GREMLIN Database
Nucleoporin_FG - Nucleoporin FG repeat region
PFAM: PF13634 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 101 (96)
Sequences: 4673 (4392)
Seq/√Len: 448.3
META: 0.31

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_N86_N2.3981.00
71_T87_T2.2201.00
57_N70_N2.2011.00
28_T71_T2.1301.00
27_N57_N2.0861.00
91_Q94_Q1.8251.00
37_G66_G1.7921.00
24_L38_L1.7421.00
27_N70_N1.7121.00
66_G82_G1.6251.00
57_N86_N1.5711.00
27_N86_N1.5371.00
81_G97_G1.5341.00
72_N88_N1.5051.00
10_G13_L1.5031.00
64_G67_L1.4941.00
28_T58_T1.4901.00
83_L99_L1.4671.00
24_L27_N1.4641.00
58_T71_T1.4601.00
43_S46_T1.4261.00
13_L54_L1.3901.00
58_T87_T1.3841.00
18_T21_G1.3751.00
87_T90_Q1.3711.00
29_T72_N1.3581.00
71_T74_T1.3581.00
36_G65_G1.3231.00
13_L38_L1.3201.00
11_G36_G1.2731.00
34_T63_T1.2711.00
24_L67_L1.2561.00
38_L67_L1.2411.00
11_G22_G1.2401.00
73_T89_N1.2401.00
16_N19_A1.2371.00
13_L67_L1.2271.00
24_L54_L1.2061.00
38_L54_L1.2031.00
65_G81_G1.2001.00
12_G66_G1.1981.00
23_G37_G1.1871.00
17_Q20_T1.1721.00
67_L99_L1.1681.00
21_G35_G1.1501.00
6_Q9_T1.1441.00
19_A33_A1.1191.00
67_L83_L1.1151.00
38_L83_L1.1141.00
64_G80_G1.1091.00
21_G24_L1.1081.00
35_G38_L1.1041.00
13_L83_L1.1031.00
28_T31_T1.0961.00
54_L67_L1.0871.00
72_N75_Q1.0751.00
35_G80_G1.0711.00
80_G96_G1.0491.00
20_T34_T1.0461.00
23_G82_G1.0451.00
18_T32_A1.0211.00
94_Q97_G1.0111.00
27_N30_T0.9651.00
12_G37_G0.9651.00
51_G54_L0.9571.00
12_G23_G0.9571.00
54_L83_L0.9421.00
74_T90_Q0.9341.00
59_T62_T0.9301.00
7_P10_G0.9251.00
35_G64_G0.9191.00
8_A11_G0.9151.00
23_G66_G0.9131.00
47_Q50_T0.9101.00
50_T54_L0.8951.00
30_T73_T0.8911.00
25_F55_F0.8881.00
56_G85_G0.8781.00
75_Q91_Q0.8741.00
28_T87_T0.8631.00
37_G53_G0.8621.00
22_G36_G0.8531.00
14_F39_F0.8421.00
29_T88_N0.8351.00
46_T49_T0.8291.00
31_T74_T0.8241.00
89_N93_Q0.8201.00
53_G66_G0.8181.00
62_T94_Q0.8131.00
37_G82_G0.8091.00
82_G98_G0.8041.00
40_G69_G0.8011.00
96_G99_L0.7901.00
90_Q93_Q0.7891.00
24_L83_L0.7681.00
60_Q63_T0.7661.00
26_G56_G0.7531.00
37_G98_G0.7371.00
22_G25_F0.7341.00
80_G83_L0.7321.00
73_T76_Q0.7301.00
13_L24_L0.7171.00
89_N92_Q0.7091.00
76_Q92_Q0.6981.00
94_Q98_G0.6781.00
66_G98_G0.6761.00
21_G80_G0.6751.00
15_G69_G0.6741.00
15_G56_G0.6741.00
43_S47_Q0.6701.00
22_G65_G0.6561.00
15_G26_G0.6561.00
33_A62_T0.6420.99
69_G85_G0.6370.99
88_N91_Q0.6280.99
44_T47_Q0.6260.99
63_T95_T0.6260.99
76_Q79_T0.6200.99
64_G96_G0.6170.99
40_G101_G0.6120.99
50_T64_G0.6090.99
86_N89_N0.6080.99
16_N45_Q0.5910.99
84_F88_N0.5860.99
61_Q64_G0.5830.99
15_G40_G0.5830.99
26_G40_G0.5820.99
45_Q48_T0.5790.99
54_L99_L0.5770.99
66_G70_N0.5740.99
42_S45_Q0.5700.99
5_Q8_A0.5620.99
53_G82_G0.5600.99
23_G53_G0.5580.99
20_T63_T0.5470.98
72_N76_Q0.5350.98
74_T77_Q0.5300.98
20_T23_G0.5220.98
10_G64_G0.5210.98
19_A22_G0.5150.98
67_L70_N0.5150.98
12_G82_G0.5100.97
90_Q94_Q0.5070.97
36_G81_G0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4x2oC 1 0.0792 2.3 0.872 Contact Map
4l6yA 2 0 0.9 0.9 Contact Map
2bptB 1 0.1089 0.7 0.905 Contact Map
2ebrA 1 0.1584 0.3 0.93 Contact Map
2c55A 1 0.4059 0.3 0.933 Contact Map
3e1kB 1 0.1386 0.3 0.933 Contact Map
3wyfB 1 0.1683 0.3 0.935 Contact Map
3n56C 1 0.0198 0.3 0.936 Contact Map
3wy9C 1 0.1485 0.3 0.936 Contact Map
1q01A 1 0.1584 0.2 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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