GREMLIN Database
TerB_N - TerB N-terminal domain
PFAM: PF13208 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 219 (203)
Sequences: 1459 (1279)
Seq/√Len: 89.7
META: 0.788

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_Y95_F3.2361.00
127_L147_F3.2221.00
95_F99_Y3.0691.00
94_V120_F3.0301.00
101_L123_I2.8431.00
57_M90_S2.7141.00
61_P99_Y2.6581.00
11_R76_T2.6441.00
41_L44_A2.5621.00
95_F143_Y2.4641.00
131_L144_A2.4431.00
54_G90_S2.4271.00
59_Y99_Y2.3961.00
66_M96_L2.3901.00
187_A198_L2.3191.00
17_M20_V2.3091.00
73_A89_T2.2221.00
23_L28_Y2.1851.00
73_A93_Y2.1611.00
92_G95_F2.1501.00
104_R138_Y2.1191.00
56_F70_Q2.1091.00
95_F130_L2.0821.00
182_A202_W2.0781.00
113_G138_Y2.0621.00
121_W128_D2.0491.00
43_M75_L2.0361.00
112_D116_K1.9061.00
17_M21_G1.8871.00
44_A72_R1.8071.00
16_G19_Y1.7891.00
67_S70_Q1.7771.00
59_Y143_Y1.7711.00
11_R72_R1.6911.00
84_G88_D1.6241.00
128_D152_E1.6111.00
83_R129_R1.5801.00
176_P179_L1.5681.00
142_G146_S1.5671.00
60_W143_Y1.5441.00
72_R76_T1.5291.00
59_Y92_G1.5281.00
56_F66_M1.4871.00
60_W99_Y1.4851.00
104_R107_V1.4841.00
98_F117_L1.4761.00
57_M66_M1.4671.00
105_I120_F1.4570.99
60_W95_F1.4490.99
61_P92_G1.4380.99
13_I16_G1.4250.99
186_Y202_W1.3830.99
110_P116_K1.3480.99
56_F61_P1.3420.99
162_Y185_Q1.3220.99
139_S143_Y1.3130.99
82_R97_Y1.3090.99
23_L26_Y1.3080.99
104_R113_G1.3020.99
35_S64_S1.2940.99
140_F144_A1.2940.99
177_L181_L1.2650.98
14_P17_M1.2610.98
33_E103_R1.2540.98
9_A43_M1.2520.98
66_M70_Q1.2490.98
7_T10_G1.2460.98
51_D54_G1.2450.98
18_V37_I1.2370.98
91_I94_V1.2340.98
60_W139_S1.2270.98
24_S29_G1.2210.98
23_L27_G1.2040.98
131_L141_Y1.1990.98
105_I147_F1.1840.98
48_D72_R1.1840.98
131_L135_G1.1680.97
24_S27_G1.1670.97
15_G18_V1.1660.97
8_V13_I1.1590.97
6_V20_V1.1560.97
35_S39_P1.1470.97
129_R133_I1.1450.97
107_V113_G1.1400.97
92_G99_Y1.1360.97
90_S138_Y1.1330.97
55_P90_S1.1120.97
14_P18_V1.1080.97
59_Y139_S1.1000.96
212_E217_T1.1000.96
61_P143_Y1.0980.96
38_D41_L1.0840.96
50_Y72_R1.0720.96
25_S28_Y1.0700.96
48_D76_T1.0660.96
87_P94_V1.0630.96
24_S28_Y1.0540.95
91_I130_L1.0510.95
90_S93_Y1.0480.95
54_G73_A1.0460.95
16_G21_G1.0400.95
92_G130_L1.0370.95
176_P184_G1.0220.95
126_E129_R1.0160.94
59_Y130_L1.0100.94
47_E126_E1.0090.94
205_V210_D1.0080.94
173_Y176_P1.0060.94
98_F120_F0.9970.94
78_L100_G0.9920.94
146_S149_D0.9790.93
47_E83_R0.9770.93
113_G116_K0.9550.92
43_M46_F0.9410.92
115_E119_E0.9410.92
113_G121_W0.9400.92
87_P134_W0.9370.92
203_A207_A0.9280.91
13_I17_M0.9270.91
165_P170_A0.9230.91
179_L183_L0.9220.91
81_G97_Y0.9180.91
19_Y87_P0.9140.91
99_Y143_Y0.9100.90
97_Y116_K0.9030.90
44_A69_E0.9010.90
102_E144_A0.9000.90
52_Y73_A0.9000.90
202_W210_D0.8970.90
185_Q189_D0.8890.89
166_P202_W0.8750.89
166_P169_E0.8700.88
54_G70_Q0.8640.88
16_G20_V0.8640.88
120_F124_Y0.8550.87
105_I151_A0.8470.87
137_D141_Y0.8440.87
128_D132_P0.8400.86
11_R15_G0.8350.86
52_Y76_T0.8350.86
73_A90_S0.8340.86
37_I41_L0.8320.86
150_F154_L0.8230.85
184_G188_A0.8130.85
201_D209_L0.8110.84
186_Y199_P0.8070.84
14_P20_V0.8030.84
119_E123_I0.8020.84
91_I140_F0.8020.84
51_D73_A0.7990.84
197_P203_A0.7950.83
84_G186_Y0.7930.83
74_Y78_L0.7930.83
124_Y151_A0.7910.83
177_L188_A0.7900.83
99_Y131_L0.7890.83
8_V18_V0.7890.83
15_G19_Y0.7860.83
70_Q93_Y0.7810.82
43_M68_P0.7800.82
61_P96_L0.7760.82
113_G117_L0.7680.81
84_G149_D0.7630.81
98_F102_E0.7620.81
63_Y82_R0.7580.80
196_E199_P0.7570.80
92_G139_S0.7510.80
198_L213_Y0.7480.79
82_R183_L0.7470.79
118_A122_A0.7460.79
38_D126_E0.7400.79
61_P95_F0.7390.78
89_T93_Y0.7360.78
7_T12_T0.7340.78
57_M60_W0.7340.78
125_A155_R0.7330.78
212_E215_L0.7230.77
53_S189_D0.7190.77
76_T80_K0.7190.77
52_Y69_E0.7130.76
52_Y89_T0.7120.76
202_W205_V0.7110.76
107_V138_Y0.7090.76
20_V36_F0.7050.75
47_E119_E0.6950.74
92_G143_Y0.6940.74
84_G87_P0.6930.74
200_A204_L0.6890.73
203_A206_W0.6850.73
57_M143_Y0.6850.73
55_P152_E0.6820.73
12_T15_G0.6800.72
54_G72_R0.6750.72
99_Y102_E0.6750.72
19_Y98_F0.6750.72
55_P58_G0.6740.72
182_A186_Y0.6720.72
80_K87_P0.6700.71
97_Y120_F0.6690.71
147_F151_A0.6680.71
186_Y189_D0.6640.71
52_Y93_Y0.6620.70
78_L103_R0.6620.70
39_P71_R0.6600.70
6_V12_T0.6590.70
91_I95_F0.6580.70
54_G57_M0.6490.69
105_I124_Y0.6490.69
66_M143_Y0.6490.69
46_F71_R0.6490.69
61_P139_S0.6460.69
184_G187_A0.6420.68
80_K83_R0.6370.68
66_M138_Y0.6360.67
119_E122_A0.6360.67
73_A76_T0.6340.67
65_S178_S0.6320.67
35_S103_R0.6310.67
98_F127_L0.6280.66
14_P21_G0.6250.66
32_D65_S0.6240.66
207_A213_Y0.6240.66
204_L208_L0.6210.66
61_P140_F0.6210.66
207_A215_L0.6170.65
123_I130_L0.6130.65
25_S29_G0.6100.64
40_A63_Y0.6100.64
83_R133_I0.6090.64
34_P38_D0.6080.64
99_Y140_F0.6080.64
36_F40_A0.6050.64
57_M61_P0.6010.63
95_F126_E0.5990.63
57_M70_Q0.5990.63
11_R14_P0.5960.62
152_E155_R0.5940.62
21_G39_P0.5930.62
11_R17_M0.5920.62
18_V22_S0.5870.61
20_V35_S0.5860.61
87_P133_I0.5860.61
97_Y213_Y0.5820.61
165_P172_D0.5800.60
78_L102_E0.5790.60
57_M95_F0.5770.60
26_Y32_D0.5760.60
81_G102_E0.5750.60
17_M97_Y0.5740.60
12_T22_S0.5710.59
26_Y31_S0.5700.59
57_M92_G0.5700.59
74_Y101_L0.5690.59
104_R147_F0.5670.59
80_K84_G0.5650.58
145_S153_L0.5640.58
98_F130_L0.5620.58
214_R217_T0.5620.58
169_E175_L0.5610.58
78_L106_G0.5540.57
175_L184_G0.5530.57
205_V209_L0.5510.56
33_E36_F0.5510.56
81_G98_F0.5500.56
56_F92_G0.5500.56
32_D167_P0.5490.56
45_D79_A0.5470.56
94_V134_W0.5450.56
92_G137_D0.5450.56
127_L144_A0.5440.56
36_F39_P0.5430.55
117_L121_W0.5410.55
119_E126_E0.5400.55
123_I147_F0.5400.55
114_L135_G0.5360.54
46_F75_L0.5360.54
40_A105_I0.5340.54
36_F103_R0.5320.54
39_P42_F0.5310.54
95_F140_F0.5310.54
169_E173_Y0.5290.53
96_L206_W0.5260.53
52_Y70_Q0.5260.53
35_S202_W0.5260.53
167_P206_W0.5250.53
53_S83_R0.5230.53
148_L157_D0.5210.52
110_P114_L0.5210.52
11_R75_L0.5190.52
99_Y139_S0.5160.52
26_Y29_G0.5140.51
166_P205_V0.5140.51
123_I151_A0.5120.51
211_P215_L0.5110.51
88_D127_L0.5080.51
81_G100_G0.5070.50
19_Y22_S0.5050.50
106_G113_G0.5050.50
45_D141_Y0.5050.50
61_P91_I0.5020.50
91_I144_A0.5020.50
185_Q188_A0.5010.50
43_M72_R0.5010.50
57_M93_Y0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n75A 4 0.2603 6.5 0.954 Contact Map
1yvlA 3 0.5205 3 0.961 Contact Map
1sx5A 2 0.379 2.8 0.961 Contact Map
1yewA 3 0.2694 2.6 0.962 Contact Map
3kmhA 2 0.2557 2.5 0.962 Contact Map
3nttA 6 0 2.2 0.964 Contact Map
3vavA 4 0.3653 2.1 0.964 Contact Map
4pf1A 4 0.2557 2 0.965 Contact Map
1oy0A 4 0.3562 2 0.965 Contact Map
2p18A 1 0.5342 1.7 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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