GREMLIN Database
DUF4011 - Protein of unknown function (DUF4011)
PFAM: PF13195 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 166 (160)
Sequences: 5930 (4713)
Seq/√Len: 372.6
META: 0.867

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_Y126_P3.9301.00
116_E128_R3.3541.00
116_E126_P3.1261.00
137_E150_R2.7531.00
99_A107_T2.7461.00
139_E150_R2.7341.00
97_R101_E2.5261.00
7_L127_R2.4331.00
111_A114_F2.2641.00
33_F37_V2.1961.00
91_K95_K2.1891.00
28_D31_E2.1091.00
34_D39_G2.0311.00
120_S123_S2.0151.00
42_S150_R2.0071.00
134_V156_I1.9321.00
117_W129_A1.9221.00
7_L13_N1.8431.00
158_V163_L1.8361.00
20_S95_K1.8241.00
90_R94_R1.7861.00
27_P73_D1.7721.00
14_F114_F1.7441.00
35_L43_L1.7401.00
31_E34_D1.7301.00
45_F89_L1.6621.00
118_Y123_S1.6351.00
99_A103_Q1.6291.00
100_L106_N1.6151.00
32_L76_L1.6061.00
119_E123_S1.5971.00
81_T84_E1.5651.00
46_L75_R1.5591.00
90_R93_Y1.5501.00
96_A108_L1.5391.00
5_L12_L1.5231.00
14_F21_T1.5201.00
139_E148_R1.5111.00
13_N127_R1.5081.00
111_A133_L1.4881.00
3_L161_T1.4841.00
82_P86_E1.4831.00
12_L129_A1.4401.00
35_L74_N1.4211.00
37_V134_V1.4201.00
44_R75_R1.4101.00
4_D8_R1.3931.00
112_L134_V1.3651.00
115_L162_L1.3641.00
136_V149_L1.3641.00
84_E88_R1.3571.00
30_D34_D1.3541.00
21_T92_L1.3381.00
4_D9_N1.2721.00
141_K148_R1.2701.00
42_S148_R1.2391.00
118_Y124_E1.2331.00
51_R54_E1.2231.00
93_Y97_R1.2131.00
71_L77_Q1.1861.00
55_E60_L1.1791.00
80_L88_R1.1681.00
34_D38_D1.1591.00
43_L76_L1.1591.00
71_L74_N1.1551.00
33_F112_L1.1551.00
22_L89_L1.1501.00
23_R79_L1.1331.00
45_F78_T1.1321.00
74_N77_Q1.1161.00
95_K98_T1.1111.00
118_Y127_R1.1101.00
90_R140_R1.0961.00
119_E165_K1.0941.00
115_L131_L1.0871.00
68_A71_L1.0791.00
90_R147_F1.0751.00
84_E87_K1.0661.00
70_R75_R1.0511.00
151_L156_I1.0401.00
47_P82_P1.0291.00
137_E152_R1.0281.00
28_D71_L1.0101.00
44_R74_N1.0021.00
7_L129_A0.9991.00
42_S139_E0.9961.00
19_K91_K0.9851.00
11_L133_L0.9791.00
44_R148_R0.9771.00
110_L149_L0.9691.00
71_L75_R0.9461.00
131_L158_V0.9381.00
129_A165_K0.9311.00
157_E160_P0.9261.00
100_L137_E0.9241.00
16_P23_R0.9211.00
6_S10_R0.9181.00
142_S146_G0.9101.00
67_A71_L0.9101.00
98_T102_E0.8871.00
98_T101_E0.8871.00
134_V151_L0.8841.00
10_R15_R0.8701.00
161_T164_E0.8601.00
45_F85_L0.8541.00
6_S12_L0.8501.00
35_L41_K0.8491.00
24_I45_F0.8441.00
118_Y121_D0.8411.00
18_K21_T0.8371.00
78_T85_L0.8341.00
70_R77_Q0.8331.00
5_L9_N0.8311.00
93_Y140_R0.8281.00
91_K94_R0.8251.00
30_D33_F0.8221.00
119_E127_R0.8201.00
10_R21_T0.8201.00
7_L10_R0.8171.00
40_E74_N0.8101.00
26_D71_L0.8001.00
29_P112_L0.7921.00
117_W165_K0.7891.00
160_P164_E0.7861.00
15_R21_T0.7731.00
14_F17_T0.7721.00
143_A146_G0.7671.00
31_E35_L0.7631.00
44_R146_G0.7591.00
103_Q107_T0.7561.00
67_A70_R0.7521.00
63_D66_L0.7511.00
25_V79_L0.7441.00
31_E72_K0.7421.00
65_E68_A0.7411.00
142_S145_S0.7351.00
115_L166_L0.7271.00
93_Y147_F0.7261.00
43_L46_L0.7251.00
15_R18_K0.7221.00
110_L136_V0.7211.00
94_R98_T0.7141.00
27_P31_E0.7121.00
10_R13_N0.7111.00
3_L164_E0.7111.00
33_F38_D0.7090.99
141_K144_R0.7070.99
28_D73_D0.7050.99
7_L125_E0.7050.99
26_D77_Q0.7040.99
19_K84_E0.6940.99
65_E69_E0.6940.99
138_L149_L0.6930.99
96_A106_N0.6890.99
99_A105_V0.6860.99
32_L36_L0.6840.99
140_R147_F0.6800.99
61_E64_E0.6790.99
46_L77_Q0.6790.99
162_L166_L0.6770.99
89_L138_L0.6760.99
108_L136_V0.6710.99
38_D41_K0.6690.99
12_L161_T0.6560.99
83_E87_K0.6540.99
113_G117_W0.6520.99
24_I27_P0.6520.99
106_N154_E0.6510.99
106_N152_R0.6430.99
132_L156_I0.6330.99
100_L103_Q0.6310.99
10_R95_K0.6290.99
88_R95_K0.6250.99
152_R155_E0.6230.99
33_F156_I0.6210.99
3_L13_N0.6200.99
23_R78_T0.6190.99
10_R20_S0.6160.99
80_L85_L0.6120.99
68_A72_K0.6120.99
69_E73_D0.6120.99
7_L15_R0.6110.99
63_D73_D0.6070.98
15_R24_I0.6040.98
89_L147_F0.6020.98
95_K99_A0.5990.98
70_R73_D0.5980.98
62_P67_A0.5900.98
73_D77_Q0.5900.98
10_R17_T0.5900.98
54_E61_E0.5880.98
14_F18_K0.5850.98
17_T20_S0.5840.98
54_E60_L0.5840.98
115_L125_E0.5830.98
26_D32_L0.5810.98
64_E68_A0.5700.98
82_P87_K0.5670.98
88_R91_K0.5670.98
143_A148_R0.5630.97
62_P65_E0.5610.97
17_T21_T0.5600.97
156_I160_P0.5580.97
19_K88_R0.5570.97
16_P114_F0.5550.97
121_D124_E0.5550.97
94_R97_R0.5540.97
149_L152_R0.5520.97
7_L14_F0.5480.97
66_L77_Q0.5480.97
102_E106_N0.5430.97
159_N162_L0.5420.97
95_K107_T0.5400.97
22_L88_R0.5400.97
108_L138_L0.5390.97
21_T25_V0.5380.97
62_P66_L0.5350.97
27_P71_L0.5320.96
12_L162_L0.5280.96
43_L71_L0.5280.96
32_L43_L0.5270.96
147_F150_R0.5270.96
12_L85_L0.5250.96
20_S91_K0.5250.96
12_L127_R0.5230.96
80_L84_E0.5220.96
117_W133_L0.5220.96
112_L132_L0.5190.96
41_K74_N0.5170.96
63_D72_K0.5160.96
60_L66_L0.5130.96
11_L104_G0.5120.96
7_L119_E0.5090.95
24_I78_T0.5080.95
16_P21_T0.5080.95
50_E60_L0.5080.95
5_L109_Y0.5020.95
66_L69_E0.5010.95
25_V29_P0.5000.95
85_L96_A0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1x9yA 1 0.5542 3.1 0.938 Contact Map
2l0cA 1 0.2349 1.4 0.949 Contact Map
3rd4A 3 0.2108 1.4 0.949 Contact Map
3tweA 2 0.1566 1.4 0.949 Contact Map
1qc6A 2 0.3675 1.4 0.949 Contact Map
2c1lA 2 0.5301 1.3 0.95 Contact Map
1lngA 1 0.2048 1.3 0.95 Contact Map
4lnsA 2 0.3976 1.2 0.951 Contact Map
4f0hA 4 0.9217 1.2 0.951 Contact Map
1n0wB 1 0.1988 1.1 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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