GREMLIN Database
DUF4064 - Protein of unknown function (DUF4064)
PFAM: PF13273 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 100 (99)
Sequences: 1222 (1016)
Seq/√Len: 102.1
META: 0.597

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_F10_I4.5661.00
2_R5_E3.2151.00
13_G76_A3.1441.00
10_I14_I3.0761.00
3_T7_V2.9641.00
73_I77_I2.7951.00
75_G86_A2.6501.00
9_G90_L2.3611.00
89_L93_A2.3451.00
86_A90_L2.0371.00
76_A79_I2.0151.00
88_I92_I1.9151.00
72_G90_L1.7591.00
16_G97_S1.7561.00
68_L96_L1.7131.00
85_L89_L1.7111.00
16_G69_S1.5481.00
71_L75_G1.5431.00
65_A97_S1.5251.00
16_G72_G1.5221.00
86_A93_A1.5011.00
15_L19_G1.4921.00
58_I62_G1.4431.00
75_G90_L1.4201.00
10_I13_G1.3941.00
7_V11_I1.3861.00
86_A89_L1.3801.00
5_E80_K1.3680.99
5_E79_I1.3470.99
93_A97_S1.2680.99
7_V14_I1.2550.99
41_Q45_E1.2500.99
23_A28_G1.2190.99
41_Q44_E1.1880.99
5_E81_K1.1750.98
72_G93_A1.1660.98
70_I74_V1.1580.98
37_E40_E1.0860.97
85_L88_I1.0810.97
22_F27_G1.0650.97
59_I63_I1.0480.97
83_P86_A1.0400.97
1_K5_E1.0370.97
89_L98_L1.0190.96
75_G79_I1.0050.96
20_G24_L1.0050.96
13_G16_G1.0010.96
39_Q46_P0.9900.95
1_K6_F0.9870.95
9_G13_G0.9480.94
20_G69_S0.9480.94
9_G77_I0.9320.94
36_E39_Q0.9230.93
40_E44_E0.8880.92
79_I94_G0.8800.92
55_G59_I0.8760.92
13_G73_I0.8750.91
87_G91_L0.8730.91
53_S63_I0.8720.91
10_I76_A0.8610.91
4_A81_K0.8490.90
83_P87_G0.8470.90
37_E41_Q0.8450.90
15_L18_L0.8400.90
39_Q44_E0.8370.90
39_Q42_M0.8350.89
42_M45_E0.8300.89
57_L67_I0.8280.89
38_L43_Q0.8200.89
47_A50_I0.8180.88
79_I86_A0.8160.88
72_G94_G0.8030.88
35_K39_Q0.7890.87
6_F86_A0.7830.86
94_G98_L0.7820.86
21_L25_F0.7620.85
28_G31_S0.7560.84
9_G94_G0.7520.84
35_K38_L0.7460.83
26_I30_G0.7340.82
5_E76_A0.7340.82
75_G80_K0.7340.82
79_I90_L0.7280.82
10_I72_G0.7260.82
67_I70_I0.7180.81
72_G75_G0.7100.80
78_L81_K0.7060.80
39_Q43_Q0.7060.80
10_I86_A0.7000.79
19_G23_A0.6980.79
90_L94_G0.6760.77
62_G68_L0.6740.77
69_S76_A0.6690.76
4_A11_I0.6600.75
21_L86_A0.6560.75
68_L71_L0.6560.75
4_A10_I0.6520.74
55_G58_I0.6510.74
56_G92_I0.6450.74
63_I70_I0.6430.73
54_L58_I0.6400.73
18_L21_L0.6390.73
12_G72_G0.6350.72
78_L89_L0.6340.72
16_G90_L0.6270.71
30_G52_D0.6250.71
32_D69_S0.6240.71
59_I62_G0.6190.70
24_L62_G0.6160.70
81_K94_G0.6160.70
20_G66_I0.6110.70
13_G90_L0.6100.69
2_R72_G0.6090.69
30_G56_G0.6080.69
43_Q46_P0.6080.69
4_A64_V0.6050.69
68_L75_G0.6050.69
20_G27_G0.6020.68
25_F28_G0.5970.68
1_K82_K0.5920.67
18_L31_S0.5900.67
4_A83_P0.5840.66
2_R93_A0.5750.65
8_L17_I0.5700.64
89_L96_L0.5670.64
32_D56_G0.5640.63
33_A51_L0.5600.63
12_G16_G0.5540.62
18_L30_G0.5490.61
14_I18_L0.5470.61
92_I95_I0.5460.61
9_G76_A0.5440.61
21_L31_S0.5390.60
40_E43_Q0.5320.59
33_A60_G0.5300.59
90_L97_S0.5260.58
62_G77_I0.5260.58
13_G78_L0.5230.58
22_F25_F0.5210.57
54_L61_L0.5210.57
19_G24_L0.5190.57
91_L95_I0.5180.57
3_T73_I0.5170.57
72_G77_I0.5160.57
75_G97_S0.5100.56
27_G55_G0.5030.55
68_L72_G0.5010.54
6_F83_P0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d31C 2 0.93 19.3 0.844 Contact Map
4p79A 1 0.78 18.8 0.845 Contact Map
3x29A 1 0.74 10.7 0.861 Contact Map
4pypA 1 0.97 8 0.869 Contact Map
2onkC 2 0.92 7.7 0.87 Contact Map
4i0uA 4 0.62 7.5 0.871 Contact Map
4ib4A 1 0.49 7.4 0.871 Contact Map
3ddlA 2 0.56 7 0.873 Contact Map
4tquN 1 1 7 0.873 Contact Map
4httA 1 0.97 6.5 0.875 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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