GREMLIN Database
Helicase_C_3 - Helicase conserved C-terminal domain
PFAM: PF13625 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 127 (121)
Sequences: 10009 (6199)
Seq/√Len: 563.6
META: 0.856

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_E78_L3.2301.00
32_E42_R3.1221.00
78_L82_R2.8881.00
62_L82_R2.8481.00
62_L78_L2.7051.00
94_G102_R2.6781.00
103_S109_L2.6741.00
30_E44_T2.4131.00
27_R56_L2.3691.00
24_A64_F2.2341.00
75_Q79_Y2.1371.00
9_I43_L2.0761.00
57_T60_E2.0491.00
61_I85_A1.9881.00
63_A67_R1.9571.00
58_A85_A1.9011.00
94_G100_L1.8191.00
56_L60_E1.7701.00
30_E50_R1.7451.00
59_E82_R1.6761.00
7_L80_L1.5911.00
80_L84_W1.5721.00
64_F68_Y1.5291.00
110_A114_A1.4721.00
24_A27_R1.4571.00
21_A68_Y1.4521.00
33_S40_T1.4481.00
111_E115_D1.4461.00
90_R104_D1.4121.00
49_W53_A1.3751.00
28_F61_I1.3531.00
11_L17_L1.3401.00
58_A81_I1.3321.00
24_A56_L1.3031.00
110_A113_L1.3031.00
3_V9_I1.3011.00
106_P110_A1.2961.00
62_L81_I1.2891.00
44_T47_S1.2861.00
52_L85_A1.2781.00
48_L84_W1.2531.00
48_L61_I1.2231.00
79_Y83_D1.2121.00
79_Y82_R1.2021.00
62_L66_E1.1911.00
43_L77_V1.1841.00
63_A66_E1.1761.00
113_L122_L1.1721.00
75_Q78_L1.1581.00
60_E63_A1.1351.00
52_L88_Y1.1201.00
26_A31_L1.1091.00
59_E63_A1.0901.00
103_S112_L1.0811.00
76_N80_L1.0611.00
17_L20_E1.0471.00
48_L85_A1.0331.00
92_R102_R1.0201.00
17_L67_R1.0141.00
31_L39_H1.0001.00
21_A64_F0.9981.00
53_A88_Y0.9921.00
51_A56_L0.9831.00
4_Q10_L0.9771.00
7_L77_V0.9721.00
56_L61_I0.9701.00
7_L76_N0.9661.00
47_S51_A0.9561.00
29_A41_Y0.9501.00
91_L112_L0.9341.00
27_R64_F0.9331.00
69_S73_V0.9331.00
1_L68_Y0.9291.00
48_L52_L0.9281.00
26_A41_Y0.9111.00
80_L83_D0.8931.00
24_A67_R0.8841.00
113_L119_A0.8821.00
17_L68_Y0.8771.00
28_F51_A0.8761.00
118_L123_L0.8671.00
27_R54_A0.8671.00
103_S108_L0.8591.00
43_L65_L0.8581.00
24_A68_Y0.8351.00
91_L103_S0.8281.00
30_E42_R0.8261.00
34_S39_H0.8201.00
73_V78_L0.8171.00
83_D86_R0.8141.00
87_R111_E0.8141.00
12_E70_R0.8091.00
45_P84_W0.7931.00
92_R104_D0.7881.00
56_L64_F0.7821.00
51_A61_I0.7811.00
108_L111_E0.7801.00
28_F43_L0.7751.00
105_D108_L0.7751.00
107_A111_E0.7711.00
10_L40_T0.7671.00
10_L38_A0.7661.00
4_Q8_T0.7641.00
112_L115_D0.7581.00
93_L101_L0.7491.00
8_T32_E0.7451.00
22_R26_A0.7401.00
45_P87_R0.7391.00
18_A21_A0.7321.00
58_A62_L0.7321.00
98_G102_R0.7251.00
76_N79_Y0.7221.00
9_I25_L0.7221.00
30_E46_L0.7211.00
6_D42_R0.7111.00
7_L84_W0.7061.00
59_E62_L0.6971.00
107_A110_A0.6901.00
87_R90_R0.6781.00
111_E114_A0.6761.00
49_W88_Y0.6741.00
22_R39_H0.6741.00
1_L64_F0.6711.00
12_E89_G0.6671.00
118_L122_L0.6651.00
109_L113_L0.6651.00
5_S76_N0.6501.00
12_E38_A0.6491.00
8_T42_R0.6481.00
66_E72_P0.6471.00
90_R105_D0.6461.00
115_D119_A0.6401.00
77_V80_L0.6371.00
3_V73_V0.6351.00
24_A28_F0.6271.00
82_R86_R0.6261.00
25_L64_F0.6181.00
62_L73_V0.6131.00
3_V69_S0.6101.00
9_I21_A0.6041.00
13_V36_E0.6021.00
72_P78_L0.6011.00
28_F56_L0.5991.00
31_L34_S0.5911.00
8_T40_T0.5861.00
52_L58_A0.5821.00
58_A82_R0.5811.00
49_W52_L0.5771.00
19_P23_D0.5751.00
81_I85_A0.5740.99
18_A23_D0.5730.99
115_D118_L0.5720.99
30_E47_S0.5680.99
90_R108_L0.5650.99
1_L9_I0.5650.99
46_L50_R0.5650.99
11_L22_R0.5640.99
28_F64_F0.5640.99
32_E40_T0.5590.99
72_P75_Q0.5570.99
64_F67_R0.5560.99
86_R104_D0.5540.99
117_K120_P0.5520.99
28_F65_L0.5470.99
71_Y74_P0.5390.99
61_I64_F0.5370.99
112_L118_L0.5300.99
57_T61_I0.5300.99
75_Q80_L0.5240.99
88_Y91_L0.5220.99
20_E24_A0.5150.99
50_R54_A0.5150.99
13_V17_L0.5130.99
105_D109_L0.5120.99
13_V37_H0.5070.99
24_A61_I0.5050.99
116_K119_A0.5040.99
107_A114_A0.5040.99
66_E73_V0.5030.99
85_A88_Y0.5030.99
76_N84_W0.5000.99
74_P77_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3domA 1 0.4252 32.9 0.883 Contact Map
2nn6H 1 0.6614 21.3 0.893 Contact Map
3dgpA 1 0.2913 18.4 0.896 Contact Map
3psfA 1 0.8425 16.3 0.898 Contact Map
3psiA 1 0.748 16.2 0.898 Contact Map
3a1yG 1 0.7165 15.1 0.9 Contact Map
4dn7A 2 0.6457 13.6 0.902 Contact Map
3dgpB 1 0.2677 13.6 0.902 Contact Map
4ifdH 1 0.6457 11.4 0.905 Contact Map
3vfdA 1 0.6772 8.1 0.911 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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