GREMLIN Database
Gluconate_2-dh3 - Gluconate 2-dehydrogenase subunit 3
PFAM: PF13618 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 131 (125)
Sequences: 34346 (22562)
Seq/√Len: 2018.0
META: 0.945

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_A25_E3.3341.00
71_S74_Q2.5761.00
48_Y105_L2.3911.00
62_R81_A2.3241.00
8_E24_K2.3091.00
11_A106_T2.2541.00
13_R76_D2.1771.00
3_E49_R1.9881.00
67_F75_Q1.9291.00
27_G30_E1.9151.00
58_E62_R1.9141.00
76_D80_D1.9091.00
9_A75_Q1.8901.00
4_A29_P1.8601.00
13_R75_Q1.8431.00
8_E29_P1.8411.00
46_E50_A1.8061.00
72_P76_D1.8031.00
114_P118_G1.7791.00
63_F74_Q1.6991.00
51_G98_F1.6961.00
31_F109_G1.6731.00
12_D24_K1.6581.00
66_P69_D1.6141.00
74_Q77_A1.5341.00
24_K29_P1.4811.00
4_A33_D1.4691.00
10_L102_L1.4571.00
60_R66_P1.4351.00
3_E53_A1.4051.00
15_I110_Y1.3821.00
65_K74_Q1.3481.00
63_F70_L1.3351.00
11_A29_P1.3141.00
65_K69_D1.2761.00
56_D68_A1.2631.00
13_R79_L1.2621.00
11_A32_I1.2601.00
72_P75_Q1.2501.00
4_A8_E1.2251.00
59_A70_L1.2031.00
58_E78_L1.2021.00
103_R107_L1.2021.00
53_A57_A1.1861.00
6_T68_A1.1771.00
12_D17_A1.1711.00
28_V110_Y1.1621.00
33_D37_A1.1601.00
80_D83_E1.1541.00
111_Y120_R1.1521.00
54_A58_E1.1491.00
6_T10_L1.1221.00
13_R72_P1.1211.00
41_L44_D1.1091.00
56_D66_P1.1011.00
10_L79_L1.1001.00
57_A61_K1.0961.00
59_A78_L1.0931.00
59_A63_F1.0751.00
9_A24_K1.0731.00
45_Q49_R1.0691.00
40_Y43_E1.0661.00
2_E56_D1.0541.00
77_A81_A1.0531.00
34_R38_D1.0261.00
83_E99_F1.0251.00
63_F77_A1.0241.00
9_A13_R1.0231.00
77_A80_D1.0201.00
42_P46_E1.0171.00
58_E61_K0.9941.00
55_L82_L0.9921.00
80_D84_A0.9811.00
9_A68_A0.9761.00
5_A68_A0.9701.00
47_A101_L0.9641.00
2_E66_P0.9621.00
26_A110_Y0.9601.00
87_A90_P0.9551.00
65_K70_L0.9551.00
50_A53_A0.9541.00
54_A57_A0.9451.00
11_A28_V0.9391.00
115_I119_N0.9201.00
12_D25_E0.9111.00
27_G120_R0.9061.00
55_L78_L0.9041.00
105_L108_E0.9031.00
30_E34_R0.8991.00
17_A22_G0.8991.00
6_T56_D0.8991.00
4_A30_E0.8921.00
28_V109_G0.8821.00
2_E68_A0.8801.00
100_N104_D0.8771.00
14_I103_R0.8721.00
31_F108_E0.8651.00
113_S116_G0.8641.00
89_G92_G0.8621.00
6_T52_L0.8521.00
36_L48_Y0.8491.00
7_L102_L0.8481.00
101_L105_L0.8411.00
104_D108_E0.8391.00
5_A69_D0.8211.00
14_I106_T0.8211.00
56_D59_A0.8191.00
111_Y116_G0.8171.00
114_P119_N0.8151.00
123_G126_L0.8111.00
5_A8_E0.8021.00
58_E81_A0.7951.00
54_A95_G0.7941.00
90_P93_S0.7941.00
73_A77_A0.7931.00
22_G25_E0.7841.00
62_R77_A0.7791.00
50_A54_A0.7691.00
44_D101_L0.7401.00
3_E56_D0.7321.00
99_F103_R0.7221.00
48_Y102_L0.7221.00
94_P97_A0.7161.00
2_E6_T0.7161.00
17_A24_K0.7121.00
96_A100_N0.7111.00
26_A122_L0.7011.00
32_I106_T0.6971.00
117_G122_L0.6871.00
15_I107_L0.6841.00
73_A76_D0.6821.00
39_C42_P0.6781.00
70_L74_Q0.6771.00
81_A86_K0.6741.00
2_E5_A0.6641.00
107_L111_Y0.6621.00
47_A97_A0.6601.00
55_L59_A0.6481.00
46_E49_R0.6461.00
17_A20_T0.6421.00
57_A60_R0.6381.00
11_A23_A0.6361.00
122_L125_K0.6311.00
8_E12_D0.6291.00
56_D60_R0.6241.00
29_P33_D0.6211.00
39_C43_E0.6191.00
65_K71_S0.6181.00
44_D47_A0.6131.00
40_Y44_D0.6111.00
88_A92_G0.6101.00
85_G96_A0.6101.00
12_D22_G0.6101.00
10_L55_L0.6021.00
101_L104_D0.6021.00
60_R64_G0.6011.00
35_M38_D0.5941.00
8_E30_E0.5911.00
83_E103_R0.5841.00
114_P117_G0.5811.00
6_T9_A0.5791.00
36_L40_Y0.5781.00
93_S97_A0.5761.00
116_G120_R0.5751.00
32_I109_G0.5731.00
88_A91_E0.5721.00
13_R67_F0.5711.00
117_G120_R0.5681.00
7_L11_A0.5661.00
108_E112_T0.5631.00
110_Y116_G0.5631.00
90_P94_P0.5611.00
116_G119_N0.5591.00
55_L102_L0.5441.00
8_E11_A0.5421.00
81_A85_G0.5421.00
43_E46_E0.5371.00
7_L32_I0.5351.00
35_M108_E0.5321.00
120_R124_W0.5301.00
15_I106_T0.5271.00
51_G55_L0.5271.00
110_Y120_R0.5241.00
76_D79_L0.5231.00
34_R37_A0.5181.00
7_L52_L0.5161.00
42_P45_Q0.5101.00
118_G124_W0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r6nA 1 0.4656 23.8 0.889 Contact Map
2jexA 1 0.4504 21.8 0.891 Contact Map
1tueB 1 0.5038 21 0.891 Contact Map
2nnuA 1 0.4733 17.5 0.895 Contact Map
3plsA 1 0.5115 17 0.896 Contact Map
3zg1A 2 0.6794 16.6 0.896 Contact Map
4rt7A 2 0.4427 8.2 0.91 Contact Map
3vw8A 1 0.4656 7.4 0.911 Contact Map
4ksaA 3 0.916 7.4 0.911 Contact Map
4ksfA 3 0.8626 7.3 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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