GREMLIN Database
DUF4070 - Domain of unknown function (DUF4070)
PFAM: PF13282 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 141 (135)
Sequences: 11300 (7852)
Seq/√Len: 675.8
META: 0.96

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_R106_W3.4401.00
31_P34_E2.5641.00
88_W93_L2.5271.00
45_T51_A2.5191.00
5_R9_R2.4541.00
41_R45_T2.2741.00
81_R85_R2.2581.00
30_M38_G2.2521.00
33_E37_E2.2371.00
76_L79_D2.1781.00
111_R114_L2.0751.00
5_R8_K2.0721.00
50_K99_Y1.9631.00
58_T62_E1.9511.00
48_S51_A1.8741.00
14_L27_I1.8551.00
24_T28_P1.7621.00
8_K13_L1.7401.00
34_E37_E1.7241.00
91_G101_W1.7161.00
125_G129_R1.7001.00
106_W110_R1.6921.00
10_E29_K1.6851.00
17_G20_T1.6651.00
2_P5_R1.6591.00
51_A54_E1.6491.00
59_F63_Y1.6231.00
24_T32_R1.6061.00
86_S100_Y1.5741.00
89_R93_L1.5381.00
105_L109_R1.5151.00
32_R36_L1.5071.00
120_T124_Y1.4831.00
4_Y8_K1.4671.00
42_I46_I1.4491.00
107_T118_A1.4301.00
104_L119_I1.4051.00
30_M34_E1.3971.00
99_Y102_R1.3941.00
35_L38_G1.3841.00
54_E58_T1.3571.00
6_R10_E1.3091.00
77_L81_R1.2861.00
99_Y103_L1.2771.00
30_M35_L1.2771.00
130_K134_E1.2751.00
43_L132_A1.2441.00
14_L32_R1.2371.00
88_W92_I1.2281.00
68_K71_R1.2221.00
7_L26_F1.1961.00
87_I100_Y1.1911.00
70_P73_R1.1711.00
86_S123_I1.1671.00
53_Y122_A1.1471.00
4_Y13_L1.1381.00
40_R44_R1.1131.00
114_L117_L1.1061.00
37_E41_R1.0981.00
28_P32_R1.0951.00
115_F119_I1.0931.00
75_L79_D1.0781.00
78_R82_A1.0701.00
41_R44_R1.0691.00
130_K133_R1.0521.00
86_S90_L1.0261.00
80_L84_L1.0151.00
98_R102_R1.0111.00
103_L107_T1.0111.00
83_L87_I0.9971.00
69_R72_S0.9961.00
57_R102_R0.9951.00
84_L88_W0.9891.00
82_A86_S0.9741.00
79_D82_A0.9691.00
61_R106_W0.9681.00
42_I45_T0.9681.00
38_G42_I0.9601.00
58_T61_R0.9551.00
118_A122_A0.9551.00
54_E102_R0.9221.00
61_R110_R0.9221.00
105_L108_L0.9161.00
14_L26_F0.9141.00
18_D23_S0.9121.00
106_W109_R0.9121.00
36_L40_R0.9081.00
87_I92_I0.9031.00
83_L119_I0.8981.00
90_L94_G0.8971.00
129_R133_R0.8971.00
16_S20_T0.8881.00
16_S23_S0.8841.00
117_L120_T0.8831.00
57_R99_Y0.8801.00
103_L118_A0.8771.00
16_S19_N0.8751.00
104_L118_A0.8621.00
24_T35_L0.8581.00
96_E99_Y0.8491.00
37_E40_R0.8431.00
52_Y125_G0.8371.00
57_R61_R0.8371.00
106_W111_R0.8361.00
49_P96_E0.8351.00
85_R89_R0.8241.00
24_T36_L0.8191.00
129_R132_A0.8121.00
75_L80_L0.8071.00
116_P120_T0.8031.00
18_D21_D0.7991.00
2_P9_R0.7971.00
126_Y130_K0.7881.00
126_Y129_R0.7841.00
56_V103_L0.7791.00
28_P31_P0.7761.00
132_A135_V0.7751.00
20_T43_L0.7671.00
97_R100_Y0.7641.00
16_S21_D0.7591.00
78_R81_R0.7531.00
97_R101_W0.7501.00
52_Y128_F0.7461.00
56_V121_L0.7401.00
87_I90_L0.7361.00
3_L6_R0.7211.00
89_R92_I0.7161.00
85_R88_W0.7121.00
60_L118_A0.7081.00
82_A85_R0.7031.00
76_L81_R0.6881.00
53_Y96_E0.6811.00
124_Y131_F0.6791.00
124_Y128_F0.6781.00
7_L13_L0.6731.00
113_R116_P0.6711.00
119_I123_I0.6671.00
82_A123_I0.6641.00
52_Y56_V0.6641.00
57_R103_L0.6601.00
92_I97_R0.6571.00
101_W104_L0.6511.00
126_Y131_F0.6501.00
28_P35_L0.6401.00
43_L47_Y0.6331.00
88_W91_G0.6331.00
45_T48_S0.6301.00
52_Y121_L0.6281.00
63_Y114_L0.6281.00
38_G41_R0.6251.00
107_T110_R0.6221.00
128_F131_F0.6211.00
61_R109_R0.6171.00
95_K98_R0.6161.00
77_L80_L0.6091.00
96_E100_Y0.6081.00
13_L26_F0.6081.00
94_G97_R0.6041.00
53_Y103_L0.6021.00
117_L121_L0.5991.00
50_K98_R0.5971.00
54_E57_R0.5961.00
57_R107_T0.5961.00
22_G36_L0.5951.00
47_Y52_Y0.5951.00
8_K11_G0.5921.00
113_R117_L0.5831.00
117_L124_Y0.5801.00
20_T132_A0.5771.00
63_Y117_L0.5731.00
100_Y103_L0.5701.00
126_Y132_A0.5701.00
108_L112_P0.5681.00
121_L124_Y0.5611.00
39_Y43_L0.5601.00
50_K54_E0.5591.00
19_N23_S0.5591.00
125_G131_F0.5561.00
68_K72_S0.5551.00
75_L82_A0.5541.00
78_R85_R0.5531.00
60_L114_L0.5521.00
50_K102_R0.5501.00
76_L84_L0.5461.00
63_Y66_P0.5441.00
84_L87_I0.5421.00
123_I132_A0.5401.00
131_F135_V0.5351.00
69_R73_R0.5321.00
90_L93_L0.5301.00
90_L100_Y0.5281.00
86_S119_I0.5210.99
73_R79_D0.5200.99
107_T111_R0.5170.99
88_W97_R0.5150.99
10_E14_L0.5110.99
74_R78_R0.5090.99
79_D116_P0.5090.99
56_V59_F0.5080.99
22_G135_V0.5060.99
82_A91_G0.5000.99
79_D85_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4j8sA 1 0.8652 14.2 0.917 Contact Map
1kl9A 2 0.5887 7 0.928 Contact Map
1szqA 2 0.5603 6.2 0.929 Contact Map
4nfuA 1 0.9291 4.6 0.934 Contact Map
2ogfA 4 0.3617 3.9 0.936 Contact Map
2gtaA 4 0.6454 3.6 0.937 Contact Map
4b8bA 2 0.9574 3.5 0.937 Contact Map
3qwlA 1 0.5532 3.5 0.937 Contact Map
2ys8A 1 0.4894 3.4 0.937 Contact Map
2x6hA 2 0.461 3.3 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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