GREMLIN Database
PDGLE - PDGLE domain
PFAM: PF13190 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 89 (81)
Sequences: 8377 (6080)
Seq/√Len: 675.6
META: 0.911

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_W27_D5.1971.00
22_E56_D2.5511.00
8_G12_P2.0401.00
41_H44_A2.0231.00
59_F68_G1.9741.00
40_F44_A1.9331.00
9_V12_P1.9281.00
40_F43_A1.8071.00
77_V81_F1.7711.00
41_H45_A1.7431.00
80_V84_A1.6541.00
38_G41_H1.6311.00
7_A70_I1.6071.00
42_A45_A1.5691.00
47_L50_K1.5351.00
84_A88_G1.5181.00
6_L10_L1.5131.00
22_E69_T1.5121.00
46_A49_E1.4751.00
8_G70_I1.4591.00
42_A46_A1.4111.00
43_A48_Q1.4011.00
25_A29_T1.3471.00
39_G42_A1.3311.00
5_L9_V1.3081.00
58_A68_G1.2961.00
54_L72_A1.2941.00
39_G43_A1.2691.00
44_A50_K1.2301.00
43_A46_A1.2301.00
54_L59_F1.2261.00
59_F62_I1.2161.00
12_P69_T1.2011.00
82_G85_L1.1751.00
7_A11_S1.1111.00
59_F71_L1.1111.00
78_L82_G1.1071.00
46_A50_K1.0761.00
69_T72_A1.0711.00
23_W26_E1.0651.00
62_I65_E1.0581.00
44_A48_Q1.0461.00
8_G74_V1.0251.00
77_V80_V1.0221.00
63_G66_A1.0051.00
54_L68_G0.9921.00
52_A55_P0.9911.00
39_G44_A0.9871.00
8_G11_S0.9791.00
12_P70_I0.9551.00
59_F75_V0.9541.00
4_L74_V0.9521.00
81_F85_L0.9471.00
6_L9_V0.9471.00
11_S70_I0.9241.00
41_H47_L0.9141.00
69_T73_G0.9111.00
45_A49_E0.9071.00
81_F84_A0.9051.00
38_G42_A0.9001.00
44_A47_L0.8901.00
40_F48_Q0.8801.00
9_V13_F0.8551.00
25_A28_L0.8381.00
82_G86_G0.8361.00
15_S19_D0.8331.00
43_A47_L0.8131.00
20_G24_V0.8111.00
45_A48_Q0.8021.00
25_A31_T0.7791.00
41_H48_Q0.7631.00
10_L24_V0.7591.00
54_L58_A0.7511.00
41_H46_A0.7411.00
13_F66_A0.7401.00
11_S69_T0.7181.00
54_L75_V0.7141.00
62_I68_G0.6921.00
53_P79_L0.6711.00
4_L8_G0.6651.00
7_A77_V0.6611.00
59_F63_G0.6541.00
40_F46_A0.6491.00
40_F47_L0.6481.00
43_A50_K0.6471.00
81_F88_G0.6401.00
24_V27_D0.6361.00
24_V28_L0.6311.00
44_A49_E0.6271.00
3_A7_A0.6241.00
26_E56_D0.6241.00
2_A6_L0.6221.00
62_I71_L0.6201.00
58_A69_T0.6111.00
67_L71_L0.5891.00
21_L24_V0.5881.00
6_L16_S0.5881.00
11_S73_G0.5851.00
26_E31_T0.5841.00
3_A77_V0.5831.00
38_G43_A0.5811.00
61_G86_G0.5781.00
73_G77_V0.5741.00
77_V84_A0.5671.00
51_T55_P0.5641.00
16_S23_W0.5551.00
8_G73_G0.5451.00
16_S22_E0.5431.00
80_V85_L0.5381.00
31_T38_G0.5351.00
78_L81_F0.5351.00
26_E30_G0.5311.00
40_F45_A0.5271.00
12_P81_F0.5271.00
70_I74_V0.5251.00
67_L70_I0.5200.99
43_A49_E0.5170.99
70_I73_G0.5150.99
3_A81_F0.5140.99
58_A62_I0.5070.99
5_L8_G0.5000.99
48_Q51_T0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iijA 1 0.3258 16.3 0.874 Contact Map
2m20A 2 0.2697 15.8 0.874 Contact Map
2l2tA 2 0.3483 12.7 0.88 Contact Map
2kluA 1 0.3146 10 0.885 Contact Map
2jwaA 2 0.3596 9.7 0.886 Contact Map
2kncB 1 0.3596 8.6 0.889 Contact Map
2l9uA 2 0.2921 6.8 0.894 Contact Map
2ks1B 1 0.3596 6.7 0.894 Contact Map
2z6oA 1 0.3708 3.7 0.907 Contact Map
1fftA 1 0.382 3.2 0.909 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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