GREMLIN Database
DUF4131 - Domain of unknown function (DUF4131)
PFAM: PF13567 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 176 (168)
Sequences: 40700 (35524)
Seq/√Len: 2740.7
META: 0.882

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_G168_G4.1131.00
82_G99_L3.7531.00
153_F158_Y3.0511.00
85_V100_R2.9991.00
155_Y159_L2.9071.00
81_E136_R2.7051.00
130_R133_D2.6781.00
146_G156_R2.3331.00
79_T136_R2.2101.00
86_E98_V2.2011.00
79_T138_T2.1791.00
83_V134_R2.1781.00
81_E134_R2.1481.00
55_G59_R2.1201.00
102_E134_R2.0841.00
144_P159_L1.9691.00
52_G55_G1.9631.00
81_E103_S1.9621.00
157_R161_R1.9501.00
98_V116_R1.9451.00
85_V116_R1.9421.00
82_G137_L1.9101.00
160_A165_Y1.7591.00
57_A61_A1.7501.00
53_F56_A1.7461.00
105_L110_W1.6961.00
158_Y162_Q1.6711.00
144_P167_T1.6121.00
4_I7_A1.5921.00
83_V102_E1.5751.00
98_V164_I1.5411.00
146_G154_D1.5191.00
100_R116_R1.5021.00
67_D70_R1.5001.00
58_L62_R1.4871.00
80_V139_G1.4671.00
154_D157_R1.4501.00
147_P152_G1.4201.00
103_S110_W1.3971.00
87_L131_Y1.3781.00
54_L57_A1.3651.00
97_F121_V1.3601.00
149_N152_G1.3281.00
55_G58_L1.3161.00
56_A59_R1.3111.00
98_V118_R1.2941.00
143_P156_R1.2881.00
61_A64_L1.2761.00
8_F11_A1.2761.00
68_L71_L1.2681.00
57_A60_A1.2551.00
9_L12_L1.2501.00
96_R118_R1.2481.00
94_G120_S1.2331.00
99_L135_V1.2241.00
82_G135_V1.2061.00
66_D69_P1.1971.00
83_V100_R1.1941.00
85_V98_V1.1841.00
49_L52_G1.1811.00
69_P73_E1.1801.00
84_V129_L1.1791.00
59_R62_R1.1711.00
156_R160_A1.1651.00
70_R73_E1.1641.00
142_R169_Y1.1281.00
56_A60_A1.1221.00
90_R95_T1.0901.00
117_V141_L1.0781.00
91_R94_G1.0771.00
64_L67_D1.0701.00
145_R148_R1.0671.00
58_L61_A1.0651.00
59_R63_R1.0641.00
117_V166_A1.0581.00
68_L72_L1.0571.00
91_R96_R1.0541.00
68_L73_E1.0521.00
77_P138_T1.0521.00
148_R152_G1.0481.00
77_P140_R1.0461.00
53_F57_A1.0351.00
145_R156_R1.0321.00
67_D71_L1.0151.00
65_A68_L1.0061.00
45_L48_L1.0001.00
88_P91_R0.9971.00
60_A63_R0.9961.00
106_D109_R0.9931.00
54_L58_L0.9841.00
81_E102_E0.9761.00
85_V88_P0.9751.00
8_F12_L0.9691.00
141_L168_G0.9671.00
112_P115_G0.9661.00
96_R120_S0.9641.00
10_P13_P0.9581.00
99_L119_L0.9581.00
157_R160_A0.9511.00
137_L168_G0.9461.00
12_L16_L0.9441.00
61_A65_A0.9381.00
159_L164_I0.9381.00
137_L170_V0.9311.00
147_P154_D0.9301.00
60_A64_L0.9271.00
51_L54_L0.9251.00
52_G56_A0.9221.00
42_L45_L0.9191.00
147_P156_R0.9191.00
69_P72_L0.9141.00
98_V162_Q0.9131.00
101_V117_V0.9041.00
121_V124_D0.9031.00
89_E96_R0.9021.00
26_L30_L0.8971.00
155_Y167_T0.8951.00
43_L46_L0.8801.00
143_P166_A0.8721.00
159_L167_T0.8651.00
121_V129_L0.8601.00
14_P17_W0.8541.00
47_L50_L0.8511.00
8_F13_P0.8511.00
41_L44_L0.8471.00
144_P156_R0.8451.00
108_G111_R0.8331.00
48_L51_L0.8271.00
36_R39_R0.8231.00
12_L15_P0.8201.00
44_L48_L0.8161.00
119_L168_G0.8111.00
81_E85_V0.8081.00
62_R65_A0.8071.00
115_G119_L0.7961.00
37_R41_L0.7951.00
86_E131_Y0.7911.00
141_L166_A0.7791.00
46_L49_L0.7751.00
142_R167_T0.7741.00
29_L32_L0.7721.00
99_L137_L0.7711.00
114_P165_Y0.7611.00
161_R165_Y0.7591.00
38_R41_L0.7581.00
134_R138_T0.7491.00
80_V137_L0.7431.00
50_L53_F0.7391.00
44_L55_G0.7381.00
63_R66_D0.7341.00
155_Y158_Y0.7241.00
84_V97_F0.7211.00
99_L117_V0.7181.00
144_P166_A0.7101.00
129_L133_D0.7091.00
51_L55_G0.7061.00
36_R40_R0.6961.00
16_L19_L0.6951.00
13_P17_W0.6931.00
88_P95_T0.6931.00
42_L46_L0.6831.00
19_L22_L0.6831.00
72_L166_A0.6831.00
55_G61_A0.6781.00
28_L32_L0.6761.00
9_L15_P0.6721.00
11_A15_P0.6721.00
44_L47_L0.6651.00
49_L53_F0.6651.00
88_P97_F0.6651.00
27_L31_L0.6651.00
122_Y169_Y0.6641.00
105_L109_R0.6581.00
105_L108_G0.6571.00
120_S167_T0.6571.00
80_V141_L0.6541.00
43_L47_L0.6531.00
41_L45_L0.6511.00
131_Y134_R0.6511.00
80_V101_V0.6491.00
40_R44_L0.6481.00
39_R42_L0.6481.00
77_P81_E0.6381.00
115_G118_R0.6361.00
86_E97_F0.6331.00
9_L14_P0.6301.00
50_L54_L0.6271.00
45_L49_L0.6261.00
90_R93_D0.6231.00
15_P19_L0.6201.00
119_L137_L0.6191.00
158_Y161_R0.6171.00
10_P14_P0.6161.00
19_L23_L0.6151.00
118_R155_Y0.6151.00
115_G122_Y0.6151.00
23_L27_L0.6131.00
118_R122_Y0.6091.00
129_L135_V0.6091.00
17_W20_A0.6061.00
29_L33_R0.6061.00
20_A23_L0.6041.00
37_R40_R0.6011.00
10_P15_P0.5991.00
14_P18_L0.5981.00
83_V87_L0.5971.00
48_L52_G0.5971.00
64_L70_R0.5921.00
120_S169_Y0.5891.00
25_L28_L0.5881.00
30_L33_R0.5871.00
78_V82_G0.5841.00
92_E95_T0.5821.00
67_D73_E0.5811.00
63_R67_D0.5771.00
46_L57_A0.5771.00
116_R120_S0.5761.00
11_A17_W0.5731.00
43_L50_L0.5691.00
110_W113_V0.5661.00
62_R66_D0.5661.00
121_V170_V0.5641.00
27_L30_L0.5621.00
119_L139_G0.5551.00
95_T129_L0.5531.00
82_G102_E0.5521.00
124_D127_P0.5491.00
11_A14_P0.5471.00
147_P151_G0.5431.00
2_A5_L0.5421.00
25_L29_L0.5381.00
95_T123_G0.5381.00
81_E110_W0.5371.00
104_V113_V0.5361.00
52_G57_A0.5351.00
97_F129_L0.5341.00
12_L17_W0.5321.00
118_R159_L0.5311.00
54_L59_R0.5271.00
80_V168_G0.5261.00
53_F60_A0.5251.00
97_F101_V0.5241.00
90_R94_G0.5211.00
75_G78_V0.5171.00
66_D71_L0.5171.00
90_R123_G0.5161.00
55_G60_A0.5131.00
17_W21_A0.5081.00
77_P171_R0.5031.00
40_R43_L0.5011.00
42_L52_G0.5011.00
24_A28_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1n9wA 2 0.483 32.1 0.875 Contact Map
3ja87 1 0.8239 25.1 0.881 Contact Map
3nemA 2 0.5057 23.2 0.883 Contact Map
4gn4B 1 0.5398 22.6 0.884 Contact Map
1l0wA 2 0.5341 22.6 0.884 Contact Map
1wydA 2 0.5057 21.7 0.885 Contact Map
3f2bA 1 0.5682 21.1 0.886 Contact Map
1c0aA 1 0.5398 19.3 0.888 Contact Map
4me3A 1 0.7386 18.9 0.888 Contact Map
2jwaA 2 0.1761 17.9 0.889 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0068 seconds.