GREMLIN Database
2TM - 2TM domain
PFAM: PF13239 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 76 (74)
Sequences: 13569 (9499)
Seq/√Len: 1104.3
META: 0.899

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_H51_H3.1771.00
13_F52_A3.1381.00
28_I41_L2.8771.00
70_K73_E2.4361.00
50_F54_S2.1961.00
34_Y39_W2.0671.00
24_N41_L2.0531.00
31_N37_F1.8301.00
35_F38_L1.7341.00
23_V27_L1.6171.00
20_Y44_W1.5701.00
28_I35_F1.5351.00
28_I37_F1.5141.00
15_I19_V1.5021.00
66_W70_K1.4981.00
14_Y56_F1.4251.00
10_K74_L1.4061.00
67_E70_K1.3981.00
27_L40_P1.3861.00
20_Y45_G1.3471.00
7_V11_K1.2971.00
68_E72_E1.2861.00
9_K54_S1.2401.00
43_G47_G1.2261.00
46_I50_F1.2021.00
28_I32_L1.1881.00
20_Y24_N1.1811.00
6_R10_K1.1741.00
8_K12_G1.1661.00
51_H55_V1.1441.00
23_V44_W1.1431.00
16_H44_W1.1361.00
32_L35_F1.1231.00
31_N35_F1.1061.00
17_L48_L1.1011.00
53_L58_R1.0791.00
31_N38_L1.0701.00
24_N44_W1.0541.00
70_K74_L1.0371.00
66_W69_R1.0331.00
4_K8_K1.0041.00
34_Y38_L0.9961.00
26_F30_I0.9881.00
12_G54_S0.9731.00
10_K70_K0.9581.00
71_I74_L0.9471.00
52_A57_G0.9411.00
37_F41_L0.9151.00
16_H19_V0.9041.00
25_A29_V0.8981.00
67_E71_I0.8911.00
54_S58_R0.8611.00
12_G15_I0.8601.00
34_Y37_F0.8601.00
53_L57_G0.8461.00
68_E71_I0.8361.00
13_F55_V0.8301.00
44_W47_G0.8231.00
40_P43_G0.8051.00
12_G51_H0.7951.00
6_R9_K0.7931.00
52_A56_F0.7871.00
20_Y41_L0.7811.00
3_A7_V0.7391.00
22_V26_F0.7381.00
12_G16_H0.7371.00
31_N36_W0.7311.00
17_L21_V0.7301.00
15_I54_S0.7241.00
16_H48_L0.7011.00
49_A53_L0.7001.00
16_H20_Y0.6951.00
39_W43_G0.6931.00
65_D69_R0.6791.00
51_H54_S0.6791.00
13_F56_F0.6741.00
10_K52_A0.6721.00
38_L42_L0.6701.00
33_G36_W0.6661.00
28_I38_L0.6651.00
13_F17_L0.6641.00
44_W51_H0.6621.00
33_G37_F0.6541.00
21_V25_A0.6501.00
7_V71_I0.6471.00
44_W48_L0.6421.00
8_K11_K0.6401.00
59_N63_G0.6331.00
11_K15_I0.6121.00
12_G47_G0.6121.00
5_K9_K0.6051.00
49_A52_A0.6001.00
11_K67_E0.5981.00
31_N34_Y0.5981.00
37_F40_P0.5971.00
64_K67_E0.5961.00
28_I31_N0.5821.00
4_K71_I0.5801.00
36_W39_W0.5751.00
43_G46_I0.5721.00
47_G50_F0.5641.00
45_G48_L0.5541.00
36_W40_P0.5521.00
18_A22_V0.5451.00
11_K66_W0.5291.00
27_L30_I0.5261.00
17_L52_A0.5161.00
60_P63_G0.5061.00
4_K7_V0.5051.00
48_L51_H0.5031.00
60_P64_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ze3A 4 0.9868 8.9 0.865 Contact Map
4c5iC 1 0.1053 6.2 0.874 Contact Map
4c5eE 2 0.2368 5.4 0.878 Contact Map
3l1lA 2 0.8553 4.1 0.885 Contact Map
4bbjA 1 0.9868 3.8 0.887 Contact Map
1v54D 1 0.8816 3.5 0.888 Contact Map
2y69D 1 0.9211 3.3 0.89 Contact Map
2m8rA 1 0.4868 3.2 0.89 Contact Map
3mk7C 2 0.5526 3.1 0.892 Contact Map
3j08A 2 0.8553 2.9 0.894 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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