AATF-Che1 - PFAM28P - GREMLIN Contacts

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AATF-Che1 - Apoptosis antagonizing transcription factor

PFAM:	PF13339	Sequences: DAEKGKAVKNQRALWDSLLEARIKLQKALTAANRLPQPDTFSEFKEEEVSEALKAAEKAALKLLDSLLELREALEQNPTESSETGKKRKRKSPPKRKTSLDELWERIQKLEAAFLPYRNATLDKWSRK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	128 (128)
Sequences:	720 (584)
Seq/√Len:	51.6
META:	0.24

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
117_Y	121_T	4.196	1.00
22_R	26_Q	3.721	1.00
18_L	63_L	3.538	1.00
123_D	127_R	2.820	1.00
122_L	126_S	2.618	1.00
85_G	88_R	2.316	1.00
87_K	92_S	2.311	1.00
57_E	64_L	2.237	1.00
25_L	28_A	2.065	1.00
33_N	36_P	2.053	1.00
87_K	93_P	1.985	1.00
125_W	128_K	1.952	1.00
65_D	103_L	1.897	0.99
88_R	91_K	1.887	0.99
64_L	103_L	1.872	0.99
87_K	91_K	1.832	0.99
5_G	27_K	1.817	0.99
113_A	116_P	1.798	0.99
104_W	123_D	1.781	0.99
82_S	86_K	1.775	0.99
12_R	15_W	1.741	0.99
115_L	119_N	1.733	0.99
64_L	68_L	1.726	0.99
16_D	121_T	1.679	0.98
56_A	60_A	1.645	0.98
7_A	16_D	1.638	0.98
2_A	5_G	1.598	0.98
22_R	25_L	1.534	0.97
119_N	123_D	1.483	0.97
4_K	11_Q	1.476	0.97
96_R	99_S	1.446	0.96
71_R	111_E	1.425	0.96
13_A	52_A	1.392	0.95
9_K	104_W	1.389	0.95
5_G	8_V	1.300	0.93
62_K	100_L	1.295	0.93
20_E	24_K	1.278	0.92
58_K	67_L	1.276	0.92
33_N	118_R	1.260	0.92
85_G	89_K	1.247	0.92
24_K	103_L	1.239	0.91
37_Q	128_K	1.236	0.91
15_W	127_R	1.187	0.89
2_A	6_K	1.185	0.89
15_W	34_R	1.181	0.89
68_L	74_L	1.166	0.89
115_L	121_T	1.165	0.89
89_K	92_S	1.153	0.88
2_A	9_K	1.147	0.88
46_E	101_D	1.147	0.88
22_R	27_K	1.137	0.87
81_S	84_T	1.124	0.87
8_V	118_R	1.106	0.86
84_T	91_K	1.095	0.85
67_L	74_L	1.094	0.85
4_K	8_V	1.073	0.84
21_A	112_A	1.064	0.83
3_E	6_K	1.060	0.83
2_A	18_L	1.050	0.83
1_D	5_G	1.030	0.81
81_S	85_G	1.027	0.81
15_W	20_E	1.018	0.81
23_I	27_K	1.018	0.81
26_Q	125_W	1.003	0.80
108_Q	112_A	1.001	0.80
35_L	125_W	0.982	0.78
18_L	121_T	0.978	0.78
39_D	69_E	0.977	0.78
80_E	83_E	0.969	0.77
30_T	34_R	0.964	0.77
17_S	128_K	0.948	0.76
7_A	24_K	0.948	0.76
81_S	88_R	0.939	0.75
61_L	66_S	0.929	0.74
83_E	86_K	0.918	0.73
14_L	117_Y	0.908	0.73
24_K	66_S	0.907	0.72
38_P	43_E	0.906	0.72
72_E	105_E	0.902	0.72
22_R	125_W	0.900	0.72
63_L	67_L	0.894	0.71
15_W	114_F	0.891	0.71
64_L	107_I	0.890	0.71
105_E	109_K	0.888	0.71
35_L	110_L	0.882	0.70
39_D	101_D	0.876	0.70
60_A	99_S	0.876	0.70
61_L	103_L	0.875	0.70
59_A	66_S	0.868	0.69
31_A	58_K	0.851	0.68
14_L	71_R	0.847	0.67
104_W	127_R	0.845	0.67
66_S	72_E	0.842	0.67
110_L	127_R	0.835	0.66
71_R	110_L	0.833	0.66
20_E	29_L	0.833	0.66
6_K	32_A	0.827	0.65
85_G	92_S	0.823	0.65
16_D	52_A	0.822	0.65
54_K	113_A	0.815	0.64
4_K	124_K	0.815	0.64
115_L	118_R	0.811	0.64
109_K	112_A	0.811	0.64
7_A	59_A	0.808	0.63
82_S	92_S	0.804	0.63
64_L	111_E	0.792	0.62
85_G	93_P	0.791	0.62
121_T	128_K	0.744	0.57
1_D	6_K	0.729	0.56
20_E	57_E	0.727	0.55
21_A	113_A	0.725	0.55
40_T	44_F	0.718	0.54
61_L	110_L	0.718	0.54
9_K	33_N	0.717	0.54
82_S	93_P	0.710	0.54
15_W	71_R	0.708	0.53
95_K	98_T	0.706	0.53
16_D	102_E	0.704	0.53
12_R	30_T	0.701	0.53
84_T	94_P	0.701	0.53
49_V	79_T	0.698	0.52
86_K	90_R	0.685	0.51
17_S	32_A	0.683	0.51
86_K	92_S	0.679	0.50
12_R	127_R	0.675	0.50
68_L	117_Y	0.674	0.50
47_E	54_K	0.673	0.50
36_P	44_F	0.670	0.49
7_A	104_W	0.667	0.49
40_T	43_E	0.656	0.48
5_G	71_R	0.652	0.48
111_E	126_S	0.651	0.47
84_T	89_K	0.648	0.47
108_Q	113_A	0.645	0.47
66_S	69_E	0.644	0.47
49_V	70_L	0.643	0.47
28_A	119_N	0.640	0.46
43_E	69_E	0.637	0.46
63_L	126_S	0.636	0.46
47_E	53_L	0.636	0.46
59_A	72_E	0.631	0.45
50_S	53_L	0.624	0.45
39_D	120_A	0.615	0.44
6_K	9_K	0.614	0.44
117_Y	127_R	0.612	0.43
48_E	54_K	0.606	0.43
100_L	103_L	0.603	0.43
36_P	125_W	0.603	0.43
33_N	124_K	0.600	0.42
82_S	90_R	0.599	0.42
19_L	123_D	0.597	0.42
86_K	91_K	0.592	0.41
111_E	128_K	0.587	0.41
55_A	60_A	0.586	0.41
9_K	16_D	0.584	0.41
114_F	120_A	0.583	0.41
18_L	26_Q	0.582	0.40
10_N	21_A	0.581	0.40
17_S	34_R	0.579	0.40
80_E	84_T	0.574	0.40
15_W	19_L	0.572	0.39
36_P	114_F	0.563	0.39
49_V	52_A	0.561	0.38
54_K	116_P	0.555	0.38
64_L	118_R	0.551	0.37
75_E	78_P	0.551	0.37
12_R	24_K	0.540	0.36
7_A	64_L	0.539	0.36
114_F	128_K	0.538	0.36
13_A	32_A	0.537	0.36
109_K	122_L	0.537	0.36
1_D	71_R	0.537	0.36
2_A	121_T	0.533	0.36
44_F	122_L	0.532	0.36
118_R	124_K	0.531	0.35
103_L	122_L	0.530	0.35
32_A	51_E	0.530	0.35
69_E	128_K	0.529	0.35
3_E	29_L	0.528	0.35
87_K	90_R	0.527	0.35
19_L	23_I	0.525	0.35
24_K	61_L	0.524	0.35
37_Q	40_T	0.523	0.35
6_K	35_L	0.522	0.35
91_K	116_P	0.521	0.34
53_L	56_A	0.520	0.34
49_V	61_L	0.512	0.34
41_F	44_F	0.509	0.33
6_K	74_L	0.504	0.33
51_E	58_K	0.503	0.33
5_G	18_L	0.502	0.33
68_L	119_N	0.500	0.33

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
5c0xK	1	0	7.7	0.915	Contact Map
2d4yA	1	0.8203	5.4	0.921	Contact Map
4wfcA	1	0.7266	4.6	0.924	Contact Map
4ecgA	1	0.5547	3.8	0.926	Contact Map
1wh2A	1	0.3438	2.7	0.932	Contact Map
4yjwA	1	0.875	2.2	0.935	Contact Map
2p22C	2	0.7969	2.1	0.936	Contact Map
2vj4A	1	0.4609	1.9	0.937	Contact Map
1pgyA	1	0.2188	1.7	0.939	Contact Map
1x4aA	1	0.2891	1.7	0.939	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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