GREMLIN Database
DUF4080 - Protein of unknown function (DUF4080)
PFAM: PF13311 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 188 (173)
Sequences: 2112 (1832)
Seq/√Len: 139.3
META: 0.724

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_V17_S3.7841.00
3_Y20_W3.4711.00
5_Y18_T3.3751.00
22_S25_E3.2551.00
14_E30_K3.1811.00
73_K91_E2.6851.00
28_R64_E2.6711.00
4_G19_K2.4981.00
58_S61_D2.4501.00
48_T104_L2.4321.00
90_L105_R2.4291.00
31_R71_E2.3601.00
51_Y107_L2.2511.00
93_L104_L2.2331.00
44_R82_L2.1641.00
65_E96_R2.1611.00
43_G46_D2.1431.00
47_H114_L2.0951.00
35_M66_L2.0611.00
31_R67_G1.9211.00
21_L26_I1.9161.00
16_L23_Y1.9021.00
53_I62_F1.8761.00
47_H110_F1.8031.00
21_L25_E1.7371.00
65_E92_F1.7231.00
84_D87_E1.6831.00
34_E38_K1.6671.00
106_E172_S1.6621.00
5_Y15_V1.6321.00
32_V67_G1.6131.00
87_E91_E1.5571.00
28_R68_D1.5211.00
2_E19_K1.5111.00
113_L121_R1.4981.00
138_R142_K1.4931.00
62_F66_L1.4791.00
94_E101_L1.4081.00
141_L166_T1.4041.00
15_V18_T1.3671.00
4_G17_S1.3661.00
32_V35_M1.3511.00
38_K85_L1.3441.00
80_H84_D1.3331.00
122_P125_L1.3221.00
143_N147_I1.3051.00
70_W85_L1.3021.00
148_P151_L1.2921.00
69_Y92_F1.2851.00
83_E112_Y1.2771.00
87_E124_F1.2531.00
75_Y88_I1.2511.00
52_L62_F1.2451.00
39_Y89_L1.1981.00
121_R125_L1.1981.00
61_D64_E1.1951.00
133_E137_I1.1931.00
52_L93_L1.1921.00
55_K100_D1.1921.00
28_R60_F1.1781.00
130_D133_E1.1781.00
44_R115_R1.1741.00
32_V36_L1.1640.99
151_L154_Y1.1540.99
148_P152_P1.1430.99
34_E37_E1.1340.99
53_I63_F1.1310.99
161_Q164_K1.1240.99
161_Q165_H1.1230.99
73_K95_E1.1060.99
143_N146_E1.1020.99
158_D161_Q1.0840.99
64_E68_D1.0790.99
129_D133_E1.0760.99
87_E123_D1.0750.99
141_L144_E1.0750.99
159_E166_T1.0740.99
110_F171_F1.0680.99
140_F150_Y1.0660.99
23_Y30_K1.0630.99
112_Y118_Y1.0590.99
147_I152_P1.0580.99
53_I59_P1.0570.99
72_E95_E1.0520.99
78_I84_D1.0510.99
42_S45_F1.0490.99
93_L108_L1.0380.99
31_R68_D1.0270.99
144_E148_P1.0180.99
80_H88_I1.0080.98
157_L161_Q1.0060.98
86_Y124_F1.0030.98
109_K169_E1.0000.98
160_K163_Y0.9920.98
35_M67_G0.9920.98
35_M70_W0.9890.98
29_L36_L0.9870.98
171_F175_V0.9850.98
29_L32_V0.9840.98
69_Y91_E0.9830.98
133_E136_E0.9670.98
103_L107_L0.9650.98
83_E118_Y0.9620.98
100_D103_L0.9520.98
5_Y11_P0.9500.98
106_E171_F0.9450.98
140_F146_E0.9390.98
33_E60_F0.9190.97
97_L100_D0.9190.97
91_E95_E0.9100.97
70_W76_F0.9080.97
31_R76_F0.9020.97
157_L165_H0.9020.97
81_S84_D0.8940.97
130_D137_I0.8840.97
72_E96_R0.8820.96
159_E163_Y0.8790.96
105_R109_K0.8660.96
152_P155_E0.8650.96
69_Y88_I0.8550.96
138_R163_Y0.8540.96
103_L173_F0.8480.96
50_E54_K0.8390.95
150_Y154_Y0.8320.95
129_D132_E0.8290.95
84_D88_I0.8270.95
69_Y73_K0.8240.95
102_E105_R0.8240.95
101_L105_R0.8230.95
48_T93_L0.8170.95
75_Y91_E0.8150.95
70_W75_Y0.8010.94
141_L168_I0.7950.94
47_H107_L0.7950.94
86_Y112_Y0.7940.94
137_I141_L0.7930.94
138_R160_K0.7930.94
8_M16_L0.7850.93
112_Y125_L0.7830.93
139_E143_N0.7750.93
70_W80_H0.7750.93
113_L119_K0.7740.93
158_D163_Y0.7670.93
134_K138_R0.7610.92
90_L94_E0.7580.92
131_K134_K0.7500.92
69_Y75_Y0.7500.92
38_K80_H0.7450.91
44_R116_E0.7440.91
138_R141_L0.7440.91
147_I162_L0.7370.91
135_E142_K0.7360.91
70_W88_I0.7360.91
132_E136_E0.7310.91
22_S26_I0.7290.91
40_Y63_F0.7250.90
51_Y100_D0.7220.90
135_E139_E0.7200.90
109_K125_L0.7150.90
163_Y166_T0.7140.90
138_R147_I0.7070.89
139_E142_K0.7060.89
163_Y167_H0.7010.89
5_Y124_F0.7000.89
97_L101_L0.6990.89
137_I140_F0.6960.88
97_L104_L0.6930.88
51_Y93_L0.6780.87
116_E122_P0.6720.87
23_Y92_F0.6630.86
154_Y162_L0.6570.85
130_D134_K0.6530.85
69_Y95_E0.6510.85
131_K143_N0.6430.84
32_V76_F0.6400.84
137_I168_I0.6400.84
23_Y35_M0.6370.84
43_G84_D0.6360.84
148_P154_Y0.6340.83
151_L165_H0.6340.83
39_Y66_L0.6330.83
82_L115_R0.6320.83
55_K65_E0.6310.83
136_E139_E0.6300.83
9_D63_F0.6300.83
159_E162_L0.6290.83
148_P155_E0.6280.83
106_E173_F0.6260.83
90_L101_L0.6260.83
17_S24_E0.6260.83
160_K164_K0.6250.82
93_L100_D0.6240.82
21_L29_L0.6210.82
51_Y104_L0.6170.82
27_L31_R0.6170.82
3_Y19_K0.6130.81
49_L53_I0.6110.81
161_Q166_T0.6100.81
81_S112_Y0.6070.81
48_T89_L0.6070.81
74_G77_R0.6060.80
94_E105_R0.6050.80
145_E148_P0.6040.80
56_F92_F0.6020.80
26_I36_L0.6000.80
39_Y70_W0.6000.80
48_T108_L0.5920.79
132_E135_E0.5890.79
52_L56_F0.5870.78
112_Y116_E0.5860.78
147_I151_L0.5850.78
15_V26_I0.5850.78
99_E106_E0.5840.78
147_I150_Y0.5830.78
55_K104_L0.5810.78
167_H171_F0.5800.78
128_E133_E0.5780.77
18_T21_L0.5720.77
142_K159_E0.5700.76
65_E68_D0.5650.76
17_S26_I0.5620.75
27_L30_K0.5610.75
65_E73_K0.5610.75
61_D65_E0.5610.75
159_E170_V0.5590.75
162_L168_I0.5580.75
109_K121_R0.5560.75
172_S175_V0.5540.74
59_P62_F0.5530.74
158_D169_E0.5520.74
109_K113_L0.5490.74
33_E36_L0.5480.74
10_Y17_S0.5470.73
133_E170_V0.5460.73
118_Y121_R0.5430.73
149_K171_F0.5430.73
127_R130_D0.5410.73
44_R119_K0.5350.72
65_E97_L0.5340.72
39_Y119_K0.5280.71
129_D141_L0.5250.70
116_E121_R0.5240.70
56_F63_F0.5240.70
7_Y148_P0.5200.70
34_E66_L0.5190.69
113_L167_H0.5190.69
91_E94_E0.5190.69
147_I154_Y0.5180.69
131_K136_E0.5160.69
149_K152_P0.5160.69
63_F78_I0.5140.69
106_E110_F0.5130.69
55_K101_L0.5070.68
83_E120_P0.5070.68
158_D166_T0.5050.67
51_Y103_L0.5040.67
37_E63_F0.5040.67
24_E27_L0.5030.67
34_E80_H0.5000.67
27_L34_E0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ercA 1 0.0745 21.7 0.933 Contact Map
2e9xA 1 0.2979 4.6 0.951 Contact Map
3cl6A 3 0.5053 4.5 0.951 Contact Map
3f2kA 1 0.4309 4.3 0.951 Contact Map
4mdaA 1 0.4362 4.2 0.951 Contact Map
4i43B 1 0.9043 3.5 0.953 Contact Map
3s6oA 3 0.4947 3.5 0.953 Contact Map
4jrbA 1 0.8404 3.2 0.954 Contact Map
2xpnB 1 0.0479 3.1 0.955 Contact Map
4jbuA 1 0.4415 2.5 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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