GREMLIN Database
WYL - WYL domain
PFAM: PF13280 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 172 (170)
Sequences: 68814 (53095)
Seq/√Len: 4072.2
META: 0.829

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_R33_E2.9931.00
33_E51_H2.7911.00
99_R130_R2.6871.00
142_A163_E2.6181.00
101_R128_S2.3441.00
97_E134_P2.3321.00
19_D29_E2.3311.00
17_R31_T2.2961.00
17_R29_E2.2141.00
99_R132_T2.2071.00
97_E132_T2.1691.00
101_R130_R2.1551.00
99_R156_E2.1451.00
124_L130_R2.1221.00
168_A171_A2.1201.00
14_R69_V2.0481.00
101_R153_E2.0341.00
19_D66_S2.0161.00
18_F32_V1.9881.00
15_R31_T1.9871.00
103_S151_D1.9631.00
32_V48_A1.9621.00
18_F64_I1.9521.00
8_E12_E1.9311.00
101_R155_L1.8401.00
15_R51_H1.8321.00
150_P167_R1.8121.00
142_A167_R1.8091.00
146_L167_R1.8081.00
96_V159_E1.6931.00
15_R72_E1.6691.00
6_L16_V1.6471.00
105_E151_D1.6031.00
17_R70_L1.6001.00
32_V46_L1.5991.00
165_R169_R1.5921.00
150_P170_R1.5791.00
21_R65_R1.5731.00
158_P162_E1.5681.00
17_R68_E1.5361.00
138_L163_E1.5321.00
5_T67_V1.3961.00
138_L159_E1.3861.00
163_E167_R1.3681.00
53_R57_R1.3661.00
144_W147_S1.3551.00
130_R155_L1.3321.00
153_E161_R1.3181.00
124_L128_S1.3171.00
31_T72_E1.3061.00
99_R155_L1.2971.00
50_D53_R1.2821.00
48_A59_F1.2751.00
106_A151_D1.2681.00
163_E166_E1.2661.00
161_R165_R1.2491.00
30_R50_D1.2471.00
35_Y56_I1.2451.00
19_D65_R1.2351.00
14_R71_D1.2251.00
33_E49_Y1.2111.00
21_R27_G1.2021.00
9_A69_V1.1921.00
142_A164_V1.1911.00
49_Y54_G1.1871.00
14_R73_R1.1741.00
166_E170_R1.1701.00
95_P134_P1.1701.00
2_V5_T1.1681.00
101_R124_L1.1591.00
31_T51_H1.1531.00
103_S128_S1.1491.00
8_E69_V1.1401.00
43_R60_R1.1371.00
50_D57_R1.1271.00
167_R170_R1.1261.00
33_E74_F1.1161.00
30_R59_F1.0861.00
31_T70_L1.0821.00
100_L145_L1.0741.00
18_F59_F1.0661.00
5_T69_V1.0581.00
158_P161_R1.0531.00
154_V164_V1.0491.00
102_F110_V1.0401.00
125_D128_S1.0341.00
5_T8_E1.0221.00
162_E166_E1.0131.00
142_A160_L1.0081.00
139_E163_E1.0071.00
15_R70_L1.0071.00
111_R123_E1.0041.00
102_F152_V1.0031.00
80_D83_A0.9851.00
45_Y60_R0.9831.00
34_P46_L0.9771.00
100_L152_V0.9711.00
36_G81_L0.9681.00
43_R62_D0.9561.00
12_E69_V0.9481.00
138_L142_A0.9421.00
119_Q132_T0.9381.00
6_L61_L0.9241.00
27_G65_R0.9211.00
19_D27_G0.9191.00
13_R74_F0.9181.00
13_R76_R0.9081.00
36_G47_V0.8991.00
45_Y58_T0.8821.00
103_S106_A0.8781.00
162_E165_R0.8751.00
18_F67_V0.8741.00
156_E159_E0.8721.00
146_L164_V0.8601.00
88_S93_E0.8591.00
139_E143_R0.8561.00
107_A111_R0.8541.00
145_L164_V0.8411.00
49_Y53_R0.8391.00
9_A16_V0.8391.00
97_E156_E0.8381.00
115_W118_Q0.8281.00
47_V58_T0.8281.00
88_S91_V0.8141.00
96_V138_L0.8071.00
148_F152_V0.8051.00
22_S26_E0.8051.00
47_V84_Y0.8021.00
89_F92_F0.7931.00
116_P119_Q0.7931.00
166_E169_R0.7901.00
139_E142_A0.7871.00
96_V137_D0.7851.00
39_F44_W0.7841.00
108_R111_R0.7791.00
95_P136_A0.7771.00
164_V168_A0.7741.00
88_S92_F0.7711.00
121_E130_R0.7651.00
85_L88_S0.7611.00
6_L64_I0.7601.00
107_A129_V0.7541.00
98_V141_L0.7541.00
36_G79_F0.7541.00
135_V141_L0.7501.00
120_I132_T0.7491.00
154_V161_R0.7461.00
38_V47_V0.7451.00
105_E108_R0.7421.00
87_R91_V0.7411.00
25_G28_T0.7401.00
106_A109_Y0.7361.00
79_F84_Y0.7341.00
102_F148_F0.7341.00
22_S25_G0.7341.00
58_T84_Y0.7311.00
145_L152_V0.7311.00
21_R25_G0.7301.00
137_D142_A0.7301.00
24_R27_G0.7271.00
106_A148_F0.7231.00
104_P127_G0.7221.00
14_R70_L0.7101.00
87_R90_G0.7101.00
138_L160_L0.7091.00
109_Y113_R0.7071.00
146_L168_A0.7061.00
7_A11_R0.7041.00
2_V67_V0.7001.00
22_S28_T0.6961.00
8_E14_R0.6911.00
83_A87_R0.6911.00
35_Y49_Y0.6891.00
6_L46_L0.6831.00
50_D59_F0.6821.00
98_V135_V0.6811.00
122_E130_R0.6771.00
102_F106_A0.6761.00
70_L73_R0.6691.00
31_T52_D0.6671.00
118_Q121_E0.6671.00
91_V94_G0.6591.00
83_A86_A0.6571.00
128_S153_E0.6551.00
24_R28_T0.6541.00
124_L127_G0.6531.00
37_L61_L0.6531.00
90_G93_E0.6471.00
104_P128_S0.6451.00
117_S120_I0.6411.00
46_L64_I0.6411.00
121_E132_T0.6391.00
119_Q122_E0.6381.00
121_E124_L0.6381.00
35_Y77_P0.6351.00
82_A86_A0.6331.00
103_S153_E0.6331.00
81_L85_L0.6271.00
16_V32_V0.6221.00
32_V59_F0.6141.00
49_Y55_D0.6111.00
20_Y59_F0.6081.00
165_R168_A0.5991.00
56_I84_Y0.5981.00
63_R112_E0.5931.00
140_E144_W0.5901.00
87_R95_P0.5881.00
35_Y74_F0.5851.00
118_Q122_E0.5841.00
144_W148_F0.5811.00
159_E163_E0.5801.00
3_L7_A0.5801.00
104_P129_V0.5781.00
116_P120_I0.5781.00
21_R24_R0.5771.00
96_V135_V0.5731.00
47_V56_I0.5711.00
30_R57_R0.5711.00
4_E8_E0.5691.00
10_I37_L0.5651.00
84_Y93_E0.5651.00
98_V160_L0.5641.00
104_P108_R0.5591.00
64_I67_V0.5581.00
84_Y87_R0.5571.00
122_E125_D0.5561.00
164_V167_R0.5551.00
100_L133_L0.5551.00
138_L141_L0.5531.00
82_A85_L0.5441.00
23_A63_R0.5381.00
143_R147_S0.5371.00
4_E7_A0.5371.00
21_R26_E0.5361.00
39_F42_G0.5361.00
104_P107_A0.5331.00
159_E162_E0.5321.00
70_L74_F0.5311.00
10_I13_R0.5301.00
102_F107_A0.5281.00
20_Y60_R0.5231.00
49_Y56_I0.5201.00
137_D159_E0.5201.00
18_F48_A0.5191.00
111_R122_E0.5161.00
29_E66_S0.5151.00
145_L154_V0.5141.00
139_E167_R0.5121.00
137_D140_E0.5111.00
114_P117_S0.5091.00
96_V99_R0.5071.00
154_V160_L0.5051.00
76_R79_F0.5041.00
10_I34_P0.5001.00
105_E109_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sg5A 1 0.4302 29.5 0.889 Contact Map
3iarA 1 0.4884 3.7 0.927 Contact Map
1jr3A 3 0.9826 2.8 0.931 Contact Map
2e9xB 1 0.4535 2.7 0.932 Contact Map
1rblM 3 0.4767 2.6 0.933 Contact Map
1wddS 3 0.4535 2.5 0.933 Contact Map
4g1iA 1 0.3779 2.4 0.934 Contact Map
4k0mC 1 0.5116 2.3 0.935 Contact Map
1svdM 3 0.4709 2.2 0.935 Contact Map
2e52A 2 0.407 2.1 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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