GREMLIN Database
Fil_haemagg_2 - Haemagluttinin repeat
PFAM: PF13332 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 170 (161)
Sequences: 6285 (4839)
Seq/√Len: 381.3
META: 0.555

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_I126_I3.2861.00
38_T59_N3.1501.00
130_G150_G3.0561.00
37_I52_L3.0311.00
39_V42_S3.0211.00
46_A50_V2.9761.00
133_T153_N2.9021.00
128_S132_T2.7131.00
124_V139_V2.6671.00
53_S127_N2.4551.00
34_G56_N2.4521.00
134_L137_A2.2461.00
51_T125_T2.1101.00
40_Q61_L2.0731.00
141_A144_V2.0621.00
62_A113_Q2.0561.00
57_D130_G1.9881.00
50_V118_V1.9181.00
65_N114_T1.9161.00
28_V44_V1.8971.00
17_A65_N1.8771.00
135_K155_E1.8711.00
60_L116_S1.8611.00
56_N130_G1.8591.00
115_N137_A1.8531.00
32_A37_I1.7901.00
38_T61_L1.7851.00
14_S67_S1.7341.00
21_T43_Q1.7251.00
144_V148_A1.7151.00
62_A157_A1.7021.00
113_Q157_A1.7001.00
131_D151_N1.6951.00
24_A28_V1.6791.00
110_S161_S1.6481.00
36_D56_N1.5831.00
26_G48_G1.5781.00
64_Q113_Q1.5721.00
45_S119_G1.5471.00
59_N133_T1.5461.00
39_V60_L1.5371.00
115_N138_Q1.5131.00
43_Q117_T1.5051.00
132_T146_A1.5001.00
64_Q111_T1.4601.00
63_A114_T1.4521.00
29_T51_T1.4501.00
36_D57_D1.4181.00
113_Q159_D1.4101.00
17_A63_A1.3591.00
39_V44_V1.3451.00
54_A129_G1.3441.00
120_A124_V1.3201.00
23_S45_S1.3021.00
123_N143_D1.2851.00
13_S68_S1.2791.00
86_L89_G1.2751.00
131_D150_G1.2331.00
132_T148_A1.2211.00
135_K157_A1.2121.00
127_N147_D1.2061.00
68_S109_D1.2001.00
58_I128_S1.1921.00
77_G100_S1.1911.00
124_V141_A1.1851.00
41_G63_A1.1711.00
113_Q136_G1.1701.00
31_T53_S1.1501.00
27_N48_G1.1241.00
30_I37_I1.1191.00
49_D123_N1.1111.00
78_A82_V1.1031.00
117_T138_Q1.0921.00
60_L134_L1.0861.00
126_I146_A1.0861.00
125_T145_T1.0731.00
50_V124_V1.0551.00
10_S71_S1.0531.00
15_T66_T1.0401.00
75_S102_G1.0391.00
19_G42_S1.0391.00
143_D146_A1.0291.00
134_L154_I1.0271.00
20_S42_S1.0211.00
40_Q63_A1.0121.00
148_A152_L1.0011.00
43_Q114_T1.0001.00
133_T155_E0.9981.00
122_G142_G0.9701.00
37_I58_I0.9691.00
109_D162_T0.9421.00
60_L137_A0.9381.00
17_A41_G0.9181.00
50_V53_S0.8861.00
119_G140_S0.8811.00
8_S73_N0.8691.00
44_V118_V0.8631.00
73_N104_G0.8531.00
142_G145_T0.8471.00
19_G43_Q0.8291.00
15_T18_V0.8271.00
37_I54_A0.8181.00
12_S69_S0.8121.00
79_S83_S0.8091.00
5_K76_S0.8041.00
139_V154_I0.8031.00
116_S137_A0.8011.00
49_D125_T0.7951.00
48_G122_G0.7901.00
61_L135_K0.7891.00
36_D54_A0.7811.00
67_S110_S0.7801.00
86_L92_G0.7761.00
108_G163_Y0.7741.00
106_S165_S0.7731.00
31_T127_N0.7731.00
123_N145_T0.7711.00
52_L126_I0.7691.00
28_V50_V0.7661.00
85_G89_G0.7521.00
46_A49_D0.7501.00
49_D122_G0.7491.00
136_G157_A0.7421.00
79_S98_G0.7411.00
17_A40_Q0.7301.00
85_G88_G0.7301.00
33_G37_I0.7301.00
83_S86_L0.7301.00
87_G90_G0.7301.00
27_N46_A0.7211.00
76_S101_K0.7161.00
27_N120_A0.7121.00
120_A123_N0.7081.00
126_I139_V0.7071.00
142_G147_D0.7061.00
124_V144_V0.7061.00
54_A58_I0.7031.00
52_L118_V0.7021.00
28_V46_A0.6980.99
47_G121_G0.6950.99
24_A27_N0.6820.99
132_T149_G0.6810.99
12_S67_S0.6800.99
53_S56_N0.6770.99
115_N157_A0.6760.99
123_N142_G0.6680.99
33_G55_G0.6630.99
36_D129_G0.6630.99
87_G92_G0.6630.99
101_K105_K0.6600.99
17_A114_T0.6520.99
126_I132_T0.6500.99
143_D148_A0.6500.99
32_A56_N0.6450.99
27_N49_D0.6440.99
92_G95_V0.6430.99
22_L28_V0.6400.99
26_G47_G0.6370.99
15_T65_N0.6370.99
111_T160_T0.6350.99
16_T65_N0.6260.99
128_S148_A0.6240.99
32_A55_G0.6180.99
54_A128_S0.6170.99
34_G55_G0.6140.99
20_S39_V0.6110.99
50_V120_A0.6100.99
136_G158_Q0.6100.99
144_V152_L0.6080.99
22_L30_I0.6070.99
83_S94_G0.6040.99
36_D55_G0.6030.98
84_V93_I0.6020.98
19_G114_T0.6000.98
77_G102_G0.5950.98
84_V87_G0.5940.98
7_K11_T0.5910.98
81_G84_V0.5900.98
85_G90_G0.5880.98
132_T152_L0.5870.98
144_V147_D0.5840.98
149_G152_L0.5840.98
60_L118_V0.5830.98
66_T111_T0.5810.98
89_G92_G0.5810.98
20_S23_S0.5790.98
30_I44_V0.5730.98
83_S96_T0.5700.98
83_S89_G0.5680.98
162_T166_K0.5670.98
70_S107_N0.5660.98
77_G80_V0.5660.98
42_S116_S0.5650.98
80_V83_S0.5630.98
54_A57_D0.5620.98
86_L90_G0.5590.98
5_K8_S0.5580.98
88_G96_T0.5570.97
88_G93_I0.5570.97
116_S119_G0.5560.97
71_S75_S0.5520.97
156_S159_D0.5520.97
103_K107_N0.5510.97
83_S87_G0.5510.97
134_L139_V0.5490.97
69_S107_N0.5480.97
94_G97_A0.5470.97
70_S109_D0.5460.97
78_A81_G0.5460.97
144_V150_G0.5450.97
131_D153_N0.5440.97
118_V139_V0.5440.97
128_S150_G0.5430.97
94_G98_G0.5420.97
5_K9_T0.5340.97
83_S92_G0.5320.97
57_D131_D0.5320.97
19_G22_L0.5310.97
135_K138_Q0.5310.97
44_V50_V0.5300.97
84_V89_G0.5280.97
144_V149_G0.5270.97
106_S163_Y0.5250.96
24_A46_A0.5250.96
95_V99_A0.5240.96
74_S79_S0.5230.96
109_D164_S0.5220.96
28_V32_A0.5200.96
108_G161_S0.5190.96
145_T148_A0.5180.96
7_K74_S0.5180.96
71_S106_S0.5140.96
102_G106_S0.5090.96
80_V84_V0.5080.96
24_A47_G0.5070.96
131_D149_G0.5050.96
61_L64_Q0.5040.96
32_A54_A0.5030.95
31_T51_T0.5030.95
18_V21_T0.5020.95
9_T13_S0.5020.95
88_G92_G0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wthA 3 0.4882 17.5 0.875 Contact Map
4i84A 1 0.7647 8.3 0.892 Contact Map
4ku0A 3 0.4059 5.7 0.9 Contact Map
4mtkA 4 0.6118 2.4 0.917 Contact Map
4peuA 1 0.8588 2.1 0.92 Contact Map
1s7mA 5 0.3176 1.3 0.928 Contact Map
1rwrA 1 0.5412 1.1 0.932 Contact Map
3a1mA 5 0.4941 1 0.933 Contact Map
2jcbA 1 0.3176 0.9 0.936 Contact Map
1wxrA 1 0.9588 0.5 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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