GREMLIN Database
AsmA_2 - AsmA-like C-terminal region
PFAM: PF13502 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 230 (216)
Sequences: 33983 (25631)
Seq/√Len: 1743.9
META: 0.89

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_V167_T3.0961.00
47_D77_D3.0901.00
23_N28_T2.8061.00
49_K75_D2.7721.00
3_N23_N2.6171.00
97_S140_D2.5491.00
169_D172_T2.4601.00
96_G141_F2.2471.00
48_L76_L2.1941.00
80_G91_S2.1591.00
45_S79_S2.1541.00
95_T142_T2.1261.00
140_D152_D2.1101.00
14_V34_S2.1051.00
142_T151_D2.0311.00
149_T167_T2.0191.00
5_S21_S1.9991.00
16_R34_S1.9941.00
21_S30_S1.9841.00
143_I148_A1.9791.00
99_S138_S1.9291.00
150_T177_L1.9121.00
21_S28_T1.8961.00
9_R18_D1.8751.00
14_V36_D1.8271.00
54_D57_A1.8211.00
169_D174_T1.8141.00
18_D32_S1.8051.00
32_S47_D1.8051.00
114_D117_L1.7891.00
22_A29_L1.7581.00
153_L164_G1.7331.00
56_G69_S1.7121.00
147_V169_D1.7081.00
141_F148_A1.7011.00
144_K149_T1.6871.00
93_N144_K1.6751.00
50_L53_V1.6751.00
43_R81_P1.6471.00
51_D73_S1.6471.00
166_G177_L1.6411.00
7_K18_D1.6411.00
34_S45_S1.6361.00
154_V163_T1.6151.00
26_G57_A1.6111.00
7_K19_P1.6031.00
113_F116_G1.5861.00
104_R131_G1.5491.00
75_D97_S1.5371.00
69_S106_L1.5131.00
150_T153_L1.5041.00
114_D119_S1.4901.00
69_S104_R1.4581.00
100_L103_G1.4571.00
156_D161_R1.4561.00
116_G119_S1.4531.00
52_G71_K1.4411.00
54_D71_K1.4381.00
98_L139_G1.4361.00
77_D95_T1.4331.00
104_R133_A1.4151.00
45_S77_D1.4121.00
9_R16_R1.3861.00
10_L15_L1.3551.00
127_L130_K1.3161.00
139_G153_L1.2961.00
136_D156_D1.2541.00
206_K209_G1.2531.00
84_S87_P1.2521.00
142_T149_T1.2501.00
182_T217_T1.2421.00
14_V38_R1.2231.00
46_L78_L1.2181.00
5_S19_P1.2151.00
79_S93_N1.2081.00
47_D75_D1.2031.00
135_D156_D1.1981.00
83_A87_P1.1941.00
168_V177_L1.1871.00
25_Y61_A1.1821.00
164_G179_L1.1821.00
103_G134_F1.1781.00
106_L131_G1.1711.00
28_T51_D1.1691.00
140_D151_D1.1651.00
80_G88_L1.1631.00
180_T219_P1.1581.00
178_R221_R1.1461.00
100_L134_F1.1451.00
30_S49_K1.1381.00
115_L118_L1.1351.00
97_S138_S1.1141.00
154_V161_R1.1131.00
121_A124_F1.1051.00
115_L119_S1.0971.00
173_E227_D1.0811.00
44_F80_G1.0791.00
164_G168_V1.0761.00
19_P33_G1.0731.00
94_G143_I1.0711.00
99_S136_D1.0621.00
157_G160_A1.0601.00
43_R79_S1.0581.00
173_E226_W1.0571.00
17_L20_L1.0451.00
111_L114_D1.0441.00
165_S178_R1.0311.00
167_T176_D1.0241.00
174_T225_T1.0231.00
16_R32_S1.0231.00
189_G193_G1.0131.00
171_D174_T1.0071.00
179_L222_V1.0071.00
30_S51_D1.0001.00
81_P91_S0.9991.00
176_D221_R0.9971.00
44_F48_L0.9941.00
36_D43_R0.9921.00
134_F137_L0.9871.00
19_P30_S0.9871.00
86_A90_A0.9821.00
114_D118_L0.9741.00
26_G54_D0.9681.00
120_L124_F0.9601.00
207_L210_K0.9551.00
111_L119_S0.9461.00
141_F150_T0.9451.00
50_L74_L0.9411.00
135_D158_P0.9331.00
37_A42_P0.9301.00
161_R182_T0.9281.00
57_A60_K0.9241.00
71_K102_D0.9201.00
90_A171_D0.9161.00
178_R219_P0.9161.00
101_R136_D0.9111.00
11_K14_V0.9081.00
113_F117_L0.9041.00
56_G60_K0.9031.00
4_L22_A0.9001.00
180_T217_T0.8991.00
88_L91_S0.8981.00
176_D223_T0.8961.00
211_P214_G0.8961.00
120_L123_D0.8941.00
60_K66_D0.8931.00
72_L100_L0.8881.00
122_L125_S0.8881.00
139_G150_T0.8791.00
151_D165_S0.8621.00
53_V58_L0.8621.00
2_G23_N0.8601.00
31_G48_L0.8601.00
76_L80_G0.8591.00
95_T140_D0.8491.00
96_G100_L0.8471.00
20_L31_G0.8361.00
125_S128_F0.8341.00
163_T182_T0.8331.00
123_D126_D0.8311.00
225_T228_D0.8301.00
85_V89_L0.8291.00
73_S101_R0.8281.00
168_V226_W0.8271.00
89_L173_E0.8201.00
160_A164_G0.8121.00
126_D129_G0.8091.00
138_S152_D0.8061.00
167_T174_T0.8051.00
19_P22_A0.8041.00
60_K63_G0.8041.00
96_G148_A0.8031.00
41_G81_P0.7981.00
29_L33_G0.7951.00
6_G17_L0.7931.00
124_F128_F0.7921.00
73_S99_S0.7861.00
190_A194_A0.7851.00
165_S180_T0.7821.00
124_F127_L0.7811.00
93_N145_N0.7801.00
6_G10_L0.7801.00
137_L155_L0.7781.00
27_G53_V0.7781.00
89_L171_D0.7771.00
144_K147_V0.7751.00
33_G46_L0.7731.00
208_L211_P0.7701.00
54_D69_S0.7671.00
52_G73_S0.7661.00
71_K101_R0.7541.00
82_G86_A0.7541.00
155_L162_V0.7531.00
72_L76_L0.7521.00
207_L212_L0.7511.00
52_G101_R0.7491.00
121_A127_L0.7411.00
120_L125_S0.7401.00
64_G67_N0.7401.00
45_S48_L0.7371.00
55_L100_L0.7371.00
17_L33_G0.7291.00
143_I170_L0.7281.00
8_L15_L0.7251.00
191_L194_A0.7251.00
102_D133_A0.7251.00
35_L44_F0.7221.00
11_K16_R0.7211.00
76_L96_G0.7201.00
89_L92_L0.7191.00
211_P215_L0.7181.00
111_L116_G0.7181.00
126_D130_K0.7141.00
146_G170_L0.7131.00
152_D163_T0.7131.00
57_A61_A0.7101.00
190_A193_G0.7051.00
188_S191_L0.7031.00
29_L48_L0.6991.00
55_L72_L0.6931.00
209_G212_L0.6911.00
189_G192_G0.6901.00
132_T157_G0.6861.00
206_K212_L0.6771.00
86_A89_L0.6751.00
123_D128_F0.6731.00
146_G171_D0.6711.00
82_G85_V0.6711.00
210_K213_G0.6691.00
168_V173_E0.6671.00
212_L216_L0.6631.00
111_L115_L0.6631.00
113_F118_L0.6621.00
56_G66_D0.6601.00
78_L94_G0.6571.00
123_D127_L0.6571.00
175_L226_W0.6551.00
133_A158_P0.6541.00
148_A170_L0.6541.00
58_L62_L0.6541.00
92_L143_I0.6531.00
83_A86_A0.6521.00
163_T180_T0.6501.00
26_G71_K0.6471.00
113_F119_S0.6471.00
134_F157_G0.6461.00
148_A168_V0.6411.00
207_L216_L0.6371.00
212_L215_L0.6361.00
123_D129_G0.6361.00
120_L129_G0.6341.00
210_K214_G0.6331.00
49_K73_S0.6321.00
121_A125_S0.6311.00
137_L153_L0.6291.00
124_F129_G0.6291.00
164_G177_L0.6291.00
29_L50_L0.6291.00
82_G87_P0.6271.00
13_G36_D0.6211.00
61_A65_A0.6201.00
136_D154_V0.6181.00
129_G132_T0.6151.00
25_Y57_A0.6131.00
60_K65_A0.6071.00
59_L63_G0.6071.00
168_V175_L0.6071.00
51_D75_D0.6031.00
19_P32_S0.6021.00
160_A181_V0.6001.00
206_K211_P0.5991.00
102_D135_D0.5991.00
159_A187_L0.5901.00
16_R19_P0.5891.00
81_P84_S0.5881.00
82_G88_L0.5881.00
159_A184_P0.5871.00
39_G42_P0.5831.00
179_L220_Y0.5831.00
13_G37_A0.5801.00
188_S193_G0.5771.00
74_L78_L0.5751.00
87_P91_S0.5741.00
121_A129_G0.5701.00
27_G50_L0.5681.00
58_L72_L0.5671.00
213_G216_L0.5661.00
169_D173_E0.5641.00
122_L126_D0.5601.00
25_Y58_L0.5561.00
42_P46_L0.5551.00
28_T52_G0.5541.00
100_L137_L0.5531.00
217_T220_Y0.5471.00
185_A188_S0.5461.00
124_F130_K0.5451.00
187_L190_A0.5441.00
138_S154_V0.5421.00
52_G72_L0.5391.00
226_W229_P0.5391.00
140_D150_T0.5361.00
78_L92_L0.5341.00
156_D184_P0.5321.00
147_V171_D0.5301.00
184_P188_S0.5301.00
209_G215_L0.5281.00
70_G100_L0.5261.00
31_G35_L0.5261.00
90_A146_G0.5251.00
161_R184_P0.5251.00
109_N114_D0.5251.00
52_G58_L0.5241.00
150_T164_G0.5231.00
63_G66_D0.5221.00
209_G213_G0.5211.00
69_S131_G0.5191.00
188_S192_G0.5141.00
132_T160_A0.5131.00
150_T168_V0.5111.00
215_L220_Y0.5101.00
46_L94_G0.5091.00
94_G98_L0.5041.00
125_S129_G0.5041.00
189_G194_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yguA 3 0.4739 8.5 0.915 Contact Map
3rwxA 1 0.7435 7.2 0.918 Contact Map
3jx8A 4 0.4913 5.4 0.923 Contact Map
4opwA 1 0.4913 5.2 0.923 Contact Map
3lycA 2 0.4957 3.9 0.927 Contact Map
3petA 2 0.487 3.7 0.928 Contact Map
3j9qA 8 0.2696 2.6 0.934 Contact Map
4ojdH 3 0.4304 2.2 0.936 Contact Map
3butA 2 0.3913 2.1 0.937 Contact Map
1r6vA 1 0.3522 2 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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