GREMLIN Database
DUF4123 - Domain of unknown function (DUF4123)
PFAM: PF13503 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 119 (115)
Sequences: 5018 (4100)
Seq/√Len: 382.3
META: 0.672

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_D95_L4.7091.00
73_P76_E3.4781.00
113_T116_E2.5261.00
9_R63_S2.4171.00
106_R110_P2.3631.00
108_L116_E2.3441.00
105_L109_L2.3401.00
86_T94_R2.2591.00
101_D104_V2.2011.00
98_R101_D2.0321.00
88_R94_R2.0061.00
80_H84_F1.9891.00
97_F108_L1.9131.00
39_A42_A1.8881.00
108_L112_C1.8811.00
3_A67_F1.8081.00
10_D13_L1.7961.00
78_R82_R1.7381.00
72_A76_E1.7191.00
54_L58_L1.7161.00
52_S55_L1.7081.00
85_L99_F1.6131.00
56_R60_E1.6031.00
74_L78_R1.5881.00
86_T96_L1.5831.00
85_L100_Y1.5701.00
31_R78_R1.5581.00
23_E47_R1.5141.00
111_T116_E1.4561.00
63_S103_R1.3891.00
114_P117_L1.3861.00
17_L46_V1.3831.00
72_A77_L1.3341.00
30_Y96_L1.3001.00
14_L18_Y1.2591.00
16_L57_W1.2391.00
48_L55_L1.2201.00
7_G44_Y1.2181.00
89_D92_G1.2121.00
10_D14_L1.2041.00
68_L81_L1.1991.00
53_P56_R1.1871.00
33_T36_A1.1651.00
21_G24_H1.1591.00
98_R103_R1.1461.00
18_Y21_G1.1231.00
107_A110_P1.1091.00
45_L74_L1.1001.00
30_Y100_Y1.0801.00
38_L41_V1.0751.00
54_L57_W1.0691.00
55_L58_L1.0641.00
4_L45_L1.0631.00
72_A80_H1.0621.00
68_L77_L1.0571.00
77_L81_L1.0551.00
15_A18_Y1.0461.00
5_L65_G1.0341.00
57_W60_E1.0301.00
87_V95_L1.0241.00
4_L81_L1.0071.00
107_A111_T1.0001.00
16_L19_E0.9881.00
9_R13_L0.9681.00
112_C116_E0.9441.00
32_G82_R0.9321.00
89_D93_R0.9241.00
25_R75_E0.9201.00
104_V108_L0.9051.00
30_Y86_T0.8961.00
62_K65_G0.8871.00
26_C44_Y0.8811.00
35_E41_V0.8671.00
20_S24_H0.8651.00
74_L77_L0.8621.00
23_E26_C0.8571.00
109_L112_C0.8501.00
18_Y24_H0.8461.00
88_R92_G0.8411.00
70_S77_L0.8241.00
85_L96_L0.8231.00
43_P46_V0.8231.00
82_R85_L0.8201.00
45_L78_R0.8151.00
35_E96_L0.8141.00
35_E39_A0.8121.00
31_R82_R0.8071.00
2_Y74_L0.8041.00
55_L59_L0.8031.00
49_E52_S0.7761.00
24_H27_S0.7721.00
7_G10_D0.7641.00
4_L99_F0.7631.00
9_R12_D0.7501.00
58_L67_F0.7501.00
13_L64_W0.7391.00
12_D15_A0.7381.00
30_Y43_P0.7361.00
39_A44_Y0.7361.00
30_Y85_L0.7301.00
6_D100_Y0.7271.00
97_F104_V0.7261.00
12_D18_Y0.7261.00
108_L111_T0.7181.00
53_P60_E0.7111.00
4_L66_I0.7061.00
30_Y98_R0.7041.00
10_D62_K0.7031.00
27_S74_L0.7011.00
25_R74_L0.6940.99
25_R47_R0.6870.99
89_D94_R0.6830.99
67_F70_S0.6820.99
20_S26_C0.6800.99
25_R78_R0.6710.99
14_L40_E0.6660.99
3_A48_L0.6600.99
37_E40_E0.6590.99
12_D16_L0.6570.99
15_A19_E0.6480.99
37_E41_V0.6430.99
5_L46_V0.6420.99
30_Y42_A0.6380.99
6_D98_R0.6370.99
54_L59_L0.6290.99
35_E86_T0.6210.99
23_E50_P0.6200.99
54_L60_E0.6200.99
14_L21_G0.6180.99
63_S106_R0.6180.99
3_A46_V0.6180.99
61_G65_G0.6170.99
109_L117_L0.6140.99
45_L77_L0.6130.99
73_P77_L0.6090.99
36_A39_A0.6010.98
27_S78_R0.5910.98
97_F100_Y0.5910.98
62_K66_I0.5870.98
6_D101_D0.5820.98
7_G14_L0.5780.98
21_G49_E0.5750.98
81_L84_F0.5710.98
17_L21_G0.5650.98
112_C117_L0.5640.98
51_D58_L0.5610.98
14_L24_H0.5540.97
31_R34_L0.5510.97
14_L20_S0.5510.97
22_P25_R0.5450.97
50_P75_E0.5400.97
7_G13_L0.5380.97
51_D54_L0.5340.97
10_D15_A0.5320.97
8_A26_C0.5270.97
9_R42_A0.5170.96
3_A10_D0.5170.96
51_D71_P0.5150.96
63_S66_I0.5150.96
19_E22_P0.5130.96
88_R93_R0.5120.96
40_E70_S0.5110.96
75_E115_E0.5100.96
8_A41_V0.5080.96
8_A61_G0.5070.96
96_L99_F0.5050.96
53_P59_L0.5050.96
5_L10_D0.5050.96
70_S73_P0.5020.95
16_L20_S0.5020.95
13_L17_L0.5010.95
100_Y106_R0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4v194 1 0.3277 26.1 0.867 Contact Map
4fhrB 1 0.3782 5.1 0.904 Contact Map
4bmaA 1 0.2941 3.8 0.91 Contact Map
1pnuU 1 0.2437 2.4 0.918 Contact Map
4euwA 1 0.4202 2.3 0.919 Contact Map
3ogzA 1 0.3277 2 0.922 Contact Map
2h9aA 1 0.6807 1.8 0.924 Contact Map
3ujmA 2 0.3697 1.8 0.924 Contact Map
4zuzA 1 0.9244 1.7 0.925 Contact Map
4p6zM 1 0.3277 1.7 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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