GREMLIN Database
NfrA_C - Bacteriophage N adsorption protein A C-term
PFAM: PF13283 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 173 (163)
Sequences: 515 (397)
Seq/√Len: 31.1
META: 0.744

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_S105_T5.4771.00
139_R148_S3.8821.00
64_S93_R3.8581.00
31_R44_W3.4951.00
141_D144_D3.1751.00
29_A46_L2.7401.00
66_W91_Q2.6041.00
45_L77_Y2.5921.00
106_L134_L2.4970.99
12_G30_E2.4430.99
45_L75_A2.4240.99
111_V130_P2.2070.99
24_N51_S2.1660.98
139_R147_R2.1660.98
76_Y83_T2.1400.98
68_W91_Q2.0670.98
49_S73_D2.0370.98
153_S157_R1.9790.97
27_L48_A1.9460.97
66_W93_R1.9390.97
46_L78_L1.8630.96
67_Y107_T1.8150.95
23_Q50_Y1.7810.95
11_G33_F1.7410.94
109_H115_R1.6650.93
36_G39_A1.6530.92
70_L74_A1.6480.92
20_L25_L1.6100.91
51_S86_T1.6050.91
144_D147_R1.5720.90
65_W107_T1.5530.90
58_L146_P1.5450.89
60_P140_E1.5150.89
11_G35_L1.4840.87
30_E47_R1.4680.87
66_W77_Y1.4230.85
141_D147_R1.4050.84
50_Y70_L1.4000.84
30_E86_T1.3840.83
15_L132_V1.3830.83
13_V33_F1.3480.82
88_E111_V1.3400.81
7_D41_D1.3370.81
88_E109_H1.3370.81
45_L73_D1.3290.81
34_K39_A1.3270.81
10_Q32_L1.3240.81
109_H155_Q1.3230.81
8_S36_G1.3180.80
49_S149_Y1.3170.80
48_A73_D1.3160.80
68_W89_A1.3110.80
32_L39_A1.2780.78
46_L154_L1.2760.78
94_S107_T1.2760.78
135_R151_D1.2470.76
55_G146_P1.2390.76
98_D101_S1.2360.76
37_D40_R1.2300.75
52_G109_H1.2270.75
34_K41_D1.2080.74
47_R73_D1.2000.74
159_R162_G1.1860.73
51_S75_A1.1620.71
52_G68_W1.1600.71
15_L93_R1.1500.70
72_A87_A1.1440.70
132_V154_L1.1420.70
15_L29_A1.1340.69
133_S151_D1.1290.69
141_D146_P1.0990.67
133_S153_S1.0940.66
47_R90_R1.0910.66
113_A157_R1.0710.65
41_D79_E1.0540.63
7_D37_D1.0540.63
137_W145_A1.0310.62
8_S38_N1.0240.61
8_S146_P1.0000.59
57_D137_W0.9990.59
26_V49_S0.9960.59
65_W137_W0.9790.58
26_V51_S0.9660.57
18_K143_Y0.9600.56
90_R151_D0.9490.55
25_L50_Y0.9330.54
136_Y154_L0.9260.53
140_E146_P0.9190.53
47_R71_Y0.9040.52
9_L46_L0.9000.51
68_W117_D0.8980.51
121_A150_L0.8960.51
157_R162_G0.8870.50
57_D145_A0.8850.50
18_K90_R0.8810.50
31_R79_E0.8770.49
49_S135_R0.8680.49
56_T67_Y0.8490.47
62_R154_L0.8440.47
31_R36_G0.8410.47
92_G133_S0.8410.47
151_D157_R0.8370.46
37_D63_P0.8330.46
11_G124_T0.8300.46
135_R149_Y0.8220.45
14_G19_P0.8200.45
97_L134_L0.8190.45
104_L136_Y0.8170.45
29_A82_Q0.8070.44
81_G87_A0.8070.44
6_S143_Y0.8070.44
71_Y109_H0.8020.43
102_D130_P0.8010.43
87_A110_L0.7880.42
63_P154_L0.7860.42
92_G151_D0.7860.42
45_L71_Y0.7790.42
34_K97_L0.7760.41
84_Y117_D0.7720.41
7_D33_F0.7700.41
63_P110_L0.7680.41
59_R62_R0.7680.41
81_G110_L0.7650.41
51_S105_T0.7640.40
22_D118_S0.7590.40
112_L167_E0.7500.39
58_L109_H0.7500.39
121_A142_R0.7420.39
77_Y143_Y0.7420.39
114_A142_R0.7400.39
72_A107_T0.7370.38
61_D96_R0.7350.38
29_A78_L0.7330.38
96_R104_L0.7300.38
110_L122_T0.7260.38
104_L135_R0.7240.37
49_S109_H0.7230.37
43_D51_S0.7220.37
77_Y84_Y0.7220.37
7_D140_E0.7130.37
90_R153_S0.7110.36
84_Y141_D0.7090.36
105_T137_W0.7090.36
22_D29_A0.7020.36
112_L160_L0.7000.36
43_D78_L0.6990.36
10_Q105_T0.6910.35
117_D125_A0.6910.35
116_Y127_G0.6890.35
96_R137_W0.6870.35
29_A48_A0.6830.34
88_E113_A0.6830.34
142_R164_D0.6830.34
106_L130_P0.6680.33
12_G73_D0.6680.33
159_R163_D0.6670.33
26_V72_A0.6650.33
138_F148_S0.6650.33
164_D167_E0.6620.33
105_T145_A0.6570.32
72_A79_E0.6500.32
40_R43_D0.6400.31
165_R168_G0.6370.31
58_L96_R0.6350.31
33_F41_D0.6340.31
13_V26_V0.6300.31
21_R41_D0.6280.30
8_S137_W0.6260.30
34_K118_S0.6250.30
85_A114_A0.6250.30
18_K45_L0.6220.30
35_L124_T0.6190.30
75_A133_S0.6170.30
74_A103_R0.6140.30
28_S40_R0.6140.30
130_P156_Y0.6120.29
154_L159_R0.6100.29
16_R25_L0.6080.29
100_I104_L0.6080.29
49_S87_A0.6070.29
123_R130_P0.6070.29
119_S132_V0.6070.29
88_E151_D0.6060.29
59_R145_A0.6050.29
71_Y132_V0.6040.29
7_D70_L0.6040.29
94_S137_W0.6020.29
58_L125_A0.6010.29
60_P63_P0.5960.28
97_L125_A0.5910.28
17_Y77_Y0.5910.28
68_W72_A0.5880.28
30_E75_A0.5870.28
27_L121_A0.5860.28
68_W109_H0.5850.28
114_A126_L0.5820.27
46_L66_W0.5820.27
145_A149_Y0.5800.27
88_E155_Q0.5780.27
105_T132_V0.5750.27
27_L136_Y0.5720.27
22_D38_N0.5660.26
140_E154_L0.5640.26
64_S152_L0.5630.26
22_D123_R0.5630.26
72_A85_A0.5620.26
32_L35_L0.5610.26
12_G23_Q0.5590.26
24_N135_R0.5570.26
9_L62_R0.5550.26
44_W127_G0.5550.26
13_V39_A0.5530.26
78_L119_S0.5520.26
17_Y62_R0.5520.26
31_R140_E0.5520.26
49_S106_L0.5480.25
58_L110_L0.5480.25
67_Y90_R0.5470.25
61_D141_D0.5410.25
13_V80_A0.5390.25
59_R96_R0.5390.25
108_P131_G0.5370.25
37_D133_S0.5310.24
51_S77_Y0.5310.24
19_P27_L0.5290.24
54_Y68_W0.5270.24
159_R166_A0.5270.24
80_A87_A0.5240.24
131_G157_R0.5220.24
116_Y156_Y0.5210.24
26_V116_Y0.5140.23
103_R140_E0.5140.23
59_R133_S0.5110.23
25_L168_G0.5110.23
57_D125_A0.5100.23
34_K37_D0.5100.23
83_T113_A0.5090.23
28_S47_R0.5090.23
40_R79_E0.5090.23
39_A124_T0.5070.23
50_Y55_G0.5030.23
125_A157_R0.5030.23
73_D77_Y0.5010.23
121_A126_L0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2x55A 1 0.6243 61.5 0.923 Contact Map
4e1sA 1 0.8786 35.2 0.934 Contact Map
4rl8A 3 0.9133 34.4 0.934 Contact Map
4e1tA 1 0.8613 27.3 0.938 Contact Map
4meeA 1 0.6936 23.1 0.94 Contact Map
2jmmA 1 0.3237 22.6 0.94 Contact Map
1ormA 1 0.289 19.6 0.942 Contact Map
3efmA 1 0.8439 16.9 0.944 Contact Map
1uynX 1 0.815 14.2 0.945 Contact Map
3sltA 1 0.8728 13 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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