GREMLIN Database
Virulence_RhuM - Virulence protein RhuM family
PFAM: PF13310 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 252 (250)
Sequences: 8454 (3587)
Seq/√Len: 226.9
META: 0.898

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_R7_R6.7761.00
3_V8_T6.4591.00
231_H235_K4.1851.00
64_D84_R3.1371.00
134_H142_E3.1071.00
34_Y49_T2.8761.00
51_R61_V2.7241.00
186_S190_D2.6541.00
63_D66_R2.5531.00
5_K22_K2.5001.00
79_D98_K2.4861.00
179_K197_E2.4211.00
5_K20_N2.2981.00
144_A151_M2.2781.00
194_L220_R2.1211.00
213_A216_K2.1101.00
40_R43_Q2.0781.00
76_D94_R2.0641.00
163_K239_E2.0601.00
198_R220_R2.0551.00
2_T9_V2.0291.00
175_E179_K1.9311.00
46_I50_Q1.9001.00
27_D53_K1.8981.00
117_K121_A1.8621.00
12_E19_R1.8491.00
167_S239_E1.8401.00
53_K57_I1.8361.00
241_E244_K1.8351.00
58_K80_E1.8101.00
145_D148_K1.7941.00
114_E118_E1.7771.00
187_A191_F1.6911.00
107_I201_P1.6791.00
167_S235_K1.6631.00
141_Y237_K1.6591.00
7_R18_T1.6501.00
10_A19_R1.6381.00
11_A16_E1.6331.00
132_H139_I1.6021.00
180_E197_E1.5861.00
235_K239_E1.5851.00
246_R249_D1.5621.00
4_R8_T1.5361.00
205_K209_E1.4951.00
43_Q46_I1.4891.00
103_Y116_T1.4741.00
191_F195_Q1.4681.00
3_V7_R1.4501.00
8_T23_F1.4441.00
69_N72_A1.4441.00
183_R194_L1.4411.00
10_A14_K1.4391.00
9_V12_E1.4321.00
128_H169_A1.4291.00
137_A231_H1.4221.00
180_E198_R1.4211.00
11_A14_K1.4121.00
232_E236_E1.4091.00
12_E17_V1.3991.00
83_E179_K1.3971.00
4_R18_T1.3951.00
107_I203_T1.3771.00
146_A244_K1.3761.00
213_A219_E1.3591.00
210_K219_E1.3331.00
176_D197_E1.3301.00
3_V22_K1.3281.00
31_S39_K1.3281.00
126_K212_D1.3231.00
86_R183_R1.3191.00
8_T22_K1.3161.00
62_M81_L1.3151.00
7_R20_N1.3101.00
187_A218_N1.3091.00
37_N41_A1.3081.00
2_T12_E1.3061.00
202_M206_D1.3001.00
6_F23_F1.2811.00
12_E15_R1.2801.00
183_R197_E1.2761.00
166_V239_E1.2621.00
191_F217_F1.2611.00
180_E194_L1.2591.00
115_I118_E1.2541.00
42_T46_I1.2481.00
187_A190_D1.2461.00
28_A32_V1.2351.00
4_R20_N1.2331.00
62_M84_R1.2321.00
14_K19_R1.2311.00
118_E226_A1.2311.00
191_F210_K1.2291.00
28_A37_N1.2261.00
68_K87_D1.1971.00
210_K213_A1.1901.00
236_E240_S1.1871.00
113_S116_T1.1861.00
118_E122_T1.1851.00
90_A182_N1.1721.00
150_N156_W1.1711.00
157_K164_S1.1621.00
87_D182_N1.1591.00
15_R19_R1.1451.00
118_E121_A1.1401.00
237_K241_E1.1381.00
163_K243_E1.1041.00
54_E58_K1.1031.00
51_R55_Y1.1011.00
133_G221_E1.0911.00
10_A17_V1.0851.00
2_T10_A1.0801.00
195_Q200_I1.0791.00
8_T21_V1.0751.00
86_R193_E1.0661.00
179_K183_R1.0661.00
203_T206_D1.0601.00
213_A217_F1.0571.00
234_A238_A1.0491.00
60_F84_R1.0491.00
191_F218_N1.0411.00
209_E213_A1.0341.00
233_Q236_E1.0291.00
115_I208_I1.0261.00
194_L198_R1.0241.00
93_R97_Q1.0131.00
93_R100_T1.0091.00
10_A21_V1.0031.00
162_R165_D0.9881.00
10_A15_R0.9881.00
184_I187_A0.9801.00
9_V14_K0.9791.00
122_T208_I0.9781.00
9_V19_R0.9771.00
28_A41_A0.9741.00
7_R22_K0.9641.00
55_Y61_V0.9631.00
65_E157_K0.9611.00
9_V17_V0.9521.00
87_D90_A0.9501.00
195_Q210_K0.9431.00
208_I212_D0.9391.00
60_F64_D0.9391.00
156_W161_I0.9361.00
198_R219_E0.9321.00
146_A241_E0.9211.00
225_D228_K0.9181.00
195_Q202_M0.9181.00
243_E246_R0.9171.00
194_L218_N0.9130.99
206_D209_E0.9130.99
2_T19_R0.9110.99
85_I196_A0.9080.99
4_R22_K0.9070.99
247_K250_K0.9050.99
131_I180_E0.9040.99
95_F189_L0.8980.99
83_E164_S0.8950.99
6_F37_N0.8940.99
14_K17_V0.8920.99
232_E235_K0.8910.99
163_K167_S0.8910.99
67_L94_R0.8900.99
65_E68_K0.8840.99
141_Y229_I0.8820.99
66_R72_A0.8780.99
210_K214_F0.8770.99
48_A52_L0.8750.99
80_E157_K0.8690.99
176_D199_R0.8670.99
9_V15_R0.8640.99
11_A19_R0.8630.99
32_V36_V0.8590.99
188_Y195_Q0.8550.99
233_Q237_K0.8530.99
31_S37_N0.8510.99
200_I219_E0.8490.99
195_Q219_E0.8480.99
17_V20_N0.8470.99
35_R42_T0.8440.99
97_Q120_F0.8430.99
153_L166_V0.8400.99
210_K217_F0.8390.99
75_K199_R0.8370.99
147_E248_Q0.8280.99
176_D180_E0.8250.99
240_S244_K0.8210.99
143_R177_E0.8200.99
2_T17_V0.8170.99
30_I37_N0.8160.99
30_I49_T0.8110.99
90_A186_S0.8070.99
187_A214_F0.8060.99
166_V238_A0.8060.99
39_K43_Q0.7970.99
2_T14_K0.7960.99
153_L156_W0.7890.99
183_R187_A0.7890.99
128_H132_H0.7860.98
122_T226_A0.7860.98
158_G162_R0.7860.98
114_E117_K0.7670.98
2_T15_R0.7650.98
36_V41_A0.7630.98
110_D115_I0.7610.98
183_R190_D0.7590.98
187_A217_F0.7570.98
46_I53_K0.7520.98
64_D68_K0.7470.98
60_F80_E0.7330.98
246_R250_K0.7260.97
179_K182_N0.7250.97
236_E239_E0.7230.97
38_S52_L0.7220.97
215_L222_I0.7110.97
3_V21_V0.7080.97
39_K113_S0.7070.97
54_E84_R0.7040.97
19_R22_K0.7020.97
118_E208_I0.6980.97
157_K165_D0.6980.97
62_M67_L0.6970.97
115_I205_K0.6970.97
155_T159_A0.6950.97
187_A194_L0.6930.97
42_T49_T0.6890.97
105_T120_F0.6870.96
189_L207_W0.6840.96
30_I42_T0.6830.96
3_V10_A0.6790.96
70_G73_G0.6780.96
134_H143_R0.6780.96
103_Y211_L0.6770.96
50_Q53_K0.6770.96
95_F98_K0.6740.96
154_T174_N0.6720.96
36_V40_R0.6690.96
6_F20_N0.6610.96
12_E21_V0.6600.96
97_Q101_D0.6590.96
111_P116_T0.6580.96
12_E16_E0.6580.96
219_E222_I0.6580.96
125_N136_A0.6560.95
199_R219_E0.6550.95
17_V21_V0.6520.95
57_I61_V0.6510.95
4_R21_V0.6500.95
13_G17_V0.6500.95
217_F220_R0.6470.95
103_Y204_M0.6470.95
18_T21_V0.6440.95
212_D216_K0.6440.95
155_T165_D0.6430.95
195_Q218_N0.6410.95
129_Y225_D0.6390.95
121_A137_A0.6390.95
59_G152_G0.6370.95
1_S14_K0.6360.95
51_R57_I0.6350.95
214_F217_F0.6330.94
97_Q100_T0.6320.94
67_L74_G0.6320.94
94_R97_Q0.6310.94
134_H139_I0.6310.94
96_Y127_L0.6300.94
90_A178_L0.6300.94
25_N53_K0.6290.94
17_V22_K0.6290.94
192_A207_W0.6270.94
49_T53_K0.6260.94
55_Y63_D0.6260.94
161_I165_D0.6260.94
32_V41_A0.6260.94
196_A202_M0.6250.94
96_Y129_Y0.6250.94
147_E244_K0.6210.94
63_D72_A0.6210.94
54_E61_V0.6170.94
9_V21_V0.6170.94
30_I56_I0.6160.94
87_D162_R0.6080.93
137_A235_K0.6070.93
2_T21_V0.6030.93
93_R101_D0.6030.93
187_A210_K0.6010.93
28_A40_R0.5990.93
15_R18_T0.5990.93
37_N40_R0.5990.93
239_E243_E0.5980.93
180_E220_R0.5970.93
33_G152_G0.5970.93
6_F18_T0.5960.93
182_N186_S0.5950.92
103_Y123_V0.5940.92
230_S233_Q0.5930.92
32_V40_R0.5930.92
51_R56_I0.5920.92
183_R193_E0.5900.92
86_R186_S0.5890.92
209_E216_K0.5880.92
5_K8_T0.5840.92
2_T11_A0.5830.92
10_A16_E0.5820.92
46_I49_T0.5800.91
143_R154_T0.5800.91
136_A169_A0.5780.91
27_D31_S0.5780.91
27_D34_Y0.5770.91
16_E19_R0.5770.91
30_I46_I0.5760.91
237_K240_S0.5730.91
127_L131_I0.5690.91
5_K37_N0.5690.91
180_E184_I0.5680.91
167_S231_H0.5660.90
140_I231_H0.5650.90
58_K76_D0.5640.90
231_H234_A0.5630.90
244_K247_K0.5610.90
6_F41_A0.5590.90
122_T212_D0.5590.90
100_T104_A0.5590.90
225_D233_Q0.5580.90
240_S243_E0.5570.90
110_D113_S0.5560.90
18_T22_K0.5530.89
33_G59_G0.5480.89
56_I72_A0.5470.89
102_I105_T0.5460.89
123_V211_L0.5450.89
39_K42_T0.5450.89
144_A237_K0.5440.89
84_R175_E0.5410.88
80_E84_R0.5410.88
54_E64_D0.5390.88
15_R22_K0.5380.88
82_L186_S0.5370.88
9_V16_E0.5340.88
183_R186_S0.5340.88
76_D80_E0.5330.88
238_A241_E0.5330.88
214_F218_N0.5320.88
215_L218_N0.5310.88
166_V235_K0.5300.87
79_D197_E0.5300.87
125_N169_A0.5290.87
202_M207_W0.5270.87
69_N73_G0.5260.87
127_L181_L0.5250.87
8_T11_A0.5250.87
65_E69_N0.5220.87
121_A226_A0.5220.87
188_Y207_W0.5210.87
183_R214_F0.5200.86
140_I238_A0.5190.86
41_A51_R0.5190.86
150_N154_T0.5180.86
32_V37_N0.5170.86
3_V6_F0.5160.86
11_A18_T0.5150.86
96_Y106_S0.5140.86
214_F219_E0.5140.86
245_Y249_D0.5140.86
50_Q61_V0.5110.85
27_D46_I0.5100.85
112_K117_K0.5080.85
12_E18_T0.5070.85
121_A231_H0.5060.85
210_K218_N0.5060.85
53_K56_I0.5050.85
221_E224_T0.5050.85
87_D246_R0.5040.85
15_R21_V0.5030.85
187_A195_Q0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fhmA 1 0.3452 24 0.971 Contact Map
4hi1A 3 0.3373 16.2 0.973 Contact Map
2gv1A 1 0.3492 15.2 0.974 Contact Map
1ulrA 1 0.3333 14 0.974 Contact Map
1w2iA 2 0.3413 11.9 0.975 Contact Map
2bjdA 1 0.3452 11.6 0.975 Contact Map
2vh7A 1 0.3611 11.4 0.975 Contact Map
1gxuA 5 0.3452 10.4 0.976 Contact Map
1apsA 1 0.373 8.8 0.976 Contact Map
1wpiA 1 0.4643 8.1 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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