GREMLIN Database
FtsK_4TM - 4TM region of DNA translocase FtsK/SpoIIIE
PFAM: PF13491 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 171 (163)
Sequences: 29108 (20931)
Seq/√Len: 1639.4
META: 0.923

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_F47_L5.0971.00
25_S46_W4.3791.00
58_L66_A2.9061.00
22_A47_L2.4861.00
27_S44_H2.4321.00
16_A74_L2.3331.00
13_L77_G2.2811.00
19_L54_L2.2641.00
65_A103_L2.2271.00
56_D60_Q2.2181.00
19_L58_L2.1821.00
14_A149_A2.0931.00
108_A131_A2.0231.00
128_D132_G1.9641.00
16_A73_L1.9591.00
16_A70_P1.9561.00
16_A77_G1.9161.00
24_A67_F1.8951.00
105_A147_L1.8601.00
138_L146_L1.7461.00
9_G77_G1.7411.00
78_W82_R1.6981.00
156_I163_W1.6561.00
109_L131_A1.6361.00
21_L47_L1.5711.00
32_S56_D1.5311.00
49_R53_W1.5261.00
34_S56_D1.5251.00
59_L67_F1.5241.00
155_L159_T1.5121.00
23_L67_F1.5121.00
129_L133_L1.4931.00
141_T144_T1.4901.00
26_Y55_A1.4831.00
23_L58_L1.4741.00
28_P31_P1.4641.00
20_L67_F1.4581.00
9_G81_L1.4441.00
20_L70_P1.4441.00
25_S45_N1.4411.00
135_A140_F1.4261.00
30_D52_A1.4231.00
68_L103_L1.3891.00
134_L147_L1.3751.00
95_G154_G1.3751.00
101_L104_S1.3751.00
21_L46_W1.3681.00
3_R6_E1.3561.00
20_L24_A1.3541.00
154_G158_A1.3271.00
131_A135_A1.2721.00
54_L58_L1.2651.00
110_L144_T1.2381.00
57_L61_L1.2191.00
13_L17_L1.2041.00
102_S154_G1.2001.00
90_L93_L1.1691.00
95_G99_L1.1601.00
43_V49_R1.1511.00
72_L96_F1.1351.00
105_A130_L1.1321.00
100_L104_S1.1271.00
134_L143_A1.1171.00
132_G136_S1.1171.00
75_V79_R1.1161.00
99_L103_L1.1161.00
90_L94_L1.1121.00
102_S151_L1.1061.00
94_L97_L1.1011.00
50_V53_W1.0821.00
18_F22_A1.0671.00
118_L121_G1.0621.00
35_T38_S1.0581.00
53_W56_D1.0551.00
91_L95_G1.0531.00
9_G13_L1.0511.00
16_A20_L1.0481.00
4_L7_I1.0371.00
66_A69_L1.0331.00
100_L103_L1.0301.00
129_L132_G1.0201.00
76_W93_L1.0121.00
9_G12_L1.0061.00
132_G135_A0.9941.00
28_P32_S0.9891.00
103_L151_L0.9871.00
41_A44_H0.9851.00
102_S106_L0.9841.00
31_P56_D0.9761.00
77_G81_L0.9731.00
133_L137_L0.9631.00
140_F144_T0.9551.00
38_S41_A0.9501.00
131_A143_A0.9461.00
96_F100_L0.9411.00
153_V157_L0.9391.00
6_E83_R0.9391.00
121_G128_D0.9371.00
47_L50_V0.9351.00
154_G157_L0.9061.00
23_L66_A0.9051.00
23_L59_L0.9041.00
62_F69_L0.8991.00
30_D43_V0.8961.00
30_D45_N0.8911.00
65_A104_S0.8871.00
60_Q125_V0.8761.00
29_A44_H0.8761.00
39_G42_P0.8741.00
103_L106_L0.8611.00
32_S53_W0.8561.00
19_L23_L0.8561.00
5_R83_R0.8551.00
139_G142_G0.8501.00
89_L93_L0.8301.00
50_V137_L0.8291.00
88_R92_R0.8281.00
144_T148_L0.8271.00
10_L14_A0.8241.00
133_L136_S0.8231.00
102_S105_A0.8221.00
152_L156_I0.8221.00
92_R95_G0.8221.00
126_L129_L0.8191.00
148_L152_L0.8191.00
66_A70_P0.8171.00
33_W57_L0.8131.00
34_S37_G0.8031.00
65_A107_L0.8031.00
88_R91_L0.7921.00
61_L125_V0.7881.00
21_L141_T0.7861.00
130_L133_L0.7811.00
43_V46_W0.7791.00
12_L73_L0.7731.00
65_A68_L0.7671.00
113_S116_W0.7661.00
160_G163_W0.7661.00
112_P115_G0.7661.00
64_L116_W0.7641.00
68_L99_L0.7641.00
34_S60_Q0.7611.00
136_S140_F0.7561.00
159_T163_W0.7541.00
25_S30_D0.7531.00
142_G145_L0.7481.00
12_L80_L0.7471.00
79_R84_R0.7461.00
155_L161_F0.7431.00
89_L92_R0.7401.00
104_S107_L0.7311.00
77_G80_L0.7301.00
110_L113_S0.7291.00
125_V129_L0.7281.00
95_G102_S0.7271.00
95_G157_L0.7181.00
104_S108_A0.7151.00
98_L154_G0.7151.00
102_S150_L0.7121.00
156_I159_T0.7111.00
33_W53_W0.7101.00
101_L105_A0.7091.00
70_P74_L0.7061.00
57_L60_Q0.7051.00
73_L76_W0.7031.00
49_R136_S0.7021.00
64_L107_L0.6981.00
7_I153_V0.6971.00
8_L12_L0.6961.00
92_R96_F0.6931.00
13_L16_A0.6931.00
92_R99_L0.6881.00
48_G51_G0.6871.00
50_V138_L0.6851.00
45_N52_A0.6841.00
117_G120_F0.6821.00
12_L77_G0.6811.00
33_W56_D0.6811.00
149_A153_V0.6771.00
37_G41_A0.6711.00
95_G98_L0.6701.00
45_N51_G0.6651.00
5_R80_L0.6621.00
53_W57_L0.6561.00
80_L83_R0.6531.00
36_A39_G0.6491.00
94_L98_L0.6461.00
14_A18_F0.6411.00
95_G100_L0.6411.00
50_V54_L0.6391.00
96_F99_L0.6391.00
98_L102_S0.6361.00
162_S165_R0.6341.00
62_F100_L0.6271.00
9_G16_A0.6201.00
29_A32_S0.6201.00
87_R92_R0.6201.00
135_A143_A0.6191.00
8_L11_L0.6171.00
107_L123_G0.6111.00
99_L154_G0.6071.00
97_L101_L0.5981.00
144_T147_L0.5961.00
43_V52_A0.5951.00
3_R9_G0.5941.00
161_F165_R0.5871.00
93_L97_L0.5791.00
31_P55_A0.5791.00
134_L138_L0.5781.00
79_R83_R0.5771.00
105_A108_A0.5741.00
102_S108_A0.5741.00
151_L155_L0.5731.00
27_S30_D0.5661.00
135_A139_G0.5621.00
8_L80_L0.5591.00
70_P73_L0.5591.00
126_L130_L0.5531.00
150_L154_G0.5461.00
37_G40_D0.5421.00
147_L151_L0.5411.00
111_F114_L0.5381.00
91_L94_L0.5371.00
145_L148_L0.5351.00
4_L8_L0.5331.00
158_A161_F0.5301.00
108_A123_G0.5291.00
19_L70_P0.5261.00
143_A147_L0.5251.00
68_L71_L0.5221.00
94_L99_L0.5211.00
156_I161_F0.5211.00
32_S60_Q0.5191.00
101_L126_L0.5181.00
13_L74_L0.5161.00
90_L101_L0.5111.00
90_L97_L0.5091.00
108_A112_P0.5091.00
49_R137_L0.5091.00
19_L73_L0.5061.00
107_L110_L0.5061.00
141_T145_L0.5021.00
99_L102_S0.5001.00
107_L111_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2q67A 3 0.4327 3.9 0.931 Contact Map
2h88D 1 0.2515 3.2 0.934 Contact Map
2k1eA 3 0.5965 2.6 0.937 Contact Map
3x29A 1 0.386 2.2 0.939 Contact Map
4p79A 1 0.4211 2 0.941 Contact Map
4xk8L 1 0.3567 1.9 0.941 Contact Map
3dinE 1 0.3801 1.9 0.942 Contact Map
3wdoA 1 0.9942 1.9 0.942 Contact Map
2acmA 1 0.1696 1.8 0.943 Contact Map
2mn6B 2 0.193 1.7 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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