GREMLIN Database
DUF4134 - Domain of unknown function (DUF4134)
PFAM: PF13572 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 93 (91)
Sequences: 1650 (768)
Seq/√Len: 80.5
META: 0.849

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_T32_R4.8861.00
21_N37_P3.8621.00
26_E30_M3.1121.00
60_K67_D2.8531.00
46_G82_L2.7711.00
65_D70_K2.5691.00
62_N78_S2.4291.00
7_L10_A2.0171.00
49_V59_Q1.9151.00
12_L15_F1.9141.00
41_L45_I1.8751.00
60_K71_V1.6931.00
60_K65_D1.6871.00
25_N37_P1.5871.00
24_I41_L1.5761.00
58_Y62_N1.5150.99
63_S66_P1.4950.99
21_N33_S1.3650.99
61_W68_T1.3640.99
3_L7_L1.3600.99
4_L12_L1.3260.98
5_L15_F1.3040.98
26_E29_T1.3040.98
20_G34_Y1.2930.98
57_V68_T1.2530.98
68_T72_A1.2450.98
8_L14_A1.2020.97
42_M51_L1.1870.97
6_L10_A1.1510.96
81_F85_V1.1500.96
40_N44_A1.1410.96
5_L8_L1.1280.96
68_T71_V1.0970.95
4_L7_L1.0940.95
18_D30_M1.0920.95
7_L11_A1.0820.95
86_A89_L1.0710.94
43_Y87_T1.0640.94
79_C83_V1.0550.94
25_N40_N1.0540.94
36_D90_K1.0470.94
10_A13_S1.0300.93
25_N33_S1.0110.92
62_N70_K0.9880.91
5_L12_L0.9680.91
42_M54_A0.9680.91
83_V92_F0.9670.91
59_Q73_A0.9620.90
46_G79_C0.9540.90
23_G27_A0.9370.89
39_T86_A0.9290.89
29_T32_R0.9270.89
6_L13_S0.9240.88
9_L14_A0.9230.88
6_L15_F0.9170.88
61_W74_A0.9120.88
45_I49_V0.9110.88
10_A15_F0.9080.88
25_N36_D0.8980.87
45_I52_I0.8870.86
56_K71_V0.8820.86
84_V87_T0.8750.86
87_T91_S0.8730.85
67_D70_K0.8640.85
4_L10_A0.8620.85
37_P48_V0.8490.84
9_L13_S0.8400.83
41_L47_A0.8320.83
30_M42_M0.8300.82
65_D71_V0.8120.81
35_F73_A0.8080.81
5_L10_A0.8070.81
53_G75_W0.7780.78
79_C89_L0.7730.78
3_L11_A0.7560.76
4_L13_S0.7550.76
25_N28_T0.7540.76
57_V72_A0.7510.76
7_L12_L0.7450.75
69_G73_A0.7350.74
60_K70_K0.7340.74
67_D71_V0.7220.73
28_T40_N0.7160.72
68_T74_A0.7150.72
6_L9_L0.7150.72
21_N25_N0.7060.71
36_D40_N0.7040.71
3_L10_A0.6990.70
39_T90_K0.6880.69
22_A56_K0.6820.68
59_Q62_N0.6770.68
51_L69_G0.6720.67
79_C86_A0.6710.67
35_F38_G0.6620.66
43_Y86_A0.6610.66
20_G23_G0.6510.65
19_G40_N0.6430.64
49_V82_L0.6420.64
8_L13_S0.6380.63
39_T43_Y0.6330.63
7_L14_A0.6270.62
73_A76_F0.6230.61
63_S70_K0.6130.60
4_L8_L0.6130.60
18_D22_A0.5950.58
9_L12_L0.5940.58
6_L12_L0.5890.57
54_A85_V0.5860.57
79_C92_F0.5850.57
21_N36_D0.5840.57
18_D21_N0.5790.56
3_L6_L0.5760.55
33_S44_A0.5730.55
58_Y64_G0.5730.55
6_L11_A0.5620.54
50_G69_G0.5610.54
8_L12_L0.5580.53
29_T40_N0.5580.53
46_G50_G0.5570.53
29_T33_S0.5530.53
7_L13_S0.5520.52
80_I84_V0.5510.52
84_V89_L0.5440.51
7_L15_F0.5400.51
5_L13_S0.5360.50
27_A31_V0.5350.50
24_I27_A0.5330.50
78_S85_V0.5320.50
58_Y78_S0.5260.49
25_N29_T0.5220.48
28_T44_A0.5140.47
79_C82_L0.5130.47
20_G79_C0.5100.47
53_G67_D0.5100.47
19_G33_S0.5040.46
27_A53_G0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wswA 3 0.9677 16.6 0.882 Contact Map
4k1cA 4 0.8495 13 0.888 Contact Map
4c7rA 3 0.9677 12.2 0.889 Contact Map
3bz1X 1 0.3978 9.6 0.895 Contact Map
2zy9A 2 0.9032 7.5 0.899 Contact Map
2yevB 1 0.8065 6.6 0.902 Contact Map
3j01A 1 0.3871 5.7 0.905 Contact Map
4lz6A 1 0.9462 5.6 0.905 Contact Map
4humA 1 0.9785 5.6 0.905 Contact Map
3mktA 1 0.9462 5.2 0.907 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0048 seconds.