GREMLIN Database
DUF4124 - Domain of unknown function (DUF4124)
PFAM: PF13511 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 56 (51)
Sequences: 37404 (30232)
Seq/√Len: 4233.4
META: 0.95

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_K24_V4.7101.00
18_V24_V4.3391.00
17_W25_H3.1331.00
17_W31_P2.9121.00
19_D23_V2.6521.00
17_W27_S2.4451.00
19_D25_H1.5691.00
31_P34_G1.4131.00
27_S30_P1.3151.00
16_K26_Y1.2941.00
17_W24_V1.2721.00
7_A10_A1.2571.00
38_E42_P1.2501.00
8_A11_A1.1721.00
31_P35_A1.1631.00
9_A12_A1.0471.00
45_P48_A1.0371.00
15_Y27_S1.0191.00
42_P45_P1.0131.00
6_A9_A1.0121.00
7_A11_A0.9611.00
33_A36_K0.9041.00
33_A37_A0.9011.00
41_E44_P0.8991.00
48_A51_P0.8861.00
14_I26_Y0.8821.00
31_P36_K0.8821.00
48_A52_A0.8721.00
49_P52_A0.8651.00
17_W28_D0.8651.00
32_P37_A0.8611.00
6_A10_A0.8601.00
10_A13_Q0.8471.00
47_A50_A0.8411.00
26_Y29_T0.8061.00
46_P49_P0.8061.00
15_Y29_T0.7931.00
32_P35_A0.7691.00
11_A14_I0.7341.00
25_H28_D0.7281.00
45_P49_P0.7261.00
21_D25_H0.7091.00
4_L7_A0.7081.00
17_W20_A0.7061.00
14_I17_W0.7021.00
4_L8_A0.7011.00
31_P37_A0.7001.00
34_G37_A0.6841.00
44_P47_A0.6801.00
43_A46_P0.6651.00
5_L9_A0.6461.00
2_L5_L0.6391.00
6_A11_A0.6311.00
17_W32_P0.6241.00
47_A51_P0.6231.00
40_V43_A0.6161.00
6_A12_A0.6151.00
42_P47_A0.6141.00
13_Q30_P0.6051.00
37_A40_V0.6001.00
17_W37_A0.5941.00
43_A47_A0.5861.00
44_P52_A0.5801.00
15_Y30_P0.5751.00
42_P46_P0.5721.00
35_A38_E0.5711.00
14_I28_D0.5631.00
3_L6_A0.5581.00
44_P48_A0.5511.00
15_Y28_D0.5431.00
5_L30_P0.5411.00
2_L6_A0.5371.00
14_I29_T0.5261.00
5_L10_A0.5151.00
38_E41_E0.5071.00
32_P38_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qwyA 1 0.9821 14.2 0.79 Contact Map
4iiwA 4 0.6786 13.7 0.791 Contact Map
3ab4A 7 0.9643 9.5 0.806 Contact Map
2r1fA 4 0.8929 8.2 0.811 Contact Map
3tviA 2 0.9643 7.6 0.814 Contact Map
1e19A 2 0.9643 7.3 0.816 Contact Map
4axsA 2 0.9643 6.6 0.82 Contact Map
2cdqA 2 0.9643 6.4 0.821 Contact Map
3c1mA 3 0.9643 6.1 0.822 Contact Map
2a1fA 5 0.875 6.1 0.823 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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