GREMLIN Database
DUF4130 - Domain of unknown function (DUF4130
PFAM: PF13566 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 146 (145)
Sequences: 6089 (4064)
Seq/√Len: 337.5
META: 0.828

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_K75_L3.2151.00
133_R138_K3.1721.00
9_R29_D2.9691.00
70_N97_L2.8871.00
44_A48_K2.7051.00
76_A99_L2.4831.00
118_Y132_Q2.4801.00
13_R27_D2.4241.00
54_R111_E2.3281.00
62_V91_Y2.3091.00
66_E142_K2.2661.00
66_E143_N2.1581.00
31_L35_K2.1501.00
66_E93_P2.0101.00
136_M141_W1.9851.00
131_L134_Q1.9551.00
122_F127_L1.9501.00
68_D139_R1.9161.00
64_W93_P1.9031.00
131_L135_E1.8851.00
55_E61_Y1.8331.00
138_K141_W1.8121.00
44_A74_L1.8061.00
51_V65_I1.7981.00
61_Y86_M1.7961.00
129_P133_R1.7271.00
10_Y33_L1.6871.00
130_K133_R1.6231.00
10_Y22_L1.6081.00
6_L32_R1.5841.00
45_H48_K1.5011.00
37_A41_R1.4951.00
44_A75_L1.4851.00
124_P127_L1.4601.00
112_E115_K1.4461.00
45_H49_A1.3891.00
51_V63_A1.3461.00
32_R35_K1.3461.00
32_R36_L1.3421.00
116_T120_S1.2551.00
5_A9_R1.2331.00
39_K68_D1.2311.00
20_R23_E1.2241.00
40_V69_H1.2221.00
43_E71_I1.2171.00
92_D95_R1.1971.00
128_N131_L1.1891.00
47_M71_I1.1881.00
33_L37_A1.1871.00
93_P143_N1.1721.00
43_E139_R1.1641.00
39_K69_H1.1591.00
132_Q141_W1.1501.00
8_Y12_W1.1411.00
130_K134_Q1.1391.00
55_E59_G1.1351.00
87_R102_D1.1221.00
50_F144_L1.1041.00
89_S100_H1.0861.00
98_A101_Y1.0851.00
70_N95_R1.0851.00
18_G21_L1.0811.00
51_V90_I1.0801.00
106_D109_A1.0511.00
11_L15_L1.0421.00
89_S98_A1.0301.00
54_R64_W1.0291.00
107_E111_E1.0261.00
66_E94_K1.0191.00
6_L33_L1.0161.00
55_E104_A1.0011.00
9_R12_W0.9961.00
95_R101_Y0.9931.00
96_K99_L0.9921.00
2_E32_R0.9921.00
95_R98_A0.9891.00
132_Q136_M0.9821.00
34_L37_A0.9791.00
56_V60_V0.9771.00
13_R29_D0.9741.00
63_A90_I0.9731.00
140_Y143_N0.9661.00
12_W16_R0.9611.00
79_F90_I0.9471.00
111_E145_P0.9451.00
14_G21_L0.9391.00
46_K49_A0.9351.00
46_K135_E0.9341.00
121_I128_N0.9291.00
14_G17_G0.9291.00
110_Y113_L0.9281.00
47_M65_I0.9221.00
64_W143_N0.9131.00
46_K140_Y0.9101.00
116_T119_K0.8891.00
46_K50_F0.8841.00
48_K78_H0.8841.00
42_R49_A0.8761.00
7_L33_L0.8711.00
47_M75_L0.8631.00
42_R46_K0.8541.00
10_Y30_V0.8531.00
117_Y121_I0.8391.00
92_D102_D0.8271.00
59_G87_R0.8261.00
6_L36_L0.8211.00
56_V62_V0.8101.00
76_A88_W0.8071.00
35_K39_K0.7971.00
61_Y85_D0.7961.00
68_D94_K0.7921.00
99_L102_D0.7831.00
31_L34_L0.7821.00
104_A107_E0.7811.00
2_E5_A0.7731.00
3_R69_H0.7721.00
109_A112_E0.7711.00
18_G24_D0.7711.00
96_K100_H0.7701.00
134_Q139_R0.7641.00
4_E8_Y0.7641.00
13_R21_L0.7631.00
133_R141_W0.7631.00
60_V87_R0.7631.00
77_P81_D0.7601.00
92_D101_Y0.7571.00
25_L34_L0.7561.00
38_K42_R0.7501.00
65_I143_N0.7471.00
80_A101_Y0.7450.99
65_I72_L0.7400.99
96_K101_Y0.7370.99
64_W91_Y0.7360.99
43_E68_D0.7340.99
93_P96_K0.7310.99
6_L29_D0.7260.99
36_L40_V0.7250.99
91_Y104_A0.7100.99
83_F99_L0.7080.99
37_A40_V0.7070.99
21_L30_V0.7040.99
20_R24_D0.7020.99
73_P97_L0.6980.99
95_R99_L0.6970.99
72_L99_L0.6950.99
141_W144_L0.6940.99
136_M144_L0.6820.99
12_W15_L0.6810.99
76_A80_A0.6810.99
112_E119_K0.6770.99
34_L38_K0.6750.99
38_K41_R0.6700.99
96_K102_D0.6690.99
49_A75_L0.6690.99
97_L101_Y0.6680.99
41_R44_A0.6660.99
3_R36_L0.6640.99
73_P77_P0.6620.99
47_M50_F0.6600.99
98_A102_D0.6530.99
49_A135_E0.6490.99
44_A71_I0.6470.99
65_I140_Y0.6420.98
77_P99_L0.6410.98
13_R16_R0.6380.98
47_M51_V0.6260.98
42_R135_E0.6170.98
129_P132_Q0.6150.98
70_N73_P0.6150.98
29_D32_R0.6150.98
25_L31_L0.6150.98
118_Y122_F0.6130.98
62_V89_S0.6080.98
42_R45_H0.6050.98
58_D87_R0.6040.98
104_A108_D0.6030.98
13_R24_D0.6000.98
108_D111_E0.5970.98
115_K119_K0.5880.97
72_L97_L0.5860.97
26_A31_L0.5840.97
74_L77_P0.5830.97
80_A88_W0.5830.97
136_M140_Y0.5810.97
114_W141_W0.5790.97
65_I90_I0.5750.97
92_D98_A0.5740.97
70_N94_K0.5710.97
46_K68_D0.5690.97
97_L100_H0.5670.97
112_E116_T0.5610.97
113_L118_Y0.5600.96
50_F136_M0.5550.96
40_V44_A0.5540.96
54_R103_D0.5540.96
108_D112_E0.5500.96
70_N74_L0.5490.96
131_L136_M0.5490.96
21_L24_D0.5470.96
78_H90_I0.5460.96
45_H52_R0.5420.96
60_V89_S0.5400.96
27_D32_R0.5400.96
3_R6_L0.5370.96
103_D108_D0.5310.95
17_G24_D0.5310.95
29_D33_L0.5300.95
17_G22_L0.5290.95
45_H50_F0.5260.95
61_Y83_F0.5230.95
35_K38_K0.5230.95
10_Y15_L0.5230.95
13_R17_G0.5160.94
122_F132_Q0.5150.94
81_D85_D0.5140.94
24_D30_V0.5110.94
34_L41_R0.5080.94
119_K124_P0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yvlA 3 0.774 25.5 0.934 Contact Map
2xapA 4 0.8151 11.1 0.944 Contact Map
1bf5A 2 0.8493 7.4 0.948 Contact Map
2d8dA 2 0.2671 5.8 0.951 Contact Map
2r6iA 2 0.274 5.6 0.951 Contact Map
4um2A 1 0.6644 4.5 0.953 Contact Map
1y8qA 1 0.6712 4.3 0.954 Contact Map
2rioA 2 0.6849 3.2 0.956 Contact Map
3k8tA 2 0.7808 3.1 0.957 Contact Map
3hncA 2 0.7877 2.9 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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