GREMLIN Database
DUF4140 - N-terminal domain of unknown function (DUF4140)
PFAM: PF13600 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 100 (98)
Sequences: 11589 (9046)
Seq/√Len: 913.8
META: 0.908

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_E75_E2.6781.00
20_P24_N2.6481.00
44_G48_V2.4601.00
75_E78_A2.4421.00
15_A28_F2.3931.00
83_L87_Q2.3671.00
78_A82_E2.2681.00
86_L89_E2.1851.00
74_D78_A2.1061.00
91_A94_E2.0751.00
82_E85_A2.0391.00
76_I80_E1.9061.00
72_L76_I1.8881.00
90_I94_E1.7931.00
37_P55_V1.7331.00
84_A88_D1.6781.00
42_V53_V1.6211.00
1_A12_T1.5061.00
93_L96_E1.4841.00
94_E98_A1.4721.00
67_E71_E1.4521.00
87_Q91_A1.4051.00
70_K74_D1.3951.00
80_E84_A1.3911.00
79_L83_L1.3881.00
19_L24_N1.3831.00
88_D91_A1.3621.00
80_E83_L1.3601.00
5_Y10_Q1.3571.00
88_D92_A1.3501.00
66_E71_E1.3351.00
85_A89_E1.3301.00
31_L35_L1.3121.00
77_E81_D1.3011.00
92_A95_A1.3001.00
71_E74_D1.2791.00
73_E77_E1.2641.00
95_A98_A1.2581.00
87_Q90_I1.2541.00
79_L82_E1.1951.00
78_A81_D1.1941.00
2_V11_V1.1871.00
84_A87_Q1.1791.00
81_D85_A1.1641.00
40_L55_V1.1461.00
65_D73_E1.1371.00
81_D84_A1.1291.00
23_T51_L1.0701.00
93_L97_L1.0651.00
35_L40_L1.0601.00
73_E76_I1.0381.00
94_E97_L1.0361.00
44_G50_I1.0191.00
65_D68_E1.0181.00
91_A95_A1.0161.00
37_P57_R1.0121.00
35_L55_V1.0121.00
77_E80_E0.9891.00
40_L53_V0.9841.00
83_L86_L0.9751.00
89_E93_L0.9731.00
74_D77_E0.9681.00
75_E79_L0.9551.00
60_L64_P0.9391.00
96_E99_F0.9341.00
21_A24_N0.9281.00
90_I93_L0.9151.00
85_A88_D0.8981.00
76_I83_L0.8961.00
70_K73_E0.8921.00
92_A97_L0.8721.00
19_L26_L0.8711.00
8_G36_D0.8701.00
61_E64_P0.8381.00
68_E71_E0.8171.00
52_S58_N0.8151.00
72_L75_E0.8011.00
45_E48_V0.8001.00
92_A96_E0.7961.00
82_E86_L0.7801.00
3_T10_Q0.7731.00
65_D70_K0.7731.00
17_V24_N0.7651.00
15_A18_D0.7501.00
62_E65_D0.7481.00
1_A10_Q0.7271.00
51_L55_V0.7201.00
53_V56_R0.7201.00
27_V56_R0.7121.00
75_E82_E0.7081.00
86_L90_I0.6941.00
62_E66_E0.6801.00
17_V26_L0.6791.00
13_R28_F0.6741.00
88_D93_L0.6711.00
50_I54_R0.6691.00
19_L48_V0.6681.00
16_T19_L0.6581.00
66_E70_K0.6491.00
83_L90_I0.6461.00
88_D95_A0.6451.00
86_L93_L0.6381.00
73_E85_A0.6331.00
63_A73_E0.6271.00
76_I79_L0.6241.00
80_E87_Q0.6231.00
27_V30_G0.6201.00
60_L63_A0.6201.00
52_S56_R0.6161.00
82_E89_E0.6081.00
31_L42_V0.6061.00
32_P35_L0.6011.00
52_S55_V0.6001.00
74_D81_D0.5981.00
35_L42_V0.5961.00
89_E92_A0.5941.00
87_Q94_E0.5901.00
28_F31_L0.5801.00
18_D24_N0.5771.00
63_A67_E0.5751.00
93_L99_F0.5741.00
2_V9_A0.5661.00
32_P41_R0.5591.00
15_A19_L0.5521.00
79_L86_L0.5521.00
64_P67_E0.5511.00
87_Q93_L0.5511.00
42_V51_L0.5491.00
4_V13_R0.5481.00
15_A25_E0.5471.00
41_R55_V0.5391.00
63_A66_E0.5331.00
2_V6_P0.5301.00
67_E70_K0.5291.00
64_P68_E0.5291.00
48_V51_L0.5251.00
4_V10_Q0.5231.00
33_P57_R0.5211.00
63_A68_E0.5181.00
44_G49_T0.5131.00
91_A97_L0.5091.00
9_A18_D0.5091.00
8_G42_V0.5071.00
1_A67_E0.5041.00
56_R60_L0.5031.00
37_P54_R0.5011.00
31_L40_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kmqA 1 0.44 26.8 0.844 Contact Map
3zm8A 1 0.94 22.6 0.849 Contact Map
4etpA 1 0.32 17.6 0.857 Contact Map
2vzsA 1 0 16 0.859 Contact Map
1w9sA 1 0.44 13.4 0.864 Contact Map
2vzpA 1 0.42 13 0.864 Contact Map
3hrzB 1 0.5 12.9 0.865 Contact Map
2w47A 1 0.5 12.8 0.865 Contact Map
2oqqA 3 0.36 12.4 0.866 Contact Map
3c9iA 5 0.93 11.8 0.867 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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