GREMLIN Database
DUF4035 - Protein of unknown function (DUF4035)
PFAM: PF13227 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 51 (48)
Sequences: 758 (661)
Seq/√Len: 95.4
META: 0.85

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_A16_R4.0281.00
3_D8_F3.4521.00
17_A20_I2.5941.00
10_D13_A2.5471.00
26_G29_G2.5001.00
10_D16_R2.4971.00
19_Q39_P2.1541.00
18_A34_L2.0341.00
22_S34_L1.7081.00
18_A22_S1.6081.00
11_E15_L1.5881.00
25_A37_F1.3500.99
6_E10_D1.3300.99
20_I23_T1.3220.99
40_K43_K1.2220.98
32_F37_F1.1570.98
25_A32_F1.0920.97
44_E47_E1.0350.96
26_G30_K0.9710.94
3_D9_G0.9490.93
15_L19_Q0.9310.93
15_L41_F0.9280.92
17_A24_I0.8990.91
8_F41_F0.8870.91
17_A21_A0.8550.89
43_K47_E0.8440.88
45_E48_E0.8420.88
43_K46_E0.8390.88
19_Q23_T0.8230.87
2_Y10_D0.8200.87
33_K47_E0.7920.85
16_R39_P0.7840.84
18_A36_D0.7790.84
1_A5_L0.7770.84
2_Y41_F0.7660.83
30_K44_E0.7470.81
11_E38_M0.7360.80
26_G31_K0.7090.78
4_R28_K0.6840.75
17_A23_T0.6800.75
13_A17_A0.6650.73
25_A31_K0.6590.73
5_L36_D0.6580.72
44_E48_E0.6570.72
27_S30_K0.6540.72
43_K48_E0.6530.72
11_E40_K0.6390.70
25_A28_K0.6360.70
9_G30_K0.6330.70
15_L39_P0.6060.66
14_D39_P0.6060.66
35_S42_G0.6050.66
10_D41_F0.5960.65
31_K42_G0.5920.64
34_L39_P0.5880.64
5_L48_E0.5840.63
33_K38_M0.5840.63
20_I24_I0.5840.63
5_L42_G0.5780.63
15_L38_M0.5760.62
22_S32_F0.5710.62
16_R19_Q0.5610.60
19_Q25_A0.5590.60
3_D11_E0.5540.59
21_A37_F0.5510.59
11_E35_S0.5230.55
1_A48_E0.5190.54
4_R44_E0.5190.54
9_G26_G0.5180.54
9_G38_M0.5060.53
23_T32_F0.5060.53
6_E12_R0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wd8A 3 0.7451 11 0.851 Contact Map
3v3tA 1 0 4.1 0.878 Contact Map
1p9iA 2 0.5686 2.7 0.888 Contact Map
1zh8A 2 0.7451 2.5 0.89 Contact Map
4iovA 7 0 2.4 0.891 Contact Map
3dtpE 2 0.9804 2.2 0.894 Contact Map
4bzjA 2 0.8824 2 0.897 Contact Map
1nthA 5 0.4902 1.9 0.898 Contact Map
4ui9I 1 0.7451 1.8 0.898 Contact Map
1ej6D 1 0.5882 1.7 0.9 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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