GREMLIN Database
DUF4115 - Domain of unknown function (DUF4115)
PFAM: PF13464 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 74 (71)
Sequences: 31292 (21121)
Seq/√Len: 2506.6
META: 0.93

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_T51_E2.3961.00
5_A26_L2.3511.00
8_D27_K2.2621.00
12_E23_E2.1051.00
4_R31_T2.0581.00
51_E58_P2.0411.00
2_V53_T1.9081.00
20_V23_E1.8301.00
7_E49_A1.8121.00
27_K30_E1.7821.00
53_T58_P1.7781.00
2_V31_T1.7261.00
10_W45_G1.7151.00
44_L50_V1.6791.00
24_G32_R1.6401.00
2_V33_T1.6381.00
22_F26_L1.6221.00
46_N49_A1.5981.00
4_R51_E1.5481.00
36_A40_L1.5371.00
5_A11_V1.5331.00
12_E20_V1.4671.00
14_T41_R1.4401.00
7_E46_N1.4111.00
8_D25_L1.3931.00
43_R71_R1.3761.00
22_F32_R1.3331.00
4_R53_T1.3281.00
65_A68_Q1.3001.00
14_T20_V1.2981.00
26_L32_R1.2931.00
9_S44_L1.2851.00
52_V59_V1.2681.00
12_E43_R1.1281.00
3_L34_V1.0981.00
13_V34_V1.0741.00
26_L30_E1.0591.00
15_D19_K1.0191.00
5_A50_V1.0071.00
3_L52_V0.9941.00
9_S50_V0.9861.00
22_F34_V0.9771.00
16_A21_L0.9421.00
43_R69_V0.9301.00
7_E28_A0.9051.00
8_D28_A0.8841.00
24_G30_E0.8561.00
7_E66_R0.8421.00
53_T56_G0.8211.00
9_S49_A0.8191.00
11_V26_L0.8001.00
68_Q71_R0.7951.00
6_T49_A0.7931.00
48_G68_Q0.7911.00
41_R71_R0.7861.00
11_V44_L0.7771.00
17_D37_A0.7661.00
13_V40_L0.7481.00
13_V42_L0.7431.00
21_L24_G0.7201.00
25_L45_G0.7051.00
48_G63_G0.6951.00
44_L62_L0.6901.00
65_A70_A0.6841.00
65_A69_V0.6811.00
5_A9_S0.6721.00
60_G63_G0.6701.00
54_V59_V0.6621.00
67_G70_A0.6621.00
10_W25_L0.6591.00
47_A69_V0.6571.00
35_E40_L0.6551.00
16_A36_A0.6471.00
3_L11_V0.6431.00
66_R70_A0.6291.00
23_E43_R0.6251.00
62_L72_L0.6251.00
69_V72_L0.6201.00
36_A54_V0.6091.00
3_L50_V0.6041.00
10_W23_E0.6031.00
14_T43_R0.6021.00
9_S45_G0.6001.00
40_L54_V0.5911.00
28_A49_A0.5911.00
35_E55_N0.5871.00
13_V36_A0.5851.00
58_P61_L0.5811.00
16_A34_V0.5551.00
47_A50_V0.5421.00
42_L72_L0.5421.00
45_G69_V0.5311.00
18_G39_P0.5301.00
37_A40_L0.5291.00
15_D18_G0.5291.00
36_A39_P0.5201.00
9_S47_A0.5191.00
52_V62_L0.5131.00
18_G38_E0.5121.00
63_G68_Q0.5111.00
47_A62_L0.5111.00
3_L13_V0.5061.00
34_V38_E0.5041.00
34_V40_L0.5031.00
1_L40_L0.5011.00
18_G41_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ogoX 1 0.9865 36.9 0.793 Contact Map
1x0cA 2 0.973 34 0.797 Contact Map
3ujzA 2 0.3649 14.7 0.828 Contact Map
1fxzA 3 1 14.2 0.83 Contact Map
3c3vA 5 1 14.1 0.83 Contact Map
4wqoA 1 0.9595 13.6 0.832 Contact Map
3kglA 3 1 12.3 0.835 Contact Map
3fipA 1 0.7973 12.3 0.835 Contact Map
3fz3A 5 1 11.6 0.836 Contact Map
3qacA 3 1 11.1 0.838 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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