GREMLIN Database
DUF4031 - Protein of unknown function (DUF4031)
PFAM: PF13223 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 79 (76)
Sequences: 5592 (3245)
Seq/√Len: 372.2
META: 0.894

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_H49_Y3.2071.00
23_L47_D2.4741.00
33_L59_A2.3441.00
27_H40_F2.2721.00
55_K58_R2.2651.00
68_T71_E2.2561.00
31_A37_R2.2461.00
40_F47_D2.0701.00
56_R66_E1.9741.00
19_V72_L1.9421.00
32_R62_A1.8411.00
60_V66_E1.7791.00
16_C56_R1.6631.00
33_L62_A1.6021.00
23_L40_F1.5491.00
56_R60_V1.5331.00
58_R62_A1.4871.00
36_P39_W1.4241.00
51_V59_A1.3821.00
58_R61_A1.3521.00
71_E74_R1.2941.00
18_L30_A1.2711.00
67_V72_L1.2631.00
69_S73_V1.1941.00
14_L53_A1.1651.00
13_R54_E1.1511.00
23_L27_H1.1451.00
57_A61_A1.1421.00
7_R53_A1.1351.00
72_L76_L1.1301.00
42_G46_R1.1211.00
19_V75_R1.0971.00
17_H50_D1.0811.00
19_V46_R1.0791.00
9_P14_L1.0771.00
67_V75_R1.0721.00
2_Y75_R1.0621.00
35_L39_W1.0521.00
27_H37_R1.0221.00
52_P55_K1.0171.00
19_V67_V1.0101.00
65_V75_R0.9931.00
10_A13_R0.9891.00
46_R76_L0.9821.00
42_G47_D0.9771.00
35_L38_R0.9701.00
73_V77_R0.9541.00
29_F64_A0.9351.00
21_D25_E0.9301.00
67_V71_E0.9191.00
41_Q50_D0.9171.00
35_L55_K0.9161.00
1_V20_S0.8761.00
27_H31_A0.8741.00
5_D8_W0.8451.00
16_C51_V0.8321.00
18_L29_F0.8321.00
29_F33_L0.8171.00
17_H48_H0.8091.00
40_F49_Y0.8081.00
10_A15_W0.8051.00
24_D28_A0.8041.00
9_P12_G0.8021.00
44_T47_D0.7961.00
2_Y20_S0.7831.00
35_L52_P0.7791.00
15_W52_P0.7641.00
39_W55_K0.7641.00
22_S25_E0.7641.00
70_R74_R0.7611.00
28_A32_R0.7291.00
69_S72_L0.7141.00
7_R14_L0.7111.00
5_D66_E0.7080.99
7_R16_C0.7060.99
1_V29_F0.7010.99
3_V59_A0.6990.99
42_G45_S0.6960.99
71_E75_R0.6950.99
7_R56_R0.6910.99
6_P53_A0.6680.99
15_W39_W0.6530.99
27_H30_A0.6430.99
72_L75_R0.6330.99
30_A40_F0.6300.99
6_P56_R0.6290.99
73_V76_L0.6250.99
2_Y67_V0.6230.99
2_Y19_V0.6220.99
20_S25_E0.6200.99
16_C66_E0.6110.99
13_R52_P0.6100.98
37_R49_Y0.6050.98
8_W12_G0.5990.98
10_A41_Q0.5990.98
69_S74_R0.5920.98
40_F44_T0.5820.98
8_W16_C0.5810.98
53_A57_A0.5770.98
12_G15_W0.5750.98
70_R73_V0.5740.98
3_V56_R0.5650.98
59_A64_A0.5590.97
53_A56_R0.5450.97
57_A66_E0.5410.97
69_S76_L0.5360.97
3_V6_P0.5360.97
5_D56_R0.5240.96
45_S76_L0.5190.96
4_D17_H0.5130.96
29_F63_G0.5110.96
19_V76_L0.5090.95
74_R77_R0.5030.95
16_C53_A0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kvnA 1 0.8987 35.1 0.872 Contact Map
1lngA 1 0.9114 34.9 0.872 Contact Map
3dluA 3 0.9241 26.3 0.88 Contact Map
3ktwA 1 0.8987 26 0.88 Contact Map
1jidA 1 0.9873 21.2 0.885 Contact Map
1zt2B 2 1 16.7 0.89 Contact Map
3ieyB 1 0.5823 9.5 0.901 Contact Map
3nvzC 2 1 9.3 0.902 Contact Map
1t3qB 2 1 8.9 0.903 Contact Map
1yf3A 1 0.9114 8.9 0.903 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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