GREMLIN Database
DUF4010 - Domain of unknown function (DUF4010)
PFAM: PF13194 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 210 (209)
Sequences: 9494 (7252)
Seq/√Len: 501.7
META: 0.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_K130_K3.5741.00
102_A106_R3.2931.00
173_L190_A3.1301.00
144_A148_Y2.9681.00
76_A83_L2.8941.00
71_V195_A2.8921.00
30_G38_T2.8841.00
143_A146_Q2.6871.00
75_V86_L2.6001.00
143_A147_E2.5211.00
159_A193_I2.3901.00
89_P92_A2.3291.00
158_A190_A2.1441.00
155_Y193_I2.1431.00
204_G208_V2.0681.00
72_L83_L1.9871.00
79_N177_A1.9601.00
65_A97_A1.9551.00
80_P84_R1.9521.00
159_A197_S1.9441.00
42_L59_G1.8811.00
177_A187_A1.8651.00
154_L190_A1.8231.00
99_A103_L1.7901.00
142_S160_L1.7551.00
46_S56_L1.7491.00
12_V16_L1.7101.00
103_L107_R1.6691.00
129_L133_L1.6631.00
75_V174_A1.6531.00
145_A157_L1.6321.00
81_A84_R1.6261.00
53_A57_A1.6191.00
45_R48_E1.6091.00
36_T201_V1.5931.00
175_R178_A1.5731.00
155_Y189_L1.5551.00
76_A80_P1.5451.00
71_V170_T1.5361.00
42_L56_L1.5271.00
169_I194_A1.5251.00
154_L173_L1.5081.00
27_G31_G1.4791.00
201_V205_L1.4731.00
39_T206_A1.4721.00
87_A91_L1.4671.00
205_L209_L1.4561.00
144_A147_E1.4511.00
85_A188_A1.4121.00
84_R87_A1.4041.00
67_M199_T1.3891.00
46_S53_A1.3801.00
43_A60_I1.3371.00
158_A173_L1.3321.00
145_A148_Y1.3251.00
45_R49_E1.3241.00
69_L94_A1.3231.00
170_T174_A1.3211.00
28_L66_V1.2891.00
49_E52_L1.2811.00
68_F195_A1.2711.00
201_V204_G1.2641.00
24_L58_A1.2541.00
75_V82_L1.2461.00
17_L25_L1.2341.00
154_L182_L1.2281.00
56_L59_G1.2271.00
123_F127_P1.2251.00
184_A188_A1.2071.00
124_E127_P1.1971.00
40_L209_L1.1911.00
98_L102_A1.1841.00
88_L92_A1.1831.00
167_D202_K1.1811.00
163_L201_V1.1731.00
11_Y121_N1.1651.00
133_L137_V1.1531.00
68_F93_M1.1521.00
174_A187_A1.1471.00
155_Y186_V1.1471.00
94_A101_A1.1321.00
67_M195_A1.1241.00
72_L90_L1.1211.00
44_R48_E1.1211.00
186_V189_L1.1111.00
23_L55_A1.1101.00
106_R109_R1.1091.00
54_R107_R1.1051.00
125_L129_L1.1011.00
142_S146_Q1.1001.00
173_L187_A1.0861.00
69_L72_L1.0831.00
131_F135_F1.0811.00
177_A184_A1.0781.00
166_V195_A1.0771.00
161_S169_I1.0771.00
100_A104_L1.0681.00
185_A189_L1.0681.00
74_L77_V1.0671.00
186_V190_A1.0601.00
165_D198_N1.0551.00
33_V119_L1.0461.00
103_L106_R1.0421.00
81_A85_A1.0321.00
90_L94_A1.0281.00
70_R167_D1.0251.00
7_S11_Y1.0181.00
183_S186_V1.0141.00
38_T42_L1.0101.00
52_L56_L1.0051.00
138_V157_L1.0051.00
39_T60_I1.0001.00
140_L144_A0.9991.00
106_R110_R0.9951.00
146_Q151_D0.9931.00
181_G185_A0.9911.00
23_L56_L0.9901.00
78_L171_L0.9861.00
86_L191_I0.9851.00
50_P53_A0.9821.00
44_R47_R0.9821.00
24_L27_G0.9811.00
27_G55_A0.9801.00
13_A29_L0.9761.00
79_N178_A0.9731.00
82_L174_A0.9701.00
62_L101_A0.9641.00
67_M70_R0.9621.00
31_G38_T0.9621.00
145_A149_F0.9611.00
159_A200_L0.9611.00
40_L205_L0.9601.00
91_L95_L0.9571.00
152_A156_A0.9501.00
66_V167_D0.9331.00
72_L76_A0.9301.00
153_G156_A0.9261.00
91_L94_A0.9251.00
59_G123_F0.9221.00
205_L208_V0.9201.00
153_G157_L0.9171.00
35_S67_M0.9151.00
96_V100_A0.9051.00
158_A169_I0.8981.00
196_L200_L0.8951.00
94_A97_A0.8921.00
18_G22_G0.8901.00
163_L197_S0.8811.00
74_L78_L0.8811.00
24_L62_L0.8771.00
134_L138_V0.8761.00
105_Y109_R0.8721.00
89_P93_M0.8681.00
11_Y122_P0.8611.00
142_S157_L0.8581.00
94_A98_L0.8571.00
102_A105_Y0.8561.00
5_G9_A0.8521.00
192_L195_A0.8511.00
95_L99_A0.8511.00
157_L161_S0.8451.00
10_G29_L0.8401.00
58_A105_Y0.8401.00
162_G197_S0.8381.00
182_L187_A0.8291.00
13_A16_L0.8291.00
98_L101_A0.8271.00
4_S8_F0.8221.00
71_V166_V0.8221.00
90_L93_M0.8191.00
22_G26_T0.8161.00
145_A153_G0.8131.00
141_A157_L0.8121.00
39_T64_S0.8111.00
145_A160_L0.8101.00
2_L78_L0.8091.00
65_A98_L0.7971.00
83_L87_A0.7871.00
28_L62_L0.7851.00
78_L174_A0.7851.00
75_V170_T0.7831.00
66_V70_R0.7801.00
74_L174_A0.7731.00
61_L97_A0.7701.00
203_A207_L0.7701.00
161_S164_T0.7691.00
137_V141_A0.7691.00
196_L199_T0.7621.00
7_S127_P0.7611.00
130_K134_L0.7531.00
158_A162_G0.7431.00
2_L77_V0.7421.00
3_I131_F0.7421.00
90_L192_L0.7411.00
149_F156_A0.7401.00
3_I128_A0.7391.00
94_A105_Y0.7391.00
14_V29_L0.7371.00
13_A17_L0.7361.00
70_R122_P0.7321.00
82_L191_I0.7281.00
70_R73_V0.7241.00
92_A95_L0.7241.00
55_A59_G0.7241.00
105_Y108_A0.7241.00
65_A101_A0.7171.00
4_S128_A0.7161.00
138_V161_S0.7151.00
60_I206_A0.7101.00
172_S175_R0.7101.00
182_L186_V0.7101.00
8_F123_F0.7081.00
18_G21_R0.7081.00
75_V83_L0.6971.00
104_L108_A0.6921.00
84_R88_L0.6911.00
67_M166_V0.6891.00
66_V98_L0.6871.00
189_L193_I0.6861.00
38_T41_S0.6791.00
142_S176_L0.6761.00
173_L191_I0.6751.00
100_A103_L0.6721.00
110_R113_A0.6721.00
42_L60_I0.6641.00
64_S97_A0.6621.00
99_A102_A0.6591.00
8_F121_N0.6591.00
71_V167_D0.6571.00
2_L10_G0.6571.00
150_G153_G0.6571.00
61_L64_S0.6571.00
27_G58_A0.6441.00
199_T203_A0.6371.00
35_S63_A0.6341.00
4_S132_A0.6341.00
79_N174_A0.6331.00
2_L6_I0.6321.00
93_M192_L0.6301.00
167_D198_N0.6301.00
4_S135_F0.6301.00
85_A184_A0.6201.00
57_A61_L0.6191.00
41_S45_R0.6181.00
136_A140_L0.6151.00
37_A41_S0.6131.00
93_M97_A0.6121.00
86_L188_A0.6070.99
73_V77_V0.6010.99
56_L60_I0.6000.99
54_R110_R0.5990.99
11_Y15_R0.5980.99
142_S145_A0.5940.99
203_A206_A0.5910.99
52_L55_A0.5870.99
41_S44_R0.5860.99
72_L86_L0.5850.99
64_S67_M0.5850.99
85_A185_A0.5840.99
204_G207_L0.5830.99
73_V76_A0.5820.99
135_F171_L0.5820.99
197_S200_L0.5810.99
171_L175_R0.5790.99
39_T43_A0.5750.99
206_A210_G0.5720.99
55_A58_A0.5710.99
141_A145_A0.5690.99
200_L204_G0.5680.99
58_A62_L0.5640.99
119_L122_P0.5620.99
161_S168_A0.5620.99
133_L136_A0.5610.99
130_K133_L0.5610.99
29_L145_A0.5610.99
85_A88_L0.5600.99
71_V165_D0.5550.99
155_Y190_A0.5530.99
17_L21_R0.5480.99
166_V194_A0.5470.99
176_L182_L0.5410.99
14_V17_L0.5400.99
135_F142_S0.5390.99
19_A52_L0.5380.99
88_L91_L0.5370.99
183_S189_L0.5370.99
109_R115_A0.5340.99
82_L85_A0.5330.99
164_T201_V0.5320.99
192_L196_L0.5320.99
92_A96_V0.5300.99
176_L180_G0.5300.99
36_T167_D0.5240.98
90_L97_A0.5230.98
134_L137_V0.5230.98
185_A188_A0.5210.98
32_L70_R0.5200.98
91_L98_L0.5200.98
57_A60_I0.5190.98
74_L142_S0.5170.98
81_A184_A0.5120.98
96_V103_L0.5110.98
143_A148_Y0.5080.98
11_Y144_A0.5080.98
40_L44_R0.5080.98
11_Y119_L0.5070.98
32_L73_V0.5060.98
151_D186_V0.5050.98
58_A101_A0.5030.98
38_T63_A0.5030.98
169_I173_L0.5020.98
149_F160_L0.5010.98
135_F164_T0.5000.98
1_V4_S0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zuxA 1 0.4952 27.5 0.932 Contact Map
4f35D 2 0.8952 26 0.933 Contact Map
2cfqA 1 0.5667 20.4 0.936 Contact Map
1pw4A 1 0.5714 12.4 0.942 Contact Map
4n7wA 2 0.5095 9.8 0.944 Contact Map
4ikvA 1 0.5095 8.8 0.946 Contact Map
2xq2A 2 0.4762 6.9 0.948 Contact Map
4cofA 3 0.481 6.6 0.949 Contact Map
4b19A 1 0.1429 4.9 0.951 Contact Map
4xnjA 1 0.481 4.7 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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