GREMLIN Database
DUF4013 - Protein of unknown function (DUF4013)
PFAM: PF13197 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 167 (162)
Sequences: 6034 (5334)
Seq/√Len: 419.0
META: 0.923

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_V127_A4.2291.00
9_P12_G3.9081.00
22_R43_L3.6941.00
129_N132_E3.4301.00
49_K118_F2.8561.00
53_V118_F2.6921.00
25_R46_D2.2851.00
126_A129_N2.2801.00
117_R121_T2.1441.00
121_T126_A2.1431.00
39_D42_E2.1041.00
46_D49_K2.0431.00
21_L50_L2.0291.00
10_I13_W2.0291.00
28_I120_R2.0201.00
6_L9_P2.0181.00
42_E46_D1.9981.00
123_S126_A1.9691.00
34_L37_W1.9491.00
45_V48_L1.8811.00
26_N31_E1.8651.00
123_S129_N1.8451.00
22_R42_E1.8231.00
45_V49_K1.8061.00
161_I165_L1.7901.00
6_L12_G1.7841.00
14_F51_F1.7761.00
25_R122_G1.7381.00
52_V124_F1.7361.00
21_L118_F1.7041.00
22_R46_D1.6301.00
134_F138_R1.6241.00
117_R132_E1.6201.00
117_R129_N1.6061.00
22_R26_N1.5971.00
162_G165_L1.5951.00
117_R120_R1.5161.00
7_L12_G1.5091.00
57_Y114_A1.4711.00
140_N143_N1.4341.00
117_R136_L1.4191.00
28_I116_A1.3951.00
143_N146_I1.3851.00
9_P13_W1.3611.00
24_L116_A1.3491.00
117_R126_A1.3201.00
17_L51_F1.2891.00
62_L107_L1.2881.00
93_G96_L1.2851.00
94_L98_L1.2801.00
14_F44_F1.2771.00
21_L119_A1.2751.00
69_L72_A1.2661.00
49_K124_F1.2131.00
8_I12_G1.2061.00
72_A75_A1.1991.00
43_L46_D1.1941.00
71_V75_A1.1921.00
113_A136_L1.1871.00
158_A161_I1.1701.00
109_L112_P1.1581.00
118_F127_A1.1531.00
50_L115_L1.1511.00
53_V128_F1.1281.00
133_I137_I1.1261.00
75_A79_G1.1031.00
70_L73_L1.0851.00
160_L164_L1.0691.00
56_V128_F1.0671.00
4_L9_P1.0581.00
25_R29_A1.0451.00
116_A120_R1.0441.00
15_L43_L1.0371.00
149_L153_V1.0321.00
15_L40_W1.0291.00
135_R138_R1.0241.00
7_L13_W1.0231.00
57_Y133_I1.0101.00
56_V124_F1.0091.00
23_V35_P1.0081.00
4_L7_L1.0061.00
72_A76_L1.0001.00
113_A137_I0.9971.00
110_L134_F0.9701.00
93_G97_A0.9621.00
66_L69_L0.9551.00
158_A165_L0.9541.00
73_L77_A0.9491.00
37_W43_L0.9491.00
19_Y23_V0.9481.00
53_V124_F0.9341.00
5_L8_I0.9331.00
23_V27_V0.9321.00
98_L102_L0.9321.00
22_R39_D0.9151.00
114_A127_A0.9111.00
15_L44_F0.9041.00
22_R38_D0.9031.00
131_G135_R0.9021.00
46_D122_G0.8971.00
6_L10_I0.8751.00
108_A148_L0.8721.00
125_G131_G0.8651.00
54_G111_L0.8631.00
155_G159_G0.8561.00
69_L73_L0.8541.00
21_L25_R0.8501.00
156_F160_L0.8461.00
67_L71_V0.8371.00
137_I144_Y0.8291.00
100_G104_G0.8121.00
109_L137_I0.7991.00
58_A61_P0.7991.00
44_F47_G0.7961.00
144_Y148_L0.7951.00
77_A80_D0.7941.00
108_A112_P0.7891.00
18_G47_G0.7871.00
84_A88_L0.7871.00
73_L80_D0.7841.00
87_G91_L0.7821.00
56_V61_P0.7801.00
77_A81_S0.7791.00
117_R133_I0.7781.00
40_W43_L0.7771.00
68_I72_A0.7711.00
21_L46_D0.7701.00
49_K53_V0.7691.00
94_L97_A0.7661.00
27_V32_E0.7651.00
113_A144_Y0.7651.00
116_A119_A0.7601.00
12_G16_L0.7591.00
10_I14_F0.7521.00
114_A133_I0.7501.00
73_L76_L0.7461.00
79_G82_A0.7441.00
148_L151_L0.7431.00
124_F128_F0.7411.00
57_Y110_L0.7311.00
3_G7_L0.7301.00
156_F161_I0.7271.00
75_A78_G0.7251.00
69_L77_A0.7201.00
62_L100_G0.7191.00
100_G103_L0.7181.00
49_K52_V0.7101.00
17_L50_L0.6921.00
57_Y127_A0.6901.00
136_L144_Y0.6861.00
111_L114_A0.6861.00
76_L83_G0.6791.00
70_L76_L0.6781.00
133_I136_L0.6761.00
159_G163_I0.6711.00
147_A151_L0.6711.00
86_A90_A0.6691.00
12_G15_L0.6680.99
88_L91_L0.6650.99
90_A94_L0.6620.99
74_A77_A0.6570.99
130_F134_F0.6570.99
11_I15_L0.6560.99
97_A100_G0.6550.99
117_R128_F0.6540.99
161_I164_L0.6520.99
102_L105_L0.6510.99
103_L107_L0.6450.99
70_L74_A0.6450.99
53_V57_Y0.6450.99
91_L95_L0.6420.99
78_G83_G0.6420.99
122_G126_A0.6400.99
38_D43_L0.6390.99
65_A69_L0.6360.99
7_L10_I0.6320.99
120_R123_S0.6300.99
14_F48_L0.6260.99
42_E45_V0.6250.99
3_G12_G0.6230.99
53_V114_A0.6220.99
130_F133_I0.6220.99
158_A162_G0.6210.99
46_D118_F0.6170.99
103_L106_L0.6150.99
75_A81_S0.6130.99
142_G146_I0.6120.99
116_A136_L0.6120.99
65_A72_A0.6060.99
19_Y34_L0.6060.99
66_L72_A0.6050.99
100_G105_L0.6040.99
95_L99_L0.6020.99
132_E136_L0.6020.99
84_A89_G0.6000.99
71_V76_L0.5990.99
77_A83_G0.5990.99
58_A111_L0.5970.99
113_A116_A0.5960.99
159_G162_G0.5890.99
17_L54_G0.5890.99
26_N32_E0.5850.99
74_A81_S0.5850.99
49_K122_G0.5830.99
86_A89_G0.5830.99
16_L20_L0.5810.99
6_L13_W0.5810.99
41_G45_V0.5770.99
136_L139_A0.5770.99
74_A78_G0.5750.99
7_L14_F0.5740.98
5_L15_L0.5710.98
67_L76_L0.5710.98
118_F124_F0.5660.98
81_S84_A0.5660.98
80_D83_G0.5650.98
146_I149_L0.5630.98
76_L80_D0.5620.98
71_V74_A0.5530.98
65_A68_I0.5470.98
66_L70_L0.5470.98
145_L149_L0.5450.98
109_L144_Y0.5450.98
134_F137_I0.5410.98
160_L163_I0.5380.98
85_A88_L0.5350.98
51_F55_L0.5320.98
67_L70_L0.5320.98
121_T129_N0.5310.97
68_I75_A0.5280.97
107_L114_A0.5280.97
109_L148_L0.5270.97
58_A107_L0.5270.97
78_G82_A0.5260.97
15_L37_W0.5250.97
3_G13_W0.5250.97
68_I81_S0.5140.97
142_G152_L0.5110.97
60_L63_I0.5040.97
3_G6_L0.5040.97
109_L145_L0.5030.97
24_L119_A0.5010.96
61_P64_I0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tx3A 2 0.8084 14.1 0.89 Contact Map
3ayfA 2 0.1976 4.8 0.911 Contact Map
3ne5A 3 0.8623 4.3 0.913 Contact Map
3aqpA 1 0.6407 4.1 0.914 Contact Map
4k0jA 3 0.7904 3.3 0.918 Contact Map
4ldeA 1 0.6527 2.8 0.921 Contact Map
3rqwA 4 0.3054 2.6 0.922 Contact Map
4n6hA 1 0.7305 2.6 0.922 Contact Map
4yayA 1 0.6527 2.1 0.926 Contact Map
3mktA 1 0.8982 2 0.927 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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