GREMLIN Database
HNH_2 - HNH endonuclease
PFAM: PF13391 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 66 (52)
Sequences: 17208 (9370)
Seq/√Len: 1299.4
META: 0.87

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_E56_A3.2871.00
13_E55_H2.9451.00
4_T51_C2.4911.00
13_E52_P2.3511.00
52_P56_A2.3151.00
4_T54_H2.2501.00
14_A47_G2.2471.00
51_C54_H1.9701.00
26_W29_E1.7051.00
15_A59_D1.6581.00
15_A55_H1.4491.00
29_E40_E1.3661.00
56_A60_R1.3261.00
12_L49_L1.2901.00
3_V54_H1.2691.00
11_L56_A1.2321.00
2_A48_L1.2041.00
40_E43_D1.1601.00
55_H59_D1.0771.00
27_R30_G1.0531.00
26_W30_G1.0321.00
10_E60_R1.0151.00
54_H57_L0.9771.00
11_L57_L0.9651.00
26_W42_L0.9631.00
11_L52_P0.9541.00
3_V63_I0.9481.00
17_I58_F0.9471.00
18_K41_R0.9401.00
18_K40_E0.9111.00
44_P49_L0.8971.00
11_L62_L0.8971.00
14_A49_L0.8871.00
59_D65_I0.8821.00
15_A50_L0.8521.00
30_G41_R0.8521.00
18_K29_E0.8491.00
3_V50_L0.8471.00
61_G64_S0.8371.00
30_G40_E0.8251.00
54_H63_I0.8181.00
2_A49_L0.8111.00
3_V65_I0.8031.00
17_I48_L0.7511.00
17_I46_N0.7491.00
15_A49_L0.7311.00
42_L47_G0.7191.00
19_P59_D0.7071.00
30_G39_E0.7011.00
11_L53_N0.6931.00
18_K30_G0.6861.00
44_P47_G0.6861.00
19_P28_D0.6791.00
6_L51_C0.6631.00
15_A48_L0.6581.00
8_I11_L0.6531.00
29_E39_E0.6381.00
6_L9_P0.6381.00
16_H59_D0.6351.00
18_K61_G0.6241.00
10_E62_L0.6121.00
26_W41_R0.6101.00
17_I45_R0.6051.00
15_A58_F0.6051.00
2_A50_L0.5981.00
48_L65_I0.5941.00
2_A54_H0.5941.00
6_L53_N0.5581.00
61_G65_I0.5521.00
48_L58_F0.5431.00
59_D66_D0.5381.00
3_V58_F0.5321.00
18_K64_S0.5291.00
8_I62_L0.5281.00
58_F61_G0.5231.00
50_L63_I0.5121.00
58_F63_I0.5011.00
57_L62_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ogeA 1 0.7273 92.5 0.663 Contact Map
4h9dA 3 0.7576 91 0.677 Contact Map
4un4B 1 0.7424 90.5 0.68 Contact Map
3m7kA 2 0.9091 56.7 0.766 Contact Map
3g27A 2 0.6364 18.2 0.821 Contact Map
4uhqA 1 0.7576 5.2 0.86 Contact Map
7ceiB 1 0.6667 4.8 0.863 Contact Map
3plwA 1 0.7576 3.4 0.872 Contact Map
2jsoA 1 0.5152 3.4 0.873 Contact Map
3zjeA 2 0.6818 3.4 0.873 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0039 seconds.