GREMLIN Database
DUF4126 - Domain of unknown function (DUF4126)
PFAM: PF13548 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 176 (169)
Sequences: 13208 (7893)
Seq/√Len: 607.2
META: 0.92

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_A41_G4.0511.00
125_V137_V3.9161.00
20_L50_G3.2101.00
61_K139_L2.9071.00
27_R43_P2.8901.00
43_P47_G2.7721.00
168_V172_W2.6931.00
21_V149_S2.5601.00
42_S45_V2.3811.00
35_P38_A2.3171.00
157_V161_V2.2361.00
59_A65_V2.2201.00
23_G46_L2.1681.00
44_W47_G2.0441.00
10_A148_L2.0361.00
24_L28_F1.9031.00
129_P133_S1.9031.00
81_G107_G1.8651.00
74_T115_H1.8411.00
120_G124_A1.7621.00
24_L46_L1.7391.00
159_A163_V1.6351.00
25_A30_W1.5761.00
148_L159_A1.5381.00
112_L116_G1.5321.00
150_W154_L1.5051.00
169_L173_L1.4991.00
70_D73_H1.4991.00
27_R46_L1.4981.00
78_P112_L1.4681.00
139_L143_V1.4631.00
4_A8_A1.4541.00
132_F135_P1.4391.00
61_K142_D1.4281.00
46_L50_G1.4211.00
109_G113_A1.4081.00
47_G51_V1.4031.00
120_G123_A1.3851.00
26_A33_L1.3781.00
136_V140_A1.3731.00
38_A41_G1.3541.00
115_H118_K1.3251.00
14_R53_A1.3081.00
43_P46_L1.2941.00
126_N134_N1.2861.00
85_A89_A1.2631.00
101_V105_L1.2581.00
132_F136_V1.2541.00
75_F78_P1.2321.00
20_L46_L1.2271.00
73_H76_I1.2241.00
24_L50_G1.2241.00
136_V139_L1.2231.00
22_L84_L1.2091.00
169_L172_W1.1961.00
117_A120_G1.1941.00
11_A18_P1.1941.00
116_G120_G1.1931.00
115_H119_A1.1891.00
145_A149_S1.1871.00
130_E133_S1.1861.00
2_A160_L1.1831.00
119_A123_A1.1811.00
15_L59_A1.1721.00
100_W104_A1.1691.00
124_A127_A1.1671.00
133_S136_V1.1631.00
96_P99_A1.1561.00
135_P139_L1.1541.00
19_L49_A1.1511.00
21_V25_A1.1331.00
54_L58_V1.1271.00
123_A127_A1.1051.00
140_A144_L1.1011.00
71_A75_F1.0951.00
144_L148_L1.0941.00
89_A92_L1.0901.00
155_H158_L1.0891.00
164_A168_V1.0761.00
160_L164_A1.0761.00
150_W155_H1.0651.00
125_V133_S1.0621.00
27_R41_G1.0581.00
62_I65_V1.0541.00
121_T124_A1.0501.00
110_V113_A1.0481.00
96_P100_W1.0481.00
68_L71_A1.0411.00
86_A104_A1.0391.00
74_T119_A1.0361.00
47_G50_G1.0161.00
81_G111_A1.0131.00
53_A57_F1.0121.00
45_V48_A0.9971.00
72_V75_F0.9831.00
117_A121_T0.9731.00
44_W48_A0.9701.00
22_L31_L0.9631.00
140_A143_V0.9631.00
98_A101_V0.9551.00
77_R118_K0.9551.00
99_A102_L0.9531.00
80_A84_L0.9451.00
67_S71_A0.9451.00
15_L80_A0.9441.00
113_A116_G0.9431.00
91_D96_P0.9411.00
152_A159_A0.9371.00
11_A80_A0.9331.00
20_L53_A0.9321.00
57_F139_L0.9311.00
32_D35_P0.9301.00
160_L163_V0.9281.00
130_E134_N0.9141.00
40_L87_A0.9051.00
138_S142_D0.9031.00
165_L169_L0.9021.00
51_V55_V0.9011.00
10_A149_S0.8981.00
121_T125_V0.8941.00
85_A88_A0.8871.00
101_V104_A0.8831.00
168_V171_V0.8831.00
167_L171_V0.8801.00
7_L22_L0.8791.00
143_V146_V0.8691.00
124_A128_S0.8681.00
59_A69_W0.8631.00
67_S126_N0.8601.00
116_G119_A0.8581.00
10_A18_P0.8461.00
82_A104_A0.8451.00
8_A85_A0.8291.00
2_A6_G0.8261.00
114_V117_A0.8201.00
125_V128_S0.8141.00
110_V114_V0.8141.00
161_V165_L0.8131.00
149_S153_L0.8071.00
20_L24_L0.8061.00
89_A103_A0.8061.00
4_A7_L0.8061.00
5_L14_R0.7901.00
166_L170_A0.7871.00
158_L161_V0.7871.00
60_D138_S0.7811.00
126_N130_E0.7661.00
98_A102_L0.7611.00
100_W103_A0.7601.00
151_L155_H0.7541.00
165_L168_V0.7531.00
58_V62_I0.7531.00
75_F79_P0.7511.00
40_L49_A0.7431.00
166_L173_L0.7421.00
67_S70_D0.7371.00
74_T78_P0.7321.00
66_D134_N0.7301.00
25_A29_G0.7251.00
83_L87_A0.7211.00
137_V140_A0.7171.00
82_A108_G0.7141.00
159_A166_L0.7141.00
42_S46_L0.7081.00
29_G32_D0.7071.00
45_V105_L0.7071.00
117_A170_A0.7061.00
34_P37_L0.7041.00
45_V49_A0.7011.00
6_G152_A0.6991.00
85_A107_G0.6981.00
81_G85_A0.6791.00
20_L49_A0.6781.00
22_L26_A0.6781.00
19_L80_A0.6661.00
151_L154_L0.6621.00
134_N137_V0.6591.00
55_V59_A0.6561.00
48_A52_L0.6561.00
57_F142_D0.6521.00
131_P134_N0.6501.00
143_V147_G0.6481.00
60_D142_D0.6441.00
22_L40_L0.6441.00
128_S133_S0.6421.00
148_L152_A0.6401.00
17_A146_V0.6381.00
166_L172_W0.6361.00
23_G27_R0.6331.00
9_A13_L0.6331.00
91_D99_A0.6251.00
92_L97_P0.6201.00
8_A110_V0.6201.00
129_P132_F0.6191.00
110_V163_V0.6171.00
62_I66_D0.6161.00
158_L162_L0.6121.00
51_V54_L0.6101.00
49_A53_A0.6101.00
86_A103_A0.6071.00
7_L84_L0.6061.00
97_P100_W0.5991.00
121_T137_V0.5951.00
89_A96_P0.5861.00
113_A117_A0.5861.00
114_V118_K0.5851.00
58_V65_V0.5851.00
29_G41_G0.5821.00
10_A145_A0.5821.00
122_R134_N0.5821.00
129_P135_P0.5811.00
48_A97_P0.5811.00
170_A173_L0.5801.00
131_P135_P0.5801.00
17_A53_A0.5791.00
70_D119_A0.5791.00
39_W45_V0.5771.00
67_S119_A0.5731.00
56_E141_E0.5721.00
10_A152_A0.5711.00
82_A85_A0.5711.00
21_V146_V0.5701.00
91_D100_W0.5681.00
70_D118_K0.5641.00
97_P101_V0.5631.00
25_A153_L0.5621.00
103_A110_V0.5591.00
124_A129_P0.5591.00
74_T77_R0.5571.00
114_V119_A0.5480.99
126_N129_P0.5480.99
73_H78_P0.5460.99
15_L73_H0.5450.99
15_L76_I0.5450.99
101_V106_L0.5430.99
23_G49_A0.5350.99
78_P115_H0.5320.99
23_G45_V0.5310.99
16_Y52_L0.5270.99
55_V65_V0.5270.99
14_R56_E0.5240.99
25_A28_F0.5240.99
148_L162_L0.5220.99
125_V134_N0.5150.99
26_A32_D0.5150.99
3_L97_P0.5140.99
129_P134_N0.5130.99
60_D122_R0.5130.99
69_W118_K0.5120.99
106_L109_G0.5110.99
5_L110_V0.5080.99
110_V117_A0.5060.99
125_V129_P0.5020.99
23_G50_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l2tA 2 0.2102 5 0.932 Contact Map
2ks1B 1 0.2102 2.7 0.941 Contact Map
2m20A 2 0.1591 2.1 0.943 Contact Map
1iflA 10 0.267 2 0.944 Contact Map
1ifkA 9 0.2557 2 0.944 Contact Map
4p6vD 1 0.8011 1.6 0.947 Contact Map
2l9uA 2 0.1761 1.5 0.948 Contact Map
1zcdA 1 0.9659 1.5 0.948 Contact Map
4czbA 2 0.9602 1.4 0.949 Contact Map
4xk8I 1 0.1648 1.4 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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