GREMLIN Database
DUF4112 - Domain of unknown function (DUF4112)
PFAM: PF13430 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 105 (101)
Sequences: 9337 (5443)
Seq/√Len: 541.5
META: 0.891

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_E102_E3.5811.00
14_S95_R3.2871.00
63_V100_L3.0641.00
32_G85_D2.6371.00
29_A89_F2.3421.00
43_A75_T2.2771.00
55_R64_L2.0841.00
40_L75_T2.0371.00
74_D88_D1.9941.00
11_L27_L1.9111.00
60_P104_H1.8781.00
86_L90_A1.8671.00
46_S71_V1.8571.00
5_L98_L1.8161.00
4_R52_E1.7841.00
23_I89_F1.7811.00
12_L45_L1.7411.00
63_V104_H1.7411.00
10_R15_A1.6741.00
17_R22_G1.6641.00
17_R24_R1.6311.00
50_V71_V1.6111.00
75_T79_A1.5231.00
47_L51_W1.4991.00
50_V68_L1.4611.00
48_Y52_E1.4331.00
50_V64_L1.3531.00
10_R14_S1.3501.00
77_V87_F1.3431.00
59_V63_V1.3391.00
18_I21_T1.3231.00
53_A101_L1.3151.00
59_V101_L1.2691.00
70_N100_L1.2591.00
60_P63_V1.2321.00
31_I42_G1.2151.00
7_R10_R1.2031.00
8_L45_L1.1641.00
42_G74_D1.1361.00
11_L15_A1.1351.00
28_D42_G1.1271.00
14_S24_R1.1231.00
70_N91_F1.1161.00
65_A69_G1.1111.00
52_E57_L1.0801.00
51_W55_R1.0781.00
34_I37_V1.0711.00
62_V66_R1.0661.00
5_L52_E1.0541.00
70_N97_N1.0501.00
51_W56_R1.0301.00
52_E56_R1.0271.00
39_D78_G1.0241.00
74_D93_A1.0081.00
5_L101_L0.9741.00
72_A76_L0.9441.00
21_T24_R0.9311.00
16_F25_F0.9131.00
95_R99_A0.9101.00
43_A47_L0.9051.00
64_L68_L0.8771.00
9_A98_L0.8731.00
4_R48_Y0.8721.00
28_D32_G0.8601.00
67_M97_N0.8531.00
98_L102_E0.8421.00
28_D74_D0.8391.00
40_L43_A0.8331.00
3_R7_R0.8301.00
32_G39_D0.8051.00
41_A45_L0.8041.00
14_S92_K0.7971.00
9_A13_D0.7951.00
40_L44_L0.7891.00
87_F91_F0.7861.00
66_R70_N0.7761.00
62_V65_A0.7751.00
49_I98_L0.7741.00
3_R6_E0.7701.00
69_G73_I0.7681.00
61_R65_A0.7631.00
15_A25_F0.7631.00
55_R58_G0.7541.00
39_D85_D0.7521.00
46_S74_D0.7521.00
57_L101_L0.7471.00
99_A103_R0.7421.00
79_A82_V0.7371.00
77_V80_V0.7341.00
28_D88_D0.7261.00
17_R23_I0.7231.00
5_L49_I0.7221.00
46_S94_N0.7221.00
73_I77_V0.7221.00
68_L72_A0.7201.00
99_A102_E0.7181.00
88_D93_A0.7171.00
42_G45_L0.7161.00
83_V90_A0.7111.00
82_V85_D0.7091.00
25_F89_F0.7081.00
53_A57_L0.7071.00
8_L48_Y0.7031.00
91_F96_R0.6951.00
62_V69_G0.6931.00
33_L85_D0.6801.00
49_I53_A0.6781.00
4_R7_R0.6691.00
17_R20_G0.6691.00
9_A95_R0.6661.00
36_G39_D0.6531.00
101_L104_H0.6451.00
43_A71_V0.6441.00
80_V83_V0.6321.00
87_F90_A0.6271.00
73_I76_L0.6271.00
16_F30_I0.6161.00
49_I94_N0.6161.00
76_L79_A0.6101.00
65_A68_L0.6021.00
49_I52_E0.6001.00
67_M101_L0.5991.00
10_R95_R0.5951.00
31_I85_D0.5901.00
47_L68_L0.5881.00
9_A14_S0.5860.99
91_F94_N0.5860.99
6_E98_L0.5770.99
46_S93_A0.5720.99
72_A75_T0.5710.99
23_I90_A0.5680.99
74_D90_A0.5680.99
78_G85_D0.5620.99
16_F27_L0.5590.99
18_I23_I0.5530.99
27_L30_I0.5440.99
19_P22_G0.5420.99
37_V41_A0.5400.99
88_D91_F0.5390.99
59_V104_H0.5380.99
73_I87_F0.5270.99
69_G96_R0.5240.99
11_L14_S0.5210.99
50_V67_M0.5170.99
79_A87_F0.5160.99
79_A83_V0.5130.99
70_N96_R0.5120.99
25_F29_A0.5110.99
41_A44_L0.5070.99
17_R21_T0.5040.98
10_R17_R0.5030.98
61_R64_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c9kA 1 0.4857 5 0.927 Contact Map
2e55A 3 0.4762 4.7 0.928 Contact Map
2e1dA 2 0.8095 4.7 0.928 Contact Map
1f0lA 1 0.8381 4.2 0.93 Contact Map
3tx3A 2 1 3.9 0.931 Contact Map
3eb7A 2 0.4095 3.8 0.931 Contact Map
1dlcA 1 0.419 3.4 0.933 Contact Map
3racA 2 0.3238 3.3 0.933 Contact Map
1ciyA 1 0.4095 3.1 0.934 Contact Map
1pixA 4 0.3524 3.1 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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