GREMLIN Database
FUSC_2 - Fusaric acid resistance protein-like
PFAM: PF13515 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 129 (123)
Sequences: 33402 (22230)
Seq/√Len: 2004.4
META: 0.752

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_A116_V2.7121.00
87_Q91_T2.3421.00
39_R119_T2.3111.00
113_L117_L2.1981.00
6_A14_P2.1251.00
20_T119_T2.0151.00
13_H16_W2.0001.00
86_A90_I1.9901.00
62_L65_A1.9371.00
34_R38_Q1.9091.00
40_L120_L1.8331.00
36_A123_I1.8301.00
28_S31_A1.7581.00
36_A127_L1.7061.00
61_P65_A1.7061.00
33_L36_A1.6891.00
67_L71_A1.6881.00
89_A92_A1.6591.00
4_L8_L1.6071.00
94_I98_L1.5871.00
87_Q90_I1.5841.00
110_D114_D1.5361.00
70_L74_L1.5331.00
45_L88_A1.5241.00
17_A118_D1.5221.00
122_G126_A1.5141.00
47_A112_A1.5041.00
35_R83_Y1.4881.00
72_V75_A1.4451.00
66_L70_L1.4241.00
71_A75_A1.4171.00
46_G50_G1.3991.00
3_L7_R1.3991.00
66_L69_A1.3801.00
40_L123_I1.3711.00
120_L124_A1.3681.00
114_D117_L1.3571.00
82_N85_L1.3481.00
71_A74_L1.3431.00
15_Y18_V1.3071.00
37_L41_L1.3041.00
44_L116_V1.3041.00
76_A79_R1.2971.00
84_A87_Q1.2971.00
17_A125_V1.2591.00
69_A73_L1.2591.00
62_L66_L1.2491.00
73_L77_L1.2461.00
83_Y87_Q1.2371.00
4_L7_R1.2351.00
67_L70_L1.2311.00
55_A58_P1.2121.00
85_L89_A1.2111.00
48_V52_L1.2111.00
107_G110_D1.2081.00
63_A66_L1.1791.00
43_T115_R1.1721.00
51_L112_A1.1491.00
55_A59_G1.1391.00
116_V120_L1.1341.00
61_P64_L1.1201.00
5_I125_V1.1021.00
5_I9_L1.0991.00
52_L56_L1.0771.00
26_Q35_R1.0731.00
70_L73_L1.0401.00
109_W112_A1.0381.00
52_L55_A1.0341.00
50_G54_L1.0241.00
86_A89_A1.0101.00
43_T119_T1.0051.00
16_W118_D1.0021.00
74_L77_L0.9991.00
43_T91_T0.9871.00
73_L76_A0.9701.00
6_A11_L0.9661.00
114_D118_D0.9451.00
20_T24_V0.9421.00
5_I8_L0.9371.00
92_A95_V0.9371.00
7_R10_G0.9311.00
88_A92_A0.9311.00
6_A10_G0.9301.00
20_T39_R0.9211.00
93_L97_L0.8961.00
106_G110_D0.8931.00
45_L48_V0.8911.00
92_A98_L0.8851.00
12_P114_D0.8781.00
118_D121_I0.8721.00
16_W111_L0.8701.00
88_A91_T0.8681.00
71_A92_A0.8661.00
89_A93_L0.8621.00
59_G63_A0.8461.00
68_V71_A0.8411.00
29_V33_L0.8351.00
90_I93_L0.8301.00
85_L90_I0.8291.00
92_A96_L0.8211.00
8_L11_L0.8151.00
93_L96_L0.8141.00
72_V76_A0.8121.00
92_A97_L0.8031.00
113_L116_V0.8011.00
29_V32_T0.7821.00
6_A9_L0.7781.00
13_H114_D0.7771.00
90_I94_I0.7761.00
19_L23_I0.7751.00
38_Q84_A0.7721.00
17_A121_I0.7701.00
86_A91_T0.7621.00
82_N86_A0.7591.00
105_P108_P0.7551.00
16_W43_T0.7521.00
65_A69_A0.7491.00
3_L18_V0.7381.00
26_Q32_T0.7341.00
21_A126_A0.7311.00
93_L98_L0.7301.00
7_R12_P0.7291.00
96_L99_A0.7281.00
25_L126_A0.7271.00
117_L121_I0.7211.00
57_F60_P0.7081.00
115_R118_D0.7051.00
92_A99_A0.6961.00
24_V36_A0.6961.00
109_W113_L0.6911.00
83_Y86_A0.6861.00
14_P17_A0.6801.00
121_I125_V0.6761.00
55_A60_P0.6761.00
84_A88_A0.6741.00
22_L26_Q0.6571.00
6_A18_V0.6551.00
84_A89_A0.6461.00
17_A21_A0.6461.00
37_L40_L0.6421.00
94_I99_A0.6411.00
41_L44_L0.6371.00
98_L101_L0.6341.00
123_I127_L0.6231.00
3_L11_L0.6231.00
43_T118_D0.6211.00
86_A94_I0.6201.00
91_T98_L0.6201.00
44_L48_V0.6131.00
11_L118_D0.6091.00
85_L91_T0.6091.00
106_G109_W0.6001.00
67_L75_A0.5991.00
15_Y19_L0.5981.00
42_G46_G0.5951.00
24_V126_A0.5891.00
14_P118_D0.5851.00
121_I124_A0.5831.00
124_A128_L0.5821.00
58_P63_A0.5801.00
48_V51_L0.5771.00
79_R86_A0.5761.00
36_A40_L0.5751.00
38_Q41_L0.5631.00
95_V99_A0.5621.00
97_L100_L0.5581.00
65_A71_A0.5581.00
28_S32_T0.5531.00
50_G96_L0.5471.00
23_I119_T0.5401.00
49_L88_A0.5381.00
88_A95_V0.5341.00
26_Q29_V0.5331.00
91_T99_A0.5271.00
125_V128_L0.5271.00
60_P63_A0.5271.00
78_L81_R0.5261.00
35_R38_Q0.5221.00
76_A80_R0.5171.00
31_A34_R0.5141.00
46_G88_A0.5141.00
65_A68_V0.5131.00
68_V76_A0.5121.00
16_W20_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i88A 1 0.3333 4.9 0.889 Contact Map
4f35D 2 0.7054 2.5 0.904 Contact Map
4qtnA 3 0.9767 2 0.909 Contact Map
4pgrA 1 0.7674 1.5 0.915 Contact Map
4wrtA 1 0.1705 1.2 0.921 Contact Map
2mpnA 2 0.1783 1 0.925 Contact Map
3k3fA 3 0.7364 0.9 0.925 Contact Map
3gd8A 4 0.4651 0.7 0.931 Contact Map
4jkvA 2 0.2946 0.7 0.931 Contact Map
2xq2A 2 0.9612 0.7 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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