GREMLIN Database
DUF4091 - Domain of unknown function (DUF4091)
PFAM: PF13320 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 66 (64)
Sequences: 11116 (6861)
Seq/√Len: 857.6
META: 0.966

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_Y63_R2.9391.00
45_P49_L2.8131.00
45_P50_E2.7201.00
16_D19_T2.4481.00
18_W44_V2.4181.00
51_A54_D2.1831.00
60_E63_R2.0731.00
36_Y46_S2.0501.00
53_R57_E1.9681.00
10_Y35_V1.9511.00
54_D57_E1.9291.00
35_V49_L1.7901.00
61_Y64_L1.6061.00
60_E64_L1.5431.00
38_G41_G1.5381.00
9_G12_Y1.5361.00
57_E60_E1.4061.00
34_L52_L1.4011.00
47_I51_A1.3811.00
50_E57_E1.3201.00
52_L56_I1.2381.00
7_Y10_Y1.1281.00
21_P24_G1.0721.00
12_Y15_S1.0651.00
17_P21_P1.0521.00
22_D25_G1.0501.00
54_D58_D1.0421.00
7_Y52_L1.0411.00
61_Y65_L1.0231.00
38_G44_V1.0201.00
21_P25_G1.0071.00
39_P44_V1.0061.00
51_A55_G0.9701.00
20_D24_G0.9631.00
50_E54_D0.9591.00
28_P31_D0.9291.00
38_G43_P0.9261.00
58_D61_Y0.9201.00
10_Y49_L0.9101.00
7_Y31_D0.8811.00
34_L49_L0.8581.00
7_Y32_G0.8501.00
38_G42_G0.8491.00
5_F52_L0.8331.00
16_D20_D0.8261.00
6_L9_G0.8171.00
20_D23_A0.8101.00
49_L53_R0.8001.00
8_W12_Y0.7901.00
51_A56_I0.7831.00
18_W23_A0.7811.00
20_D25_G0.7741.00
28_P33_F0.7731.00
17_P22_D0.7681.00
8_W11_N0.7631.00
17_P20_D0.7321.00
15_S27_W0.7261.00
23_A32_G0.7231.00
56_I60_E0.7121.00
11_N14_T0.7111.00
19_T39_P0.7091.00
19_T22_D0.7001.00
18_W21_P0.6991.00
7_Y34_L0.6921.00
30_G48_R0.6861.00
15_S24_G0.6721.00
50_E53_R0.6711.00
18_W22_D0.6591.00
50_E65_L0.6591.00
17_P37_P0.6361.00
16_D22_D0.6331.00
17_P23_A0.6321.00
46_S51_A0.6091.00
14_T23_A0.6081.00
6_L10_Y0.6011.00
23_A33_F0.5791.00
39_P42_G0.5771.00
45_P51_A0.5761.00
54_D60_E0.5761.00
15_S26_G0.5721.00
33_F36_Y0.5501.00
4_G7_Y0.5501.00
34_L48_R0.5421.00
14_T22_D0.5371.00
18_W24_G0.5321.00
22_D29_N0.5321.00
29_N32_G0.5311.00
9_G14_T0.5231.00
37_P47_I0.5211.00
53_R60_E0.5121.00
48_R60_E0.5091.00
35_V45_P0.5091.00
15_S25_G0.5071.00
35_V43_P0.5041.00
26_G63_R0.5011.00
19_T24_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3g4nA 1 0.8788 15.3 0.855 Contact Map
3sf4D 1 0.3636 9.1 0.869 Contact Map
1ll7A 1 0.8333 8 0.873 Contact Map
3g6mA 1 0.7424 5.8 0.88 Contact Map
1w9pA 1 0.8333 5.8 0.881 Contact Map
1nq6A 1 0.6364 4.8 0.885 Contact Map
4qp0A 1 0.6515 4.5 0.886 Contact Map
1i1wA 1 0.6667 3.5 0.892 Contact Map
2axoA 2 0 3.1 0.895 Contact Map
4d1iA 4 0.7879 2.8 0.897 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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