GREMLIN Database
DoxX_2 - DoxX-like family
PFAM: PF13564 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 103 (98)
Sequences: 49225 (32653)
Seq/√Len: 3298.4
META: 0.919

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_A53_L2.7511.00
17_K45_E2.3461.00
22_P26_E2.2991.00
11_L49_A2.2721.00
15_V19_L2.1521.00
33_Y80_T2.0281.00
26_E30_H1.9501.00
48_G70_L1.8831.00
40_L44_L1.8371.00
51_G66_A1.8281.00
23_E26_E1.6551.00
7_A49_A1.6331.00
81_H86_D1.6321.00
10_F70_L1.6041.00
27_G30_H1.5111.00
14_G49_A1.5021.00
30_H86_D1.4871.00
14_G46_L1.4861.00
3_T63_T1.4821.00
88_S95_V1.4731.00
35_A38_R1.4541.00
20_G39_R1.4451.00
8_L12_F1.4401.00
22_P25_V1.4401.00
34_P37_F1.4291.00
90_A93_P1.4081.00
26_E29_A1.3981.00
12_F16_M1.3921.00
10_F74_M1.3821.00
28_F38_R1.3791.00
37_F40_L1.3681.00
35_A39_R1.3601.00
4_G8_L1.3431.00
90_A94_L1.3261.00
79_A83_R1.2421.00
49_A53_L1.2351.00
7_A11_L1.2281.00
21_P24_V1.2241.00
47_L51_G1.2171.00
29_A35_A1.2131.00
78_I93_P1.1941.00
68_A72_G1.1911.00
25_V29_A1.1881.00
23_E27_G1.1781.00
49_A70_L1.1771.00
71_A97_L1.1751.00
17_K42_G1.1681.00
43_V47_L1.1651.00
91_L95_V1.1641.00
9_F13_S1.1581.00
61_R64_E1.1491.00
88_S91_L1.1061.00
39_R43_V1.0621.00
45_E49_A1.0581.00
89_H92_F1.0191.00
71_A75_G1.0081.00
66_A69_G1.0021.00
50_I54_L0.9761.00
44_L73_Y0.9701.00
81_H93_P0.9691.00
92_F96_L0.9581.00
24_V27_G0.9501.00
45_E73_Y0.9491.00
12_F15_V0.9481.00
97_L101_W0.9181.00
28_F31_L0.9121.00
44_L75_G0.9071.00
48_G69_G0.9011.00
76_G79_A0.8961.00
93_P96_L0.8911.00
27_G31_L0.8851.00
25_V38_R0.8651.00
16_M19_L0.8621.00
31_L80_T0.8531.00
63_T67_A0.8531.00
93_P97_L0.8531.00
13_S16_M0.8451.00
13_S17_K0.8381.00
89_H93_P0.8181.00
20_G38_R0.8141.00
41_L73_Y0.8111.00
73_Y76_G0.8051.00
36_Y40_L0.8021.00
65_L69_G0.8021.00
11_L15_V0.7951.00
13_S45_E0.7901.00
51_G69_G0.7741.00
18_L42_G0.7531.00
33_Y37_F0.7441.00
70_L100_A0.7391.00
80_T84_V0.7361.00
9_F12_F0.7251.00
89_H95_V0.7241.00
86_D89_H0.7141.00
36_Y39_R0.7091.00
64_E68_A0.7091.00
15_V46_L0.7081.00
16_M21_P0.7071.00
18_L43_V0.7051.00
17_K38_R0.7041.00
92_F95_V0.7021.00
20_G23_E0.6991.00
6_L100_A0.6931.00
10_F45_E0.6881.00
88_S92_F0.6831.00
2_L99_L0.6791.00
44_L48_G0.6661.00
54_L62_L0.6601.00
5_L9_F0.6601.00
71_A101_W0.6581.00
76_G80_T0.6561.00
79_A82_L0.6551.00
78_I82_L0.6501.00
62_L65_L0.6501.00
21_P25_V0.6451.00
55_P58_R0.6421.00
14_G18_L0.6331.00
6_L10_F0.6321.00
84_V87_P0.6311.00
17_K24_V0.6301.00
37_F41_L0.6291.00
31_L84_V0.6261.00
20_G24_V0.6251.00
62_L69_G0.6171.00
61_R65_L0.6051.00
18_L46_L0.6041.00
16_M24_V0.5961.00
20_G35_A0.5941.00
93_P100_A0.5871.00
14_G42_G0.5861.00
74_M77_A0.5841.00
18_L39_R0.5741.00
48_G51_G0.5691.00
33_Y79_A0.5661.00
69_G72_G0.5631.00
5_L8_L0.5621.00
41_L45_E0.5521.00
3_T7_A0.5521.00
91_L94_L0.5501.00
64_E67_A0.5331.00
88_S94_L0.5301.00
21_P39_R0.5261.00
92_F99_L0.5251.00
3_T67_A0.5211.00
11_L46_L0.5161.00
94_L98_A0.5101.00
96_L100_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i0uA 4 0.5534 2.4 0.891 Contact Map
4ev6A 3 0.5728 2.4 0.891 Contact Map
2ww9A 1 0.8641 1.8 0.898 Contact Map
3dinC 1 0.8835 1.5 0.902 Contact Map
3dl8G 1 0.8641 1.4 0.905 Contact Map
3j01A 1 0.8641 1.4 0.905 Contact Map
4qncA 2 0.6505 1.3 0.908 Contact Map
2nq2A 2 0.9223 1.2 0.908 Contact Map
3x29A 1 0.534 1.2 0.908 Contact Map
2mpnA 2 0.3301 1.2 0.909 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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