GREMLIN Database
DUF4082 - Domain of unknown function (DUF4082)
PFAM: PF13313 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 149 (148)
Sequences: 14739 (11779)
Seq/√Len: 968.2
META: 0.94

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_S59_L3.9171.00
63_A76_V3.6541.00
50_G65_F2.9671.00
113_D118_H2.8891.00
32_Y83_A2.7861.00
130_A136_A2.7311.00
54_S58_T2.5641.00
28_D118_H2.4791.00
122_D144_A2.3991.00
106_G143_N2.3961.00
20_E51_S2.2511.00
51_S62_T2.2371.00
33_I84_I2.1981.00
36_I92_A1.9721.00
59_L62_T1.9441.00
130_A140_S1.9181.00
105_S143_N1.9151.00
19_V131_Y1.8771.00
30_A86_A1.8071.00
45_T98_N1.7871.00
27_S84_I1.7461.00
3_S6_A1.7181.00
20_E135_S1.7101.00
51_S135_S1.7071.00
52_L82_V1.6671.00
104_D148_W1.6471.00
30_A85_T1.6011.00
103_A145_S1.5981.00
23_V92_A1.5641.00
43_G100_H1.5451.00
130_A139_T1.5441.00
12_D100_H1.5401.00
107_Y112_V1.5351.00
36_I78_F1.5261.00
61_A82_V1.5171.00
13_A103_A1.5071.00
106_G109_A1.4961.00
12_D43_G1.4821.00
125_G141_T1.4721.00
53_W93_S1.4581.00
37_R75_Q1.4321.00
24_K55_S1.3841.00
26_R89_T1.3671.00
48_H68_E1.3661.00
24_K89_T1.3471.00
40_K68_E1.3401.00
34_T77_T1.3161.00
51_S93_S1.3111.00
36_I50_G1.2971.00
105_S145_S1.2831.00
35_G77_T1.2651.00
24_K128_V1.2481.00
95_H135_S1.2381.00
41_G102_A1.2381.00
2_W6_A1.2381.00
26_R120_L1.2371.00
132_G136_A1.2321.00
9_A104_D1.2271.00
27_S30_A1.2101.00
35_G78_F1.1601.00
10_T41_G1.1481.00
47_T64_T1.1451.00
55_S91_V1.1321.00
27_S117_L1.1271.00
28_D116_P1.1111.00
18_A95_H1.1091.00
24_K124_G1.0811.00
122_D125_G1.0781.00
28_D115_G1.0711.00
109_A144_A1.0661.00
91_V137_F1.0661.00
6_A112_V1.0511.00
142_Y145_S1.0501.00
44_N48_H1.0381.00
91_V128_V1.0331.00
11_P102_A1.0121.00
108_F119_A0.9921.00
16_T100_H0.9921.00
104_D107_Y0.9911.00
95_H134_A0.9861.00
78_F92_A0.9731.00
44_N102_A0.9631.00
89_T120_L0.9561.00
62_T135_S0.9531.00
40_K74_Q0.9511.00
13_A100_H0.9501.00
50_G63_A0.9351.00
49_V64_T0.9291.00
85_T88_T0.9261.00
20_E95_H0.9061.00
111_G118_H0.8901.00
30_A83_A0.8891.00
111_G119_A0.8831.00
31_G84_I0.8711.00
38_F48_H0.8701.00
25_F90_Y0.8701.00
51_S95_H0.8641.00
141_T145_S0.8641.00
15_D101_Y0.8641.00
119_A126_N0.8631.00
36_I63_A0.8631.00
10_T13_A0.8561.00
69_T74_Q0.8511.00
54_S91_V0.8501.00
13_A105_S0.8471.00
54_S57_G0.8431.00
27_S86_A0.8431.00
107_Y146_N0.8321.00
35_G75_Q0.8171.00
133_S136_A0.8091.00
23_V146_N0.8061.00
19_V96_A0.8061.00
129_Y140_S0.7891.00
14_N100_H0.7861.00
3_S114_N0.7671.00
10_T103_A0.7671.00
25_F52_L0.7661.00
63_A79_S0.7651.00
20_E93_S0.7621.00
15_D19_V0.7521.00
113_D117_L0.7481.00
12_D41_G0.7461.00
26_R87_N0.7391.00
26_R118_H0.7381.00
20_E132_G0.7331.00
68_E74_Q0.7321.00
121_A125_G0.7151.00
41_G44_N0.7141.00
61_A79_S0.7101.00
103_A106_G0.6981.00
55_S137_F0.6941.00
37_R73_W0.6931.00
107_Y148_W0.6921.00
29_V116_P0.6921.00
33_I52_L0.6741.00
41_G100_H0.6661.00
106_G145_S0.6661.00
111_G121_A0.6621.00
39_Y72_G0.6601.00
106_G144_A0.6571.00
21_L94_Y0.6521.00
15_D131_Y0.6491.00
4_S75_Q0.6481.00
115_G118_H0.6471.00
7_T11_P0.6441.00
16_T19_V0.6381.00
6_A148_W0.6321.00
120_L126_N0.6231.00
55_S89_T0.6221.00
44_N94_Y0.6211.00
106_G110_S0.6171.00
10_T102_A0.6161.00
95_H136_A0.6161.00
54_S60_L0.6161.00
122_D141_T0.6121.00
12_D42_A0.6121.00
96_A100_H0.6111.00
11_P41_G0.6101.00
49_V62_T0.6101.00
17_S131_Y0.6081.00
10_T105_S0.6051.00
44_N100_H0.6021.00
121_A144_A0.6011.00
40_K71_S0.6011.00
50_G76_V0.6001.00
109_A122_D0.6001.00
76_V92_A0.5911.00
13_A16_T0.5851.00
54_S88_T0.5811.00
10_T104_D0.5781.00
131_Y147_Y0.5771.00
100_H103_A0.5741.00
107_Y119_A0.5701.00
61_A76_V0.5691.00
2_W148_W0.5691.00
105_S142_Y0.5691.00
22_G91_V0.5681.00
53_W59_L0.5661.00
54_S59_L0.5621.00
23_V119_A0.5621.00
63_A66_T0.5611.00
59_L135_S0.5611.00
8_P41_G0.5581.00
112_V119_A0.5581.00
120_L123_G0.5581.00
83_A86_A0.5541.00
2_W23_V0.5541.00
120_L124_G0.5531.00
36_I52_L0.5501.00
103_A142_Y0.5471.00
95_H132_G0.5461.00
59_L63_A0.5441.00
110_S121_A0.5441.00
84_I90_Y0.5421.00
132_G135_S0.5411.00
68_E71_S0.5411.00
40_K48_H0.5401.00
21_L96_A0.5401.00
130_A135_S0.5331.00
54_S137_F0.5261.00
57_G137_F0.5251.00
20_E62_T0.5241.00
52_L61_A0.5211.00
8_P104_D0.5211.00
61_A78_F0.5201.00
25_F33_I0.5191.00
23_V112_V0.5191.00
41_G104_D0.5161.00
3_S7_T0.5151.00
129_Y147_Y0.5111.00
101_Y105_S0.5111.00
25_F84_I0.5101.00
129_Y145_S0.5091.00
2_W146_N0.5081.00
78_F82_V0.5061.00
36_I76_V0.5051.00
104_D146_N0.5031.00
29_V32_Y0.5031.00
67_N70_A0.5021.00
33_I92_A0.5011.00
6_A9_A0.5011.00
103_A141_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3no8A 1 0.9128 70.3 0.869 Contact Map
3gbwA 1 0.9262 60.6 0.878 Contact Map
3hwjA 1 0.8725 56.6 0.88 Contact Map
3jqwA 1 0.6644 9.1 0.92 Contact Map
1nqjA 1 0.6309 9.1 0.92 Contact Map
3ua3A 2 0.8054 8.8 0.921 Contact Map
4m37A 2 0.6309 7.8 0.923 Contact Map
3n6yA 2 0.6174 5.7 0.927 Contact Map
1od3A 1 0.7114 5.7 0.927 Contact Map
3n3fA 3 0.2617 3.7 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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