GREMLIN Database
DUF4065 - Protein of unknown function (DUF4065)
PFAM: PF13274 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 114 (113)
Sequences: 20668 (18309)
Seq/√Len: 1722.3
META: 0.908

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_Y34_V3.2621.00
12_H16_Y2.9181.00
98_L102_E2.8531.00
30_Y104_S2.6511.00
81_S84_E2.4531.00
8_A20_L2.3511.00
8_A88_L2.2291.00
28_W33_V2.1791.00
32_P107_T2.0191.00
12_H87_L2.0101.00
101_K104_S2.0031.00
26_E35_P1.8751.00
98_L106_L1.8621.00
9_D21_T1.8351.00
100_A104_S1.8321.00
35_P39_D1.8271.00
80_L84_E1.7691.00
99_S102_E1.7551.00
10_F14_A1.6401.00
4_L95_Y1.6021.00
9_D25_Y1.5951.00
9_D19_P1.5711.00
7_Y106_L1.5711.00
3_K108_H1.5681.00
87_L91_V1.5581.00
90_E94_K1.5401.00
38_Y42_K1.5021.00
11_W90_E1.4741.00
95_Y106_L1.4661.00
11_W15_K1.4611.00
23_D36_E1.4271.00
95_Y98_L1.3701.00
16_Y83_E1.3481.00
15_K90_E1.3431.00
15_K87_L1.3291.00
12_H20_L1.3281.00
101_K105_D1.3111.00
11_W14_A1.2921.00
11_W95_Y1.2691.00
7_Y110_E1.2691.00
5_L37_L1.2351.00
92_I96_G1.2301.00
19_P22_G1.2211.00
16_Y87_L1.1941.00
11_W94_K1.1861.00
89_D92_I1.1311.00
76_D79_D1.1251.00
67_Y70_E1.1211.00
10_F112_P1.0821.00
85_L89_D1.0751.00
39_D42_K1.0721.00
11_W87_L1.0631.00
53_E57_W1.0121.00
37_L45_G1.0041.00
84_E87_L1.0041.00
102_E106_L0.9861.00
20_L84_E0.9681.00
71_P75_P0.9571.00
42_K45_G0.9521.00
80_L85_L0.9441.00
68_E71_P0.9371.00
95_Y103_L0.9241.00
80_L88_L0.9171.00
66_Y69_V0.9141.00
86_E90_E0.9031.00
12_H84_E0.8961.00
23_D34_V0.8951.00
21_T25_Y0.8951.00
64_K67_Y0.8861.00
75_P78_S0.8811.00
21_T34_V0.8701.00
36_E39_D0.8651.00
4_L91_V0.8581.00
9_D20_L0.8521.00
45_G49_I0.8511.00
72_L75_P0.8511.00
8_A91_V0.8431.00
104_S108_H0.8331.00
7_Y107_T0.8291.00
44_Y47_N0.8191.00
71_P74_D0.8161.00
60_F63_K0.8121.00
10_F13_L0.8111.00
5_L34_V0.8111.00
7_Y91_V0.8101.00
87_L90_E0.8071.00
59_E63_K0.8061.00
18_R84_E0.7961.00
65_D68_E0.7911.00
37_L40_E0.7881.00
49_I53_E0.7811.00
51_I54_E0.7791.00
102_E105_D0.7771.00
105_D109_E0.7661.00
94_K98_L0.7501.00
63_K66_Y0.7501.00
6_Y10_F0.7431.00
9_D12_H0.7431.00
28_W35_P0.7401.00
33_V108_H0.7401.00
106_L109_E0.7371.00
9_D13_L0.7311.00
67_Y71_P0.7301.00
65_D70_E0.7231.00
12_H83_E0.7231.00
83_E87_L0.7181.00
69_V72_L0.7171.00
74_D77_L0.7141.00
13_L19_P0.7141.00
68_E72_L0.7141.00
2_Q5_L0.7111.00
30_Y101_K0.7071.00
37_L42_K0.7001.00
73_R77_L0.6981.00
2_Q38_Y0.6941.00
82_E85_L0.6931.00
41_I53_E0.6911.00
5_L25_Y0.6841.00
2_Q34_V0.6841.00
16_Y84_E0.6831.00
41_I44_Y0.6821.00
54_E57_W0.6821.00
36_E40_E0.6821.00
66_Y71_P0.6751.00
104_S107_T0.6701.00
37_L41_I0.6691.00
28_W38_Y0.6631.00
2_Q37_L0.6601.00
57_W60_F0.6591.00
82_E86_E0.6541.00
93_E96_G0.6541.00
6_Y112_P0.6461.00
40_E44_Y0.6451.00
73_R76_D0.6431.00
11_W91_V0.6351.00
63_K68_E0.6341.00
70_E73_R0.6301.00
51_I55_E0.6151.00
38_Y41_I0.6131.00
5_L8_A0.6041.00
59_E62_S0.5991.00
90_E93_E0.5981.00
89_D93_E0.5981.00
71_P76_D0.5931.00
96_G103_L0.5851.00
2_Q33_V0.5841.00
52_E57_W0.5831.00
63_K67_Y0.5831.00
84_E88_L0.5821.00
94_K106_L0.5801.00
86_E89_D0.5691.00
56_Y59_E0.5681.00
53_E56_Y0.5671.00
52_E56_Y0.5661.00
66_Y70_E0.5651.00
4_L96_G0.5631.00
5_L9_D0.5581.00
9_D34_V0.5441.00
2_Q7_Y0.5411.00
29_P33_V0.5361.00
62_S65_D0.5311.00
30_Y100_A0.5281.00
56_Y60_F0.5231.00
62_S66_Y0.5201.00
91_V95_Y0.5181.00
106_L110_E0.5121.00
33_V38_Y0.5071.00
69_V73_R0.5041.00
48_P52_E0.5001.00
77_L85_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mcaA 1 0 5.5 0.892 Contact Map
1fexA 1 0.3421 5.1 0.894 Contact Map
4gc8A 1 0.3158 4.9 0.894 Contact Map
1x46A 1 0.3596 4.7 0.896 Contact Map
3ctzA 2 0.9649 4.4 0.897 Contact Map
1xkrA 1 0.3333 4.3 0.898 Contact Map
2zetC 1 0.3509 4.1 0.899 Contact Map
4cc9B 1 0.2456 3.7 0.9 Contact Map
2k4bA 1 0.3158 3.4 0.902 Contact Map
1vw4S 1 0 3.4 0.903 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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