GREMLIN Database
NTP_transf_4 - Sugar nucleotidyl transferase
PFAM: PF13562 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 156 (151)
Sequences: 7570 (6104)
Seq/√Len: 496.8
META: 0.937

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_D32_R3.3321.00
13_L17_L3.3011.00
141_G145_R3.0691.00
143_A146_A2.9151.00
131_E135_D2.4851.00
32_R36_E2.4131.00
34_K143_A2.3411.00
87_K90_E2.2411.00
128_L139_L2.2151.00
24_L136_I2.1731.00
31_I34_K2.0661.00
90_E119_E1.9961.00
135_D138_S1.9771.00
32_R46_F1.9311.00
16_T24_L1.9161.00
29_L150_L1.9151.00
34_K147_D1.8861.00
11_N132_Y1.8471.00
64_D102_R1.8401.00
97_E131_E1.7941.00
9_R49_R1.7751.00
72_R129_L1.7081.00
15_L24_L1.6731.00
29_L34_K1.6621.00
38_Y77_E1.6411.00
128_L142_E1.6361.00
72_R97_E1.6001.00
128_L143_A1.5561.00
139_L142_E1.5491.00
37_R150_L1.5351.00
22_A71_G1.5341.00
12_L21_V1.5201.00
73_V129_L1.5141.00
29_L37_R1.5021.00
73_V99_I1.4951.00
82_A123_Y1.4731.00
4_F68_L1.4571.00
94_K127_V1.4361.00
22_A46_F1.3821.00
142_E145_R1.3761.00
6_D70_N1.3721.00
1_I67_L1.3711.00
5_D49_R1.3541.00
6_D72_R1.3341.00
26_C143_A1.3261.00
91_A98_L1.3221.00
9_R13_L1.3201.00
13_L16_T1.2971.00
145_R149_E1.2911.00
36_E44_V1.2771.00
68_L103_L1.2761.00
4_F98_L1.2741.00
25_R28_I1.2541.00
97_E129_L1.2461.00
29_L33_E1.2431.00
93_V98_L1.2401.00
68_L101_A1.2351.00
135_D139_L1.2151.00
132_Y135_D1.2101.00
98_L101_A1.2071.00
148_F152_T1.1801.00
142_E146_A1.1581.00
140_N144_I1.1521.00
26_C31_I1.1421.00
12_L130_I1.1211.00
77_E81_E1.1191.00
73_V127_V1.0831.00
33_E36_E1.0751.00
45_S66_N1.0601.00
60_V66_N1.0501.00
78_E125_G1.0451.00
93_V120_L1.0401.00
92_L100_A1.0391.00
23_D46_F1.0341.00
146_A149_E1.0221.00
91_A94_K1.0151.00
8_A11_N1.0141.00
73_V79_L1.0041.00
25_R30_T1.0011.00
74_L130_I0.9931.00
30_T33_E0.9881.00
1_I44_V0.9871.00
38_Y150_L0.9771.00
47_L68_L0.9771.00
12_L133_P0.9651.00
93_V96_G0.9641.00
11_N131_E0.9521.00
3_L32_R0.9281.00
25_R33_E0.9261.00
9_R15_L0.9241.00
3_L35_W0.9211.00
29_L151_L0.9161.00
67_L102_R0.9151.00
5_D22_A0.9141.00
36_E43_T0.9081.00
2_I66_N0.9081.00
16_T21_V0.9041.00
28_I151_L0.9031.00
41_A44_V0.8971.00
28_I144_I0.8931.00
21_V71_G0.8921.00
20_P46_F0.8881.00
76_N146_A0.8811.00
21_V72_R0.8781.00
12_L72_R0.8761.00
83_I100_A0.8741.00
130_I139_L0.8561.00
74_L128_L0.8531.00
1_I69_I0.8501.00
121_I124_E0.8491.00
74_L143_A0.8251.00
15_L133_P0.8231.00
90_E121_I0.8191.00
53_S58_L0.8161.00
76_N123_Y0.8111.00
58_L61_I0.8091.00
2_I68_L0.8081.00
26_C136_I0.8061.00
112_L115_L0.8051.00
26_C74_L0.8051.00
94_K126_E0.8011.00
94_K97_E0.8001.00
86_L92_L0.7971.00
47_L50_D0.7911.00
26_C130_I0.7741.00
103_L107_Q0.7661.00
29_L143_A0.7641.00
108_L111_L0.7641.00
39_L80_V0.7641.00
8_A72_R0.7641.00
130_I136_I0.7641.00
141_G144_I0.7531.00
137_F140_N0.7481.00
89_G92_L0.7481.00
15_L19_R0.7421.00
62_P66_N0.7371.00
12_L24_L0.7361.00
137_F141_G0.7341.00
19_R24_L0.7341.00
88_P102_R0.7281.00
149_E153_K0.7281.00
82_A125_G0.7261.00
32_R44_V0.7201.00
25_R29_L0.7171.00
5_D9_R0.7171.00
109_E112_L0.7151.00
31_I74_L0.7081.00
111_L115_L0.7051.00
80_V84_K0.7041.00
35_W75_P0.7001.00
15_L136_I0.6991.00
104_S107_Q0.6961.00
35_W39_L0.6891.00
31_I71_G0.6841.00
61_I64_D0.6821.00
9_R21_V0.6601.00
81_E84_K0.6591.00
1_I39_L0.6541.00
53_S56_F0.6531.00
82_A92_L0.6511.00
86_L100_A0.6501.00
28_I148_F0.6481.00
53_S57_P0.6461.00
22_A48_T0.6431.00
54_E57_P0.6431.00
26_C140_N0.6421.00
130_I135_D0.6411.00
79_L83_I0.6391.00
55_K58_L0.6381.00
35_W69_I0.6371.00
3_L44_V0.6351.00
120_L124_E0.6311.00
10_E49_R0.6271.00
140_N143_A0.6251.00
20_P55_K0.6251.00
88_P104_S0.6251.00
89_G104_S0.6241.00
23_D56_F0.6241.00
10_E13_L0.6201.00
123_Y127_V0.6161.00
70_N129_L0.6110.99
4_F70_N0.6070.99
23_D30_T0.6050.99
128_L146_A0.6000.99
77_E149_E0.5940.99
61_I66_N0.5930.99
63_D66_N0.5840.99
48_T56_F0.5810.99
69_I100_A0.5800.99
3_L36_E0.5770.99
31_I75_P0.5770.99
130_I133_P0.5720.99
71_G75_P0.5660.99
54_E58_L0.5630.99
134_W138_S0.5630.99
90_E93_V0.5560.99
143_A147_D0.5560.99
111_L114_D0.5540.99
70_N97_E0.5500.99
22_A47_L0.5500.99
38_Y80_V0.5460.99
21_V24_L0.5420.99
34_K74_L0.5410.99
48_T52_L0.5380.99
94_K129_L0.5380.99
26_C139_L0.5320.99
39_L84_K0.5300.99
2_I45_S0.5290.99
78_E82_A0.5230.98
27_G144_I0.5220.98
91_A101_A0.5190.98
16_T19_R0.5180.98
3_L22_A0.5180.98
18_T51_Y0.5170.98
60_V63_D0.5160.98
20_P52_L0.5150.98
119_E122_E0.5140.98
111_L117_E0.5120.98
20_P71_G0.5120.98
75_P80_V0.5110.98
8_A131_E0.5080.98
34_K75_P0.5070.98
107_Q115_L0.5060.98
75_P79_L0.5040.98
22_A32_R0.5040.98
15_L18_T0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wdiA 1 0.6667 7.4 0.931 Contact Map
1vkyA 2 0.6731 6 0.934 Contact Map
3d8lA 2 0.25 4.9 0.937 Contact Map
3pqaA 4 0.4744 3.8 0.94 Contact Map
1mc3A 3 0.9295 3.8 0.94 Contact Map
4trhA 2 0.5449 3.8 0.94 Contact Map
2c42A 2 0.9872 3.6 0.941 Contact Map
1lvwA 3 0.9231 3.4 0.942 Contact Map
4ho4A 3 0.9295 3 0.943 Contact Map
1na6A 2 0.5577 2.9 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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