GREMLIN Database
Mucin2_WxxW - Mucin-2 protein WxxW repeating region
PFAM: PF13330 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 84 (84)
Sequences: 1864 (1466)
Seq/√Len: 160.0
META: 0.387

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_C57_C4.5221.00
40_R79_E4.3881.00
38_E81_R4.1351.00
53_Q76_L2.8351.00
6_F23_L2.5701.00
55_V63_L2.1501.00
14_G17_F2.1431.00
7_D10_D2.0371.00
7_D42_V1.9981.00
15_G67_N1.9581.00
56_T69_D1.9011.00
53_Q72_G1.7521.00
42_V79_E1.7051.00
53_Q78_Y1.7001.00
36_A83_L1.6691.00
41_A44_T1.6271.00
57_C63_L1.5801.00
58_D61_V1.5431.00
24_R30_V1.5051.00
23_L82_F1.3921.00
9_D13_G1.3181.00
56_T64_V1.2921.00
57_C83_L1.2831.00
3_T82_F1.2831.00
41_A51_L1.2591.00
70_Q74_M1.2351.00
70_Q73_G1.2061.00
39_C63_L1.2001.00
66_R69_D1.2001.00
8_R23_L1.1981.00
48_L51_L1.1611.00
9_D16_D1.1591.00
5_W38_E1.1461.00
41_A76_L1.1431.00
8_R22_N1.1391.00
7_D77_D1.1291.00
17_F66_R1.1261.00
17_F64_V1.0610.99
46_V50_E1.0600.99
65_C75_C1.0590.99
24_R32_E1.0210.99
35_T83_L0.9940.99
37_I80_V0.9850.99
1_E83_L0.9840.99
37_I82_F0.9830.99
16_D78_Y0.9630.99
64_V69_D0.9390.98
20_L82_F0.9240.98
56_T66_R0.9160.98
45_G79_E0.9140.98
23_L80_V0.8900.98
19_T22_N0.8700.97
40_R45_G0.8560.97
63_L78_Y0.8560.97
23_L26_Y0.8470.97
38_E83_L0.8180.96
39_C83_L0.7990.96
54_V69_D0.7930.96
6_F30_V0.7900.96
53_Q70_Q0.7840.95
2_W83_L0.7730.95
47_P50_E0.7690.95
20_L24_R0.7650.95
5_W81_R0.7620.95
18_E37_I0.7460.94
35_T72_G0.7340.93
21_S25_A0.7320.93
10_D77_D0.7290.93
3_T34_P0.7290.93
27_G39_C0.7200.93
48_L55_V0.7130.92
20_L30_V0.7000.92
3_T6_F0.6880.91
41_A52_G0.6810.91
8_R14_G0.6710.90
4_D81_R0.6690.90
67_N70_Q0.6500.89
11_P16_D0.6420.88
75_C84_C0.6370.88
20_L59_L0.6320.87
37_I59_L0.6200.86
23_L30_V0.6190.86
46_V52_G0.6160.86
54_V70_Q0.6090.85
48_L66_R0.6030.85
41_A48_L0.6000.84
8_R19_T0.5980.84
4_D28_Y0.5910.83
29_K35_T0.5900.83
36_A81_R0.5880.83
48_L52_G0.5880.83
4_D29_K0.5820.82
8_R25_A0.5820.82
31_C84_C0.5780.82
47_P63_L0.5730.82
34_P70_Q0.5600.80
2_W36_A0.5550.79
43_G52_G0.5540.79
8_R26_Y0.5530.79
1_E34_P0.5510.79
44_T48_L0.5500.79
29_K68_S0.5440.78
32_E54_V0.5400.78
9_D12_S0.5350.77
52_G57_C0.5310.76
56_T61_V0.5310.76
45_G48_L0.5290.76
45_G52_G0.5280.76
52_G70_Q0.5260.76
77_D84_C0.5260.76
6_F28_Y0.5230.75
47_P51_L0.5200.75
6_F29_K0.5150.74
35_T45_G0.5120.74
42_V77_D0.5090.73
4_D35_T0.5060.73
29_K32_E0.5050.73
24_R27_G0.5050.73
75_C78_Y0.5050.73
30_V36_A0.5030.73
10_D16_D0.5030.73
4_D13_G0.5030.73
60_S74_M0.5020.72
41_A46_V0.5010.72
8_R11_P0.5010.72
20_L23_L0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4e45E 1 0.5476 6.8 0.9 Contact Map
2lpbB 1 0.1905 4.2 0.909 Contact Map
1e0fI 1 0.2262 2 0.923 Contact Map
3keyA 1 0.2619 1.7 0.925 Contact Map
3ojyA 1 0.381 1.7 0.926 Contact Map
2jq3A 1 0.3214 1.6 0.927 Contact Map
1l3aA 4 0.3095 1.6 0.927 Contact Map
2dcvA 1 0.2381 1.6 0.927 Contact Map
4jd0A 1 0.369 1.5 0.928 Contact Map
4m1gA 2 0.381 1.4 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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