GREMLIN Database
Telomere_Sde2_2 - Telomere stability C-terminal
PFAM: PF13297 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 60 (60)
Sequences: 650 (461)
Seq/√Len: 59.5
META: 0.602

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_A26_A3.8021.00
37_E40_E2.9381.00
13_E36_Q2.7841.00
17_L35_L2.4851.00
2_D5_A2.3601.00
7_S11_E1.9981.00
29_L45_V1.8981.00
49_P52_E1.7730.99
48_L52_E1.6540.99
16_G35_L1.6440.99
50_L53_L1.6380.99
27_L45_V1.5790.99
43_F46_K1.4680.98
48_L53_L1.4310.97
19_R26_A1.4290.97
45_V53_L1.3730.97
53_L57_L1.3560.96
44_S57_L1.3410.96
25_M31_C1.3200.96
21_K31_C1.3140.96
9_A13_E1.2820.95
10_E36_Q1.2210.93
53_L58_F1.1700.92
3_L12_L1.1630.92
44_S47_G1.1610.92
10_E13_E1.1560.91
55_K58_F1.1500.91
1_L19_R1.1480.91
45_V50_L1.0810.88
8_S11_E1.0750.88
20_L35_L1.0060.85
28_G58_F0.9820.83
44_S53_L0.9460.81
18_D21_K0.9350.80
6_F15_L0.9250.79
50_L58_F0.9050.78
18_D31_C0.9000.77
36_Q40_E0.8940.77
16_G19_R0.8570.74
19_R23_A0.8550.74
18_D22_S0.8400.72
6_F9_A0.8120.70
19_R22_S0.8090.69
45_V48_L0.8080.69
4_D7_S0.7890.67
12_L39_A0.7750.66
17_L55_K0.7510.64
4_D47_G0.7370.62
17_L20_L0.7210.60
49_P53_L0.7060.59
54_P57_L0.7010.58
26_A34_T0.6950.58
4_D46_K0.6910.57
19_R31_C0.6830.56
40_E59_A0.6770.56
1_L15_L0.6690.55
45_V57_L0.6600.54
33_G41_R0.6550.53
23_A27_L0.6520.53
11_E14_A0.6440.52
44_S50_L0.6430.52
5_A11_E0.6420.52
34_T38_R0.6410.52
9_A36_Q0.6300.50
12_L29_L0.6250.50
4_D22_S0.6240.50
25_M60_K0.6150.49
29_L59_A0.6110.48
32_G38_R0.6020.47
48_L57_L0.6010.47
3_L23_A0.6000.47
22_S25_M0.5950.47
44_S48_L0.5870.46
2_D28_G0.5860.46
17_L38_R0.5860.46
52_E57_L0.5640.43
31_C37_E0.5570.42
30_K38_R0.5560.42
7_S10_E0.5410.41
29_L58_F0.5400.41
15_L35_L0.5350.40
40_E52_E0.5270.39
14_A22_S0.5240.39
37_E54_P0.5230.39
8_S43_F0.5210.38
29_L46_K0.5200.38
18_D38_R0.5160.38
11_E20_L0.5080.37
15_L19_R0.5070.37
42_L46_K0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kvuA 1 0.9833 84.4 0.787 Contact Map
1h1jS 1 0.6833 83.1 0.791 Contact Map
1jjrA 1 0.2 78.1 0.801 Contact Map
1jeyA 1 0 68.3 0.815 Contact Map
2rnnA 1 1 67.3 0.817 Contact Map
1zrjA 1 0.8333 66.2 0.818 Contact Map
2do1A 1 0.9167 63.2 0.821 Contact Map
4dgwA 1 0.8333 32.4 0.852 Contact Map
4rxiA 1 0.5667 22.8 0.863 Contact Map
4z3xA 2 0.55 16.3 0.871 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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