GREMLIN Database
CLU - Clustered mitochondria
PFAM: PF13236 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 221 (219)
Sequences: 663 (519)
Seq/√Len: 35.1
META: 0.477

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_D126_R7.9621.00
162_F198_G6.2681.00
69_I129_A6.1491.00
42_A127_L5.0711.00
104_L169_A4.8871.00
3_N7_Q3.8231.00
104_L214_L2.9781.00
177_P189_E2.8201.00
42_A46_I2.7721.00
96_H99_K2.7191.00
134_P201_G2.2520.99
63_K72_S2.2070.99
201_G205_R2.2020.99
42_A71_F2.1890.99
71_F129_A2.0800.99
14_R23_R2.0600.99
104_L192_G2.0510.99
197_K210_D2.0160.98
41_G71_F2.0160.98
193_S196_I1.9920.98
73_F127_L1.8940.97
74_A128_V1.8790.97
169_A214_L1.8710.97
6_F10_R1.8660.97
167_K177_P1.8530.97
158_A163_H1.8250.97
146_V162_F1.8200.97
46_I127_L1.8070.97
179_K189_E1.7930.96
201_G207_Y1.7550.96
65_I132_I1.7540.96
101_L114_T1.7500.96
9_A30_L1.7450.96
95_G121_D1.6930.95
13_P19_E1.6650.95
13_P16_T1.6560.94
56_K59_P1.6450.94
48_E57_E1.6440.94
149_S153_G1.6190.94
182_D185_G1.6160.94
3_N207_Y1.6120.94
72_S197_K1.6050.94
96_H212_A1.5900.93
203_D207_Y1.5470.92
179_K187_E1.5310.92
116_L131_S1.5050.91
198_G201_G1.4950.91
7_Q201_G1.4940.91
151_D155_T1.4890.91
95_G126_R1.4880.91
74_A94_A1.4750.90
198_G208_V1.4680.90
47_S123_R1.4530.90
159_D206_K1.4150.88
76_D87_D1.4090.88
38_A120_V1.4020.88
48_E56_K1.3320.85
15_E19_E1.3290.85
112_L165_L1.3140.84
134_P207_Y1.2920.83
38_A156_V1.2860.83
7_Q205_R1.2830.83
13_P23_R1.2780.82
120_V129_A1.2750.82
200_L214_L1.2610.82
4_E205_R1.2550.81
83_S86_G1.2540.81
76_D93_A1.2510.81
63_K197_K1.2510.81
104_L208_V1.2220.79
8_S11_E1.1900.78
156_V190_L1.1680.76
60_G199_H1.1490.75
101_L190_L1.1430.75
104_L121_D1.1330.74
6_F116_L1.1230.73
144_T199_H1.1200.73
100_G169_A1.1090.72
182_D188_V1.1040.72
195_D213_R1.0990.72
129_A172_A1.0920.71
167_K191_Y1.0840.71
200_L206_K1.0830.71
6_F42_A1.0810.70
12_L23_R1.0800.70
147_Y156_V1.0720.70
60_G197_K1.0680.69
34_F216_P1.0640.69
3_N11_E1.0570.69
64_Y139_G1.0540.68
119_L128_V1.0440.68
103_A215_F1.0310.67
36_E40_R1.0250.66
73_F125_F1.0080.65
3_N203_D1.0060.65
71_F127_L1.0030.65
151_D154_K1.0030.65
51_L56_K0.9990.64
5_E68_N0.9920.64
52_P56_K0.9760.62
149_S155_T0.9740.62
44_A48_E0.9670.62
175_L178_H0.9650.62
60_G72_S0.9620.61
68_N96_H0.9620.61
60_G63_K0.9610.61
139_G144_T0.9500.60
7_Q113_H0.9480.60
4_E16_T0.9260.58
161_E206_K0.9140.57
63_K116_L0.9140.57
90_A133_L0.9120.57
177_P191_Y0.9120.57
85_G90_A0.9040.56
3_N131_S0.9030.56
76_D79_G0.8990.56
2_W23_R0.8990.56
118_A161_E0.8900.55
1_D116_L0.8840.55
103_A173_L0.8790.54
147_Y190_L0.8790.54
70_F210_D0.8770.54
49_N73_F0.8760.54
16_T19_E0.8680.53
30_L35_V0.8620.53
173_L208_V0.8520.52
162_F208_V0.8510.52
103_A169_A0.8500.52
78_R110_P0.8450.51
54_N130_Q0.8410.51
60_G210_D0.8400.51
97_D197_K0.8340.50
70_F197_K0.8280.50
118_A123_R0.8280.50
47_S51_L0.8250.50
76_D90_A0.8200.49
74_A119_L0.8110.49
178_H194_V0.8100.48
167_K171_K0.8050.48
10_R29_K0.7990.47
163_H177_P0.7930.47
42_A54_N0.7860.46
34_F124_G0.7850.46
7_Q11_E0.7850.46
101_L105_N0.7840.46
48_E125_F0.7840.46
162_F200_L0.7830.46
101_L166_M0.7810.46
40_R160_E0.7780.46
72_S137_L0.7750.45
175_L192_G0.7730.45
118_A168_K0.7660.45
30_L68_N0.7630.44
51_L58_K0.7610.44
33_D41_G0.7610.44
10_R14_R0.7480.43
182_D186_K0.7470.43
145_L157_H0.7450.43
85_G93_A0.7400.42
166_M172_A0.7370.42
109_I112_L0.7370.42
61_G144_T0.7300.42
159_D200_L0.7240.41
119_L202_T0.7180.41
38_A186_K0.7160.40
21_L59_P0.7160.40
61_G72_S0.7160.40
98_L180_V0.7150.40
11_E113_H0.7150.40
40_R170_A0.7150.40
75_V215_F0.7130.40
12_L17_L0.7110.40
199_H210_D0.7100.40
72_S210_D0.7080.40
52_P59_P0.7070.40
127_L153_G0.7040.39
75_V188_V0.7020.39
77_S97_D0.7000.39
64_Y161_E0.6980.39
190_L211_L0.6980.39
150_V173_L0.6980.39
200_L208_V0.6940.39
156_V194_V0.6940.39
35_V118_A0.6900.38
140_E143_S0.6890.38
73_F176_K0.6890.38
72_S97_D0.6890.38
180_V188_V0.6880.38
192_G214_L0.6870.38
39_T42_A0.6850.38
71_F119_L0.6850.38
9_A12_L0.6830.38
112_L127_L0.6820.38
161_E165_L0.6820.38
19_E22_L0.6790.37
33_D71_F0.6770.37
7_Q207_Y0.6720.37
76_D118_A0.6700.37
101_L117_T0.6690.37
89_A130_Q0.6640.36
140_E144_T0.6640.36
198_G214_L0.6610.36
30_L181_L0.6610.36
90_A94_A0.6550.36
146_V200_L0.6550.36
5_E29_K0.6540.35
1_D4_E0.6540.35
100_G104_L0.6540.35
61_G197_K0.6530.35
63_K199_H0.6500.35
9_A65_I0.6490.35
97_D159_D0.6490.35
149_S193_S0.6490.35
89_A192_G0.6480.35
32_S47_S0.6470.35
45_I88_E0.6460.35
47_S177_P0.6430.35
144_T152_G0.6410.34
174_N196_I0.6410.34
60_G152_G0.6400.34
45_I127_L0.6390.34
120_V126_R0.6380.34
92_K217_P0.6350.34
52_P119_L0.6330.34
160_E164_E0.6290.34
67_N126_R0.6280.33
41_G44_A0.6270.33
1_D7_Q0.6250.33
92_K145_L0.6230.33
131_S149_S0.6230.33
117_T193_S0.6220.33
136_I151_D0.6200.33
4_E10_R0.6190.33
112_L123_R0.6190.33
154_K166_M0.6170.33
110_P168_K0.6170.33
8_S30_L0.6160.33
214_L219_A0.6130.32
65_I70_F0.6100.32
111_G122_Y0.6090.32
2_W10_R0.6080.32
118_A145_L0.6080.32
79_G82_K0.6070.32
33_D38_A0.6040.32
102_K169_A0.6040.32
2_W213_R0.6030.32
72_S199_H0.6020.31
72_S135_G0.6010.31
92_K101_L0.6000.31
104_L173_L0.6000.31
180_V208_V0.5980.31
109_I168_K0.5980.31
146_V159_D0.5960.31
39_T43_K0.5930.31
100_G103_A0.5930.31
33_D211_L0.5900.31
74_A122_Y0.5890.31
142_E146_V0.5890.31
127_L190_L0.5890.31
110_P160_E0.5870.30
101_L193_S0.5840.30
38_A88_E0.5830.30
74_A100_G0.5810.30
153_G213_R0.5810.30
15_E168_K0.5770.30
39_T64_Y0.5700.29
28_S31_A0.5690.29
162_F182_D0.5660.29
180_V204_G0.5650.29
181_L185_G0.5610.29
196_I211_L0.5610.29
29_K33_D0.5590.28
192_G196_I0.5570.28
39_T90_A0.5530.28
27_L30_L0.5530.28
44_A131_S0.5520.28
24_E79_G0.5510.28
63_K149_S0.5510.28
164_E167_K0.5500.28
17_L25_R0.5460.27
76_D147_Y0.5460.27
122_Y130_Q0.5440.27
19_E25_R0.5430.27
90_A93_A0.5420.27
64_Y154_K0.5410.27
46_I69_I0.5410.27
5_E21_L0.5390.27
51_L164_E0.5390.27
34_F129_A0.5360.27
150_V195_D0.5360.27
147_Y180_V0.5340.27
44_A67_N0.5320.27
13_P20_R0.5320.27
104_L175_L0.5320.27
74_A198_G0.5300.26
156_V180_V0.5300.26
18_Q27_L0.5270.26
72_S149_S0.5260.26
46_I125_F0.5240.26
104_L114_T0.5230.26
85_G89_A0.5230.26
102_K112_L0.5230.26
3_N201_G0.5200.26
129_A151_D0.5200.26
55_P97_D0.5160.25
92_K213_R0.5160.25
88_E160_E0.5150.25
60_G115_P0.5150.25
33_D65_I0.5140.25
48_E217_P0.5140.25
20_R24_E0.5140.25
147_Y175_L0.5130.25
147_Y198_G0.5130.25
38_A41_G0.5120.25
5_E25_R0.5110.25
88_E123_R0.5100.25
51_L54_N0.5080.25
91_R117_T0.5080.25
36_E47_S0.5070.25
215_F218_D0.5070.25
111_G130_Q0.5060.25
91_R196_I0.5040.25
178_H213_R0.5030.25
163_H204_G0.5020.25
30_L156_V0.5020.25
48_E59_P0.5010.25
212_A217_P0.5000.24
42_A73_F0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3epoA 2 0.086 9.6 0.96 Contact Map
2v8qA 1 0.3394 9.3 0.96 Contact Map
4g6tA 1 0.2896 8.2 0.961 Contact Map
2al6A 1 0.3891 7.6 0.962 Contact Map
2phcB 1 0.6063 7.4 0.962 Contact Map
2enjA 1 0.3077 7 0.962 Contact Map
1k3eA 2 0.2805 6.3 0.963 Contact Map
4ogqE 1 0.1403 6 0.964 Contact Map
4po6A 1 0.3665 5.7 0.964 Contact Map
4i7zE 1 0.1267 5.2 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0085 seconds.