GREMLIN Database
DUF4141 - Domain of unknown function (DUF4141)
PFAM: PF13605 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 53 (52)
Sequences: 793 (484)
Seq/√Len: 67.1
META: 0.868

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_A49_M2.8321.00
28_L31_S2.7361.00
35_T38_E2.6271.00
49_M52_N2.3121.00
21_V25_P2.2911.00
31_S34_N1.9801.00
23_T28_L1.8841.00
20_W26_A1.7981.00
47_S51_K1.7611.00
23_T26_A1.4220.98
14_G17_K1.4210.98
8_A11_L1.4000.98
46_A51_K1.3010.97
7_L10_L1.2520.96
30_Q33_V1.2470.96
36_A41_Q1.2240.95
35_T39_I1.2030.95
45_T48_N1.1600.94
6_A12_F1.1550.94
42_T45_T1.1440.93
48_N51_K1.1330.93
44_S50_I1.1320.93
7_L12_F1.1220.93
6_A10_L1.1000.92
38_E41_Q1.0920.92
4_I15_Q1.0450.90
12_F15_Q1.0430.90
5_L15_Q1.0110.88
22_V27_N1.0050.88
40_V43_S0.9970.87
8_A12_F0.9930.87
34_N42_T0.9760.86
4_I14_G0.9660.86
41_Q44_S0.8860.80
2_I7_L0.8820.80
4_I11_L0.8790.80
20_W30_Q0.8760.80
4_I7_L0.8540.78
5_L8_A0.8340.76
36_A40_V0.8330.76
45_T49_M0.8250.76
10_L14_G0.8220.75
3_I14_G0.8030.74
34_N38_E0.7940.73
3_I6_A0.7880.72
27_N31_S0.7560.69
31_S36_A0.7320.67
21_V27_N0.7290.66
4_I10_L0.7270.66
3_I10_L0.7090.64
29_A53_F0.7070.64
29_A33_V0.7030.63
40_V47_S0.6950.62
22_V37_N0.6830.61
8_A15_Q0.6510.57
31_S35_T0.6460.57
10_L15_Q0.6450.57
5_L53_F0.6450.57
38_E42_T0.6400.56
11_L14_G0.6320.55
3_I16_A0.6220.54
29_A37_N0.5990.51
44_S49_M0.5970.51
30_Q38_E0.5890.50
47_S50_I0.5810.49
30_Q37_N0.5710.48
4_I8_A0.5650.47
31_S42_T0.5610.47
12_F17_K0.5450.45
25_P40_V0.5360.44
9_L13_T0.5180.42
3_I13_T0.5170.42
21_V26_A0.5160.42
29_A32_I0.5160.42
4_I12_F0.5130.41
44_S48_N0.5080.41
22_V30_Q0.5070.41
11_L15_Q0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r8iA 1 0.4528 67.4 0.781 Contact Map
1dbgA 1 0.5472 37.9 0.816 Contact Map
4o5jA 1 0.9811 6.5 0.872 Contact Map
2xfcB 3 0 2.8 0.892 Contact Map
2yewC 3 0.3396 2.8 0.893 Contact Map
4fczB 1 0.6226 2.8 0.893 Contact Map
3j0cB 3 0.3396 2.8 0.893 Contact Map
3j0fI 3 0.3396 2.7 0.893 Contact Map
4bgoA 1 0.6038 2.7 0.894 Contact Map
4pnbA 3 0.5283 2.6 0.894 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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