GREMLIN Database
DUF4132 - Domain of unknown function (DUF4132)
PFAM: PF13569 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 179 (178)
Sequences: 4733 (3912)
Seq/√Len: 293.2
META: 0.804

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_H131_Y3.3841.00
149_D152_R3.2571.00
55_R60_D3.1301.00
94_D98_E3.0191.00
117_D120_E2.9601.00
48_R109_R2.9541.00
151_E159_R2.8951.00
74_G109_R2.6781.00
50_P53_E2.5811.00
58_L68_A2.5311.00
48_R107_R2.5131.00
35_Q64_V2.4081.00
97_G131_Y2.3591.00
65_G69_R2.2441.00
72_V140_L2.2231.00
103_P106_A2.1671.00
166_R169_Q2.1651.00
46_G115_D2.0381.00
65_G90_G1.9781.00
148_T151_E1.9691.00
76_Y109_R1.8831.00
158_N161_A1.8661.00
138_K143_E1.8331.00
51_A102_L1.8051.00
171_R175_K1.7741.00
42_A49_W1.7561.00
35_Q38_R1.7471.00
51_A55_R1.7331.00
125_R141_F1.6791.00
88_E91_S1.6711.00
126_E130_D1.6291.00
52_A56_E1.6011.00
121_V125_R1.5971.00
154_T158_N1.5831.00
74_G115_D1.5481.00
74_G82_L1.5421.00
111_A116_L1.5301.00
147_L152_R1.5141.00
72_V128_L1.5041.00
128_L133_I1.4851.00
43_M110_L1.4321.00
10_P18_A1.4021.00
22_K25_K1.3911.00
11_V18_A1.3711.00
56_E60_D1.3461.00
82_L86_F1.3211.00
52_A104_D1.3191.00
53_E57_R1.3131.00
40_E142_R1.2961.00
84_G87_R1.2951.00
14_D18_A1.2821.00
15_D18_A1.2571.00
9_A12_K1.2491.00
76_Y82_L1.2451.00
129_A141_F1.2451.00
71_L110_L1.2421.00
48_R76_Y1.2351.00
49_W54_W1.2331.00
53_E56_E1.2291.00
9_A13_K1.2221.00
27_E30_A1.2111.00
41_R45_T1.1781.00
118_A122_A1.1751.00
128_L140_L1.1741.00
30_A33_S1.1731.00
97_G130_D1.1721.00
55_R59_L1.1661.00
40_E137_F1.1631.00
95_A123_A1.1621.00
74_G111_A1.1471.00
95_A120_E1.1461.00
27_E31_V1.1451.00
170_L174_L1.1351.00
19_K22_K1.1321.00
116_L120_E1.1291.00
49_W53_E1.1201.00
169_Q173_L1.1091.00
118_A121_V1.1011.00
75_F108_V1.0971.00
10_P14_D1.0861.00
93_V131_Y1.0821.00
93_V127_H1.0771.00
82_L85_T1.0631.00
59_L92_L1.0621.00
109_R115_D1.0601.00
23_A27_E1.0551.00
169_Q172_A1.0531.00
42_A58_L1.0531.00
50_P107_R1.0351.00
72_V124_W1.0321.00
148_T159_R1.0301.00
26_K30_A1.0301.00
54_W73_W1.0281.00
25_K29_K1.0231.00
167_Q171_R1.0181.00
171_R176_K1.0161.00
74_G116_L0.9991.00
55_R92_L0.9981.00
93_V97_G0.9941.00
46_G109_R0.9881.00
127_H133_I0.9701.00
94_D100_V0.9641.00
151_E154_T0.9611.00
83_L86_F0.9581.00
55_R104_D0.9571.00
59_L68_A0.9381.00
112_H142_R0.9251.00
29_K33_S0.9201.00
97_G127_H0.9121.00
138_K141_F0.9101.00
168_H171_R0.9081.00
32_L36_R0.9051.00
89_D131_Y0.9001.00
77_D80_K0.8971.00
75_F105_D0.8921.00
20_E24_L0.8721.00
120_E123_A0.8631.00
88_E93_V0.8561.00
87_R127_H0.8551.00
173_L177_R0.8521.00
38_R47_R0.8511.00
37_A40_E0.8501.00
77_D105_D0.8411.00
72_V111_A0.8361.00
165_L170_L0.8361.00
158_N162_G0.8221.00
91_S99_P0.8161.00
73_W110_L0.8111.00
24_L28_L0.8081.00
70_R133_I0.8071.00
172_A176_K0.8051.00
85_T124_W0.8021.00
22_K26_K0.7990.99
52_A105_D0.7980.99
151_E157_S0.7970.99
113_P121_V0.7900.99
75_F100_V0.7870.99
39_L42_A0.7830.99
171_R174_L0.7830.99
126_E129_A0.7770.99
54_W108_V0.7730.99
79_G82_L0.7710.99
68_A73_W0.7680.99
75_F106_A0.7630.99
7_L10_P0.7580.99
135_Q138_K0.7580.99
33_S37_A0.7560.99
149_D153_E0.7520.99
122_A126_E0.7510.99
152_R157_S0.7490.99
119_E122_A0.7460.99
39_L64_V0.7410.99
113_P142_R0.7320.99
76_Y79_G0.7290.99
75_F86_F0.7180.99
7_L18_A0.7170.99
168_H173_L0.7150.99
148_T153_E0.7130.99
14_D17_E0.7100.99
39_L58_L0.7060.99
114_L144_V0.7010.99
148_T154_T0.7000.99
4_L7_L0.6970.99
30_A34_A0.6900.98
142_R179_W0.6880.98
87_R131_Y0.6850.98
11_V14_D0.6850.98
31_V34_A0.6840.98
88_E130_D0.6810.98
168_H172_A0.6810.98
116_L140_L0.6810.98
38_R61_H0.6790.98
150_A154_T0.6770.98
135_Q143_E0.6760.98
145_Y151_E0.6710.98
156_Y161_A0.6700.98
167_Q170_L0.6620.98
88_E131_Y0.6620.98
70_R136_P0.6610.98
163_H169_Q0.6600.98
111_A140_L0.6570.98
39_L67_L0.6570.98
58_L64_V0.6560.98
165_L173_L0.6560.98
157_S163_H0.6540.98
12_K15_D0.6510.98
97_G132_E0.6500.98
83_L87_R0.6490.98
169_Q175_K0.6430.98
159_R163_H0.6420.98
19_K23_A0.6400.98
80_K83_L0.6350.97
118_A146_L0.6350.97
168_H174_L0.6340.97
164_I167_Q0.6340.97
163_H177_R0.6310.97
57_R64_V0.6300.97
21_L25_K0.6280.97
6_S9_A0.6270.97
91_S130_D0.6260.97
84_G100_V0.6230.97
167_Q174_L0.6210.97
38_R49_W0.6190.97
35_Q42_A0.6190.97
89_D130_D0.6130.97
95_A131_Y0.6080.97
113_P138_K0.6030.97
127_H130_D0.6020.96
11_V15_D0.6000.96
101_E105_D0.5930.96
148_T152_R0.5920.96
157_S160_F0.5910.96
89_D97_G0.5910.96
166_R170_L0.5830.96
167_Q172_A0.5810.96
172_A175_K0.5810.96
93_V99_P0.5760.95
2_K6_S0.5710.95
87_R97_G0.5700.95
37_A41_R0.5690.95
35_Q67_L0.5690.95
41_R47_R0.5680.95
12_K16_A0.5680.95
79_G105_D0.5670.95
43_M137_F0.5670.95
35_Q49_W0.5670.95
75_F84_G0.5640.95
59_L65_G0.5630.95
157_S161_A0.5610.95
119_E123_A0.5590.95
76_Y107_R0.5590.95
51_A104_D0.5560.95
110_L116_L0.5560.95
145_Y160_F0.5560.95
100_V103_P0.5540.94
40_E136_P0.5530.94
41_R44_L0.5510.94
142_R145_Y0.5440.94
85_T120_E0.5420.94
61_H65_G0.5370.93
42_A45_T0.5360.93
49_W63_L0.5350.93
168_H176_K0.5340.93
75_F103_P0.5340.93
4_L10_P0.5280.93
76_Y80_K0.5280.93
116_L121_V0.5250.93
160_F163_H0.5250.93
173_L176_K0.5240.93
163_H173_L0.5210.92
86_F92_L0.5190.92
138_K148_T0.5180.92
13_K18_A0.5180.92
93_V100_V0.5170.92
166_R173_L0.5160.92
166_R176_K0.5160.92
141_F145_Y0.5150.92
63_L70_R0.5140.92
63_L66_P0.5130.92
72_V95_A0.5120.92
34_A37_A0.5110.92
91_S98_E0.5100.92
29_K32_L0.5090.92
125_R129_A0.5080.91
54_W92_L0.5080.91
157_S179_W0.5010.91
4_L11_V0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cr8A 4 0.8045 11.6 0.94 Contact Map
3cuqB 1 0.4246 5.8 0.947 Contact Map
4c26A 1 0.1229 4.5 0.95 Contact Map
4gehA 1 0.4804 4.4 0.951 Contact Map
2wdcA 1 0.9218 4.1 0.951 Contact Map
4onqA 1 0.3799 3.7 0.952 Contact Map
1xmbA 1 0.2682 3.7 0.952 Contact Map
3k6tA 2 0.3017 3.5 0.953 Contact Map
1n08A 1 0.3017 3.4 0.953 Contact Map
4dq1A 2 0.8603 3.3 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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