GREMLIN Database
MUG113 - Meiotically up-regulated gene 113
PFAM: PF13455 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 83 (69)
Sequences: 19737 (14084)
Seq/√Len: 1695.5
META: 0.92

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_M39_P4.7341.00
5_M38_A3.0921.00
52_K75_E2.1181.00
45_L49_F2.0371.00
46_H69_F1.8531.00
71_V76_I1.7561.00
54_V70_R1.7281.00
8_D11_D1.6281.00
16_L19_A1.6021.00
39_P43_K1.5741.00
37_D40_K1.5701.00
1_Y76_I1.5231.00
72_S75_E1.4951.00
40_K44_L1.4911.00
43_K47_R1.4761.00
71_V75_E1.4081.00
1_Y73_L1.4071.00
49_F71_V1.3371.00
9_P29_T1.3191.00
17_Q20_S1.3071.00
6_T9_P1.3001.00
44_L48_R1.2751.00
3_I49_F1.2681.00
9_P13_I1.2551.00
26_V29_T1.2461.00
12_R67_E1.2421.00
17_Q23_P1.2101.00
11_D15_E1.2081.00
50_A53_R1.2061.00
53_R56_G1.2031.00
13_I17_Q1.1941.00
7_R38_A1.1761.00
32_T41_L1.1461.00
38_A41_L1.1411.00
73_L77_K1.1391.00
13_I16_L1.0901.00
49_F79_A1.0761.00
10_E14_K1.0741.00
25_E28_A1.0711.00
28_A77_K1.0691.00
47_R50_A1.0411.00
48_R79_A1.0361.00
17_Q55_N1.0341.00
1_Y71_V1.0231.00
15_E19_A0.9271.00
41_L45_L0.9161.00
11_D14_K0.8961.00
52_K71_V0.8631.00
30_I33_D0.8341.00
75_E78_E0.8231.00
55_N58_R0.8161.00
13_I26_V0.8151.00
24_F68_W0.8061.00
41_L44_L0.7911.00
20_S24_F0.7901.00
45_L79_A0.7841.00
74_E78_E0.7821.00
45_L80_I0.7791.00
10_E26_V0.7631.00
22_F25_E0.7541.00
33_D37_D0.7461.00
14_K18_T0.7351.00
10_E13_I0.7341.00
29_T32_T0.7171.00
13_I19_A0.7091.00
16_L20_S0.7061.00
16_L24_F0.7021.00
21_P24_F0.6971.00
32_T38_A0.6901.00
45_L76_I0.6841.00
24_F33_D0.6701.00
10_E29_T0.6661.00
48_R52_K0.6661.00
44_L47_R0.6631.00
24_F27_V0.6531.00
2_K67_E0.6501.00
26_V32_T0.6331.00
49_F76_I0.6291.00
27_V73_L0.6261.00
50_A56_G0.6261.00
43_K46_H0.6231.00
17_Q68_W0.6191.00
3_I46_H0.6121.00
75_E79_A0.5871.00
15_E18_T0.5771.00
14_K17_Q0.5671.00
5_M43_K0.5651.00
52_K72_S0.5501.00
28_A31_E0.5481.00
25_E32_T0.5391.00
71_V79_A0.5391.00
5_M37_D0.5381.00
24_F28_A0.5381.00
25_E29_T0.5351.00
16_L46_H0.5351.00
3_I69_F0.5321.00
16_L68_W0.5211.00
3_I45_L0.5201.00
12_R42_E0.5101.00
21_P68_W0.5091.00
42_E46_H0.5091.00
45_L48_R0.5061.00
21_P25_E0.5031.00
24_F32_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xlgA 1 0.7952 71 0.77 Contact Map
1zg2A 1 0.8795 68.7 0.774 Contact Map
1ywlA 1 0.8072 61.6 0.784 Contact Map
1yd0A 1 0.6627 13.4 0.849 Contact Map
1yd6A 5 0.7349 11.1 0.855 Contact Map
1mk0A 1 0.7349 9.7 0.858 Contact Map
1kcmA 2 0.9518 9.7 0.858 Contact Map
1f6kA 3 0.7952 6.9 0.867 Contact Map
4n4pA 3 0.8313 6.1 0.871 Contact Map
2zxqA 1 0.8795 5.2 0.874 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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