GREMLIN Database
ABC2_membrane_5 - ABC-2 family transporter protein
PFAM: PF13346 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 206 (183)
Sequences: 11020 (9359)
Seq/√Len: 691.9
META: 0.81

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_S77_Q4.3751.00
80_L198_Y3.5201.00
86_A131_L3.1391.00
64_T68_L2.9391.00
195_A199_F2.9221.00
69_L75_R2.7161.00
190_F194_L2.4221.00
163_A166_S2.2361.00
163_A167_L2.1991.00
90_L127_G2.1861.00
45_L48_A2.1651.00
112_D115_P2.0831.00
175_I178_R1.9481.00
143_N147_A1.9341.00
162_F166_S1.8981.00
44_L48_A1.7901.00
77_Q80_L1.7831.00
151_F155_F1.7791.00
177_L180_L1.7711.00
41_S44_L1.7381.00
59_E64_T1.7371.00
28_F31_F1.7101.00
137_L141_F1.6921.00
104_L108_L1.6881.00
105_L109_G1.6801.00
68_L78_I1.6801.00
144_Q147_A1.6571.00
105_L108_L1.6411.00
55_L82_K1.6231.00
81_G85_A1.6031.00
79_V139_F1.5881.00
194_L198_Y1.5861.00
87_L128_L1.5761.00
63_G66_E1.5681.00
77_Q81_G1.5551.00
143_N146_G1.5511.00
49_A52_T1.5481.00
125_L128_L1.5421.00
186_L190_F1.5291.00
24_L27_L1.5261.00
45_L49_A1.4621.00
36_F39_F1.3971.00
48_A52_T1.3891.00
160_L163_A1.3861.00
91_L124_L1.3811.00
148_I152_I1.3811.00
29_F32_L1.3701.00
54_R58_E1.3441.00
154_I158_F1.3391.00
176_D179_D1.3381.00
162_F165_F1.3271.00
59_E82_K1.3221.00
23_L26_I1.3201.00
55_L86_A1.3121.00
182_L185_S1.2991.00
58_E61_K1.2721.00
80_L84_L1.2561.00
41_S48_A1.2511.00
76_K80_L1.2501.00
68_L82_K1.2491.00
25_A30_L1.2491.00
134_G138_S1.2411.00
40_F44_L1.2351.00
25_A29_F1.2261.00
64_T67_L1.2251.00
66_E69_L1.2091.00
33_N36_F1.2071.00
28_F32_L1.1871.00
176_D180_L1.1651.00
104_L107_L1.1611.00
183_F187_I1.1431.00
136_P139_F1.1421.00
174_L177_L1.1371.00
150_L153_V1.1311.00
172_L175_I1.1271.00
40_F43_L1.1251.00
44_L50_I1.1251.00
174_L180_L1.1151.00
173_G180_L1.1111.00
188_V192_L1.1051.00
26_I31_F1.1011.00
107_L110_P1.0951.00
71_L75_R1.0831.00
44_L49_A1.0781.00
150_L154_I1.0651.00
67_L71_L1.0601.00
183_F186_L1.0521.00
44_L47_L1.0411.00
172_L178_R1.0381.00
78_I139_F1.0341.00
69_L78_I1.0151.00
171_S174_L1.0131.00
83_Y197_S1.0041.00
115_P119_G1.0031.00
26_I29_F1.0021.00
46_F49_A0.9901.00
175_I179_D0.9811.00
41_S50_I0.9811.00
160_L166_S0.9781.00
173_G176_D0.9771.00
117_L120_Y0.9701.00
34_S37_S0.9661.00
173_G177_L0.9651.00
136_P197_S0.9641.00
136_P140_K0.9631.00
149_I153_V0.9631.00
185_S189_I0.9621.00
180_L183_F0.9591.00
192_L196_L0.9581.00
116_L119_G0.9581.00
174_L178_R0.9561.00
194_L197_S0.9551.00
54_R57_A0.9531.00
48_A51_L0.9521.00
102_L105_L0.9441.00
127_G131_L0.9431.00
181_I185_S0.9241.00
22_L26_I0.9231.00
22_L25_A0.9191.00
196_L200_L0.9101.00
35_S38_L0.8961.00
183_F190_F0.8931.00
21_L26_I0.8911.00
19_L23_L0.8871.00
17_L21_L0.8861.00
155_F158_F0.8611.00
187_I190_F0.8591.00
83_Y136_P0.8521.00
189_I193_L0.8501.00
47_L50_I0.8461.00
190_F193_L0.8441.00
162_F167_L0.8391.00
116_L120_Y0.8381.00
173_G178_R0.8331.00
122_G125_L0.8311.00
160_L165_F0.8291.00
130_F134_G0.8261.00
60_E142_G0.8261.00
37_S40_F0.8221.00
114_G118_G0.8091.00
38_L42_L0.8091.00
179_D183_F0.8051.00
27_L30_L0.8041.00
23_L28_F0.8011.00
25_A28_F0.8001.00
27_L31_F0.8001.00
65_D78_I0.7981.00
152_I158_F0.7961.00
45_L50_I0.7951.00
151_F159_F0.7911.00
126_L130_F0.7851.00
90_L94_L0.7851.00
173_G182_L0.7831.00
21_L25_A0.7681.00
158_F162_F0.7621.00
33_N37_S0.7611.00
82_K139_F0.7601.00
172_L177_L0.7591.00
21_L30_L0.7561.00
42_L50_I0.7551.00
22_L29_F0.7521.00
40_F48_A0.7481.00
36_F40_F0.7461.00
141_F146_G0.7421.00
159_F162_F0.7291.00
160_L164_L0.7251.00
190_F197_S0.7251.00
24_L31_F0.7251.00
172_L176_D0.7201.00
134_G137_L0.7151.00
83_Y87_L0.7141.00
56_F60_E0.7131.00
124_L128_L0.7091.00
142_G147_A0.7081.00
171_S178_R0.7071.00
135_L138_S0.7051.00
182_L186_L0.7031.00
169_S179_D0.7021.00
145_K148_I0.7021.00
192_L195_A0.6991.00
161_L165_F0.6921.00
35_S39_F0.6891.00
24_L30_L0.6891.00
161_L166_S0.6861.00
56_F71_L0.6841.00
104_L109_G0.6831.00
18_L22_L0.6811.00
180_L184_L0.6801.00
186_L189_I0.6791.00
73_V78_I0.6781.00
62_S65_D0.6771.00
149_I156_L0.6721.00
21_L28_F0.6721.00
64_T78_I0.6691.00
42_L45_L0.6691.00
84_L88_L0.6661.00
131_L134_G0.6651.00
41_S47_L0.6651.00
17_L22_L0.6641.00
118_G122_G0.6631.00
177_L181_I0.6621.00
56_F79_V0.6621.00
175_I180_L0.6611.00
18_L21_L0.6601.00
59_E68_L0.6591.00
39_F46_F0.6581.00
171_S175_I0.6571.00
157_L160_L0.6561.00
174_L179_D0.6561.00
132_A136_P0.6531.00
26_I32_L0.6481.00
142_G146_G0.6461.00
151_F156_L0.6441.00
185_S188_V0.6411.00
139_F143_N0.6411.00
96_L100_Y0.6401.00
21_L31_F0.6381.00
126_L129_L0.6381.00
160_L167_L0.6371.00
184_L187_I0.6351.00
42_L46_F0.6331.00
47_L52_T0.6321.00
171_S176_D0.6271.00
42_L49_A0.6271.00
21_L32_L0.6261.00
27_L32_L0.6251.00
191_L194_L0.6241.00
83_Y132_A0.6241.00
22_L28_F0.6231.00
41_S49_A0.6211.00
95_L99_L0.6151.00
128_L132_A0.6151.00
132_A194_L0.6121.00
23_L27_L0.6101.00
96_L99_L0.6061.00
133_I136_P0.6041.00
41_S45_L0.6011.00
24_L28_F0.5981.00
113_L116_L0.5961.00
191_L195_A0.5961.00
161_L164_L0.5961.00
155_F159_F0.5911.00
36_F41_S0.5871.00
185_S191_L0.5831.00
18_L26_I0.5801.00
98_L101_A0.5791.00
115_P118_G0.5771.00
38_L44_L0.5751.00
56_F139_F0.5731.00
64_T70_T0.5671.00
178_R181_I0.5651.00
40_F49_A0.5621.00
111_L116_L0.5591.00
106_L109_G0.5571.00
134_G140_K0.5561.00
47_L51_L0.5561.00
22_L32_L0.5501.00
57_A60_E0.5491.00
21_L24_L0.5441.00
85_A89_L0.5441.00
120_Y123_L0.5411.00
183_F197_S0.5411.00
79_V83_Y0.5371.00
42_L48_A0.5301.00
138_S143_N0.5271.00
66_E70_T0.5251.00
93_A97_T0.5251.00
148_I151_F0.5221.00
135_L139_F0.5191.00
23_L29_F0.5181.00
119_G123_L0.5110.99
196_L199_F0.5090.99
127_G130_F0.5050.99
97_T120_Y0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j1zP 8 0.6505 1.4 0.937 Contact Map
3ne5A 3 0.6893 1.2 0.941 Contact Map
4qndA 2 0.301 1.1 0.942 Contact Map
2pq4B 1 0.1699 1 0.943 Contact Map
1zx3A 3 0.1748 1 0.943 Contact Map
4yl6B 1 0.0583 0.9 0.945 Contact Map
1jb0M 1 0.1505 0.9 0.945 Contact Map
3plvC 1 0.1019 0.8 0.947 Contact Map
1fdmA 1 0.2087 0.8 0.947 Contact Map
2nq2A 2 0.2524 0.7 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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