D0.6430.77
81_E86_L0.6420.76
93_K130_D0.6420.76
39_V46_L0.6400.76
53_T65_G0.6370.76
138_G141_L0.6320.75
105_K109_I0.6320.75
103_N139_K0.6310.75
118_K131_K0.6310.75
140_K144_A0.6280.75
91_Y100_Y0.6240.74
53_T64_D0.6170.74
4_D8_V0.6150.73
116_D129_K0.6120.73
98_V102_D0.6120.73
57_L60_N0.6080.72
83_F88_N0.6070.72
118_K147_A0.6060.72
2_A7_N0.6060.72
129_K146_P0.6020.72
8_V25_V0.6010.72
5_K10_Y0.5970.71
157_G163_N0.5970.71
4_D12_G0.5960.71
34_K93_K0.5960.71
91_Y120_F0.5960.71
160_K166_Y0.5940.71
62_Y67_N0.5940.71
50_D54_F0.5920.70
160_K164_N0.5900.70
50_D55_E0.5880.70
102_D109_I0.5880.70
39_V45_K0.5860.70
53_T57_L0.5820.69
18_A35_D0.5820.69
162_K166_Y0.5770.69
50_D57_L0.5760.68
122_V128_A0.5760.68
4_D20_P0.5710.68
127_Y153_G0.5710.68
125_D154_D0.5680.67
1_Y63_K0.5660.67
63_K67_N0.5660.67
127_Y130_D0.5650.67
16_E29_G0.5630.67
71_Y74_N0.5630.67
157_G167_Y0.5590.66
76_L79_D0.5560.66
92_F102_D0.5520.65
93_K98_V0.5480.65
103_N108_K0.5440.64
20_P36_K0.5420.64
143_G157_G0.5420.64
159_A164_N0.5410.64
73_G77_D0.5410.64
116_D130_D0.5400.63
14_K48_G0.5390.63
100_Y104_D0.5380.63
97_N104_D0.5350.63
145_D161_D0.5350.63
40_Y75_S0.5340.63
103_N109_I0.5340.63
119_T129_K0.5340.63
68_V75_S0.5320.62
3_K6_N0.5310.62
146_P149_F0.5300.62
50_D65_G0.5280.62
134_V149_F0.5260.61
10_Y13_K0.5250.61
20_P37_N0.5250.61
80_D83_F0.5250.61
22_T33_A0.5240.61
91_Y127_Y0.5240.61
137_K140_K0.5220.61
119_T134_V0.5190.60
23_F50_D0.5190.60
51_P61_Y0.5170.60
9_Y102_D0.5160.60
72_S77_D0.5130.60
102_D141_L0.5120.59
33_A43_G0.5090.59
123_L128_A0.5080.59
140_K164_N0.5050.58
29_G42_K0.5050.58
39_V49_A0.5040.58
7_N11_K0.5030.58
105_K134_V0.5020.58
85_V88_N0.5020.58
69_Y76_L0.5020.58
152_L157_G0.5000.58
51_P58_G0.5000.58
102_D106_K0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s25A 1 0.7515 3 0.934 Contact Map
4mzvA 2 0.3314 2.7 0.936 Contact Map
2plgA 4 0.2722 2.7 0.936 Contact Map
3bwsA 2 0.3846 2.2 0.938 Contact Map
4gojC 1 0.4734 1.6 0.943 Contact Map
2bklA 1 0.9231 1.5 0.944 Contact Map
1kqrA 1 0.3432 1.4 0.945 Contact Map
3dsmA 1 0.497 1.3 0.945 Contact Map
1mdaH 1 0.4438 1.3 0.945 Contact Map
1pbyB 1 0.4734 1.3 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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