GREMLIN Database
AATF-Che1 - Apoptosis antagonizing transcription factor
PFAM: PF13339 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 128 (128)
Sequences: 720 (584)
Seq/√Len: 51.6
META: 0.24

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
117_Y121_T4.1961.00
22_R26_Q3.7211.00
18_L63_L3.5381.00
123_D127_R2.8201.00
122_L126_S2.6181.00
85_G88_R2.3161.00
87_K92_S2.3111.00
57_E64_L2.2371.00
25_L28_A2.0651.00
33_N36_P2.0531.00
87_K93_P1.9851.00
125_W128_K1.9521.00
65_D103_L1.8970.99
88_R91_K1.8870.99
64_L103_L1.8720.99
87_K91_K1.8320.99
5_G27_K1.8170.99
113_A116_P1.7980.99
104_W123_D1.7810.99
82_S86_K1.7750.99
12_R15_W1.7410.99
115_L119_N1.7330.99
64_L68_L1.7260.99
16_D121_T1.6790.98
56_A60_A1.6450.98
7_A16_D1.6380.98
2_A5_G1.5980.98
22_R25_L1.5340.97
119_N123_D1.4830.97
4_K11_Q1.4760.97
96_R99_S1.4460.96
71_R111_E1.4250.96
13_A52_A1.3920.95
9_K104_W1.3890.95
5_G8_V1.3000.93
62_K100_L1.2950.93
20_E24_K1.2780.92
58_K67_L1.2760.92
33_N118_R1.2600.92
85_G89_K1.2470.92
24_K103_L1.2390.91
37_Q128_K1.2360.91
15_W127_R1.1870.89
2_A6_K1.1850.89
15_W34_R1.1810.89
68_L74_L1.1660.89
115_L121_T1.1650.89
89_K92_S1.1530.88
2_A9_K1.1470.88
46_E101_D1.1470.88
22_R27_K1.1370.87
81_S84_T1.1240.87
8_V118_R1.1060.86
84_T91_K1.0950.85
67_L74_L1.0940.85
4_K8_V1.0730.84
21_A112_A1.0640.83
3_E6_K1.0600.83
2_A18_L1.0500.83
1_D5_G1.0300.81
81_S85_G1.0270.81
15_W20_E1.0180.81
23_I27_K1.0180.81
26_Q125_W1.0030.80
108_Q112_A1.0010.80
35_L125_W0.9820.78
18_L121_T0.9780.78
39_D69_E0.9770.78
80_E83_E0.9690.77
30_T34_R0.9640.77
17_S128_K0.9480.76
7_A24_K0.9480.76
81_S88_R0.9390.75
61_L66_S0.9290.74
83_E86_K0.9180.73
14_L117_Y0.9080.73
24_K66_S0.9070.72
38_P43_E0.9060.72
72_E105_E0.9020.72
22_R125_W0.9000.72
63_L67_L0.8940.71
15_W114_F0.8910.71
64_L107_I0.8900.71
105_E109_K0.8880.71
35_L110_L0.8820.70
39_D101_D0.8760.70
60_A99_S0.8760.70
61_L103_L0.8750.70
59_A66_S0.8680.69
31_A58_K0.8510.68
14_L71_R0.8470.67
104_W127_R0.8450.67
66_S72_E0.8420.67
110_L127_R0.8350.66
71_R110_L0.8330.66
20_E29_L0.8330.66
6_K32_A0.8270.65
85_G92_S0.8230.65
16_D52_A0.8220.65
54_K113_A0.8150.64
4_K124_K0.8150.64
115_L118_R0.8110.64
109_K112_A0.8110.64
7_A59_A0.8080.63
82_S92_S0.8040.63
64_L111_E0.7920.62
85_G93_P0.7910.62
121_T128_K0.7440.57
1_D6_K0.7290.56
20_E57_E0.7270.55
21_A113_A0.7250.55
40_T44_F0.7180.54
61_L110_L0.7180.54
9_K33_N0.7170.54
82_S93_P0.7100.54
15_W71_R0.7080.53
95_K98_T0.7060.53
16_D102_E0.7040.53
12_R30_T0.7010.53
84_T94_P0.7010.53
49_V79_T0.6980.52
86_K90_R0.6850.51
17_S32_A0.6830.51
86_K92_S0.6790.50
12_R127_R0.6750.50
68_L117_Y0.6740.50
47_E54_K0.6730.50
36_P44_F0.6700.49
7_A104_W0.6670.49
40_T43_E0.6560.48
5_G71_R0.6520.48
111_E126_S0.6510.47
84_T89_K0.6480.47
108_Q113_A0.6450.47
66_S69_E0.6440.47
49_V70_L0.6430.47
28_A119_N0.6400.46
43_E69_E0.6370.46
63_L126_S0.6360.46
47_E53_L0.6360.46
59_A72_E0.6310.45
50_S53_L0.6240.45
39_D120_A0.6150.44
6_K9_K0.6140.44
117_Y127_R0.6120.43
48_E54_K0.6060.43
100_L103_L0.6030.43
36_P125_W0.6030.43
33_N124_K0.6000.42
82_S90_R0.5990.42
19_L123_D0.5970.42
86_K91_K0.5920.41
111_E128_K0.5870.41
55_A60_A0.5860.41
9_K16_D0.5840.41
114_F120_A0.5830.41
18_L26_Q0.5820.40
10_N21_A0.5810.40
17_S34_R0.5790.40
80_E84_T0.5740.40
15_W19_L0.5720.39
36_P114_F0.5630.39
49_V52_A0.5610.38
54_K116_P0.5550.38
64_L118_R0.5510.37
75_E78_P0.5510.37
12_R24_K0.5400.36
7_A64_L0.5390.36
114_F128_K0.5380.36
13_A32_A0.5370.36
109_K122_L0.5370.36
1_D71_R0.5370.36
2_A121_T0.5330.36
44_F122_L0.5320.36
118_R124_K0.5310.35
103_L122_L0.5300.35
32_A51_E0.5300.35
69_E128_K0.5290.35
3_E29_L0.5280.35
87_K90_R0.5270.35
19_L23_I0.5250.35
24_K61_L0.5240.35
37_Q40_T0.5230.35
6_K35_L0.5220.35
91_K116_P0.5210.34
53_L56_A0.5200.34
49_V61_L0.5120.34
41_F44_F0.5090.33
6_K74_L0.5040.33
51_E58_K0.5030.33
5_G18_L0.5020.33
68_L119_N0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5c0xK 1 0 7.7 0.915 Contact Map
2d4yA 1 0.8203 5.4 0.921 Contact Map
4wfcA 1 0.7266 4.6 0.924 Contact Map
4ecgA 1 0.5547 3.8 0.926 Contact Map
1wh2A 1 0.3438 2.7 0.932 Contact Map
4yjwA 1 0.875 2.2 0.935 Contact Map
2p22C 2 0.7969 2.1 0.936 Contact Map
2vj4A 1 0.4609 1.9 0.937 Contact Map
1pgyA 1 0.2188 1.7 0.939 Contact Map
1x4aA 1 0.2891 1.7 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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