GREMLIN Database
DUF4007 - Protein of unknown function (DUF4007)
PFAM: PF13182 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 290 (285)
Sequences: 2522 (2091)
Seq/√Len: 123.9
META: 0.847

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_V50_I5.0941.00
15_K19_D4.5231.00
74_L100_L4.1211.00
92_A205_P3.6761.00
17_G54_L3.6741.00
206_P254_E3.5331.00
77_L84_W3.3811.00
59_L75_G3.3531.00
133_K147_E3.2641.00
61_E70_E3.1321.00
229_E233_G3.0341.00
21_V60_I2.9901.00
78_L93_T2.8731.00
5_E48_K2.8311.00
128_L154_V2.7761.00
212_A241_F2.7671.00
97_L179_L2.7401.00
88_L93_T2.6921.00
129_L154_V2.6821.00
124_T127_E2.5721.00
57_F97_L2.5191.00
114_F157_F2.4981.00
213_L230_L2.4771.00
206_P251_R2.4671.00
244_D247_S2.4271.00
196_F242_K2.4221.00
114_F128_L2.4151.00
215_D282_P2.4001.00
77_L287_E2.2971.00
22_K76_K2.2531.00
114_F196_F2.2461.00
92_A208_I2.1611.00
231_A248_L2.1581.00
117_E234_P2.0971.00
5_E49_S2.0181.00
110_T157_F2.0081.00
209_F248_L2.0041.00
58_G100_L2.0021.00
99_W215_D2.0011.00
74_L78_L1.9981.00
18_Y76_K1.9791.00
37_I47_V1.8191.00
148_N152_R1.7781.00
217_W275_F1.7711.00
54_L60_I1.7501.00
17_G50_I1.7401.00
125_R151_K1.7271.00
90_D289_Y1.7021.00
103_S215_D1.6961.00
18_Y71_L1.6951.00
92_A289_Y1.6731.00
76_K80_G1.6631.00
113_W131_A1.6571.00
209_F251_R1.6421.00
18_Y80_G1.6231.00
58_G104_N1.5951.00
186_R197_N1.5891.00
52_Y108_A1.5811.00
96_L208_I1.5751.00
56_A101_L1.5631.00
20_A30_V1.5551.00
117_E135_Y1.5491.00
100_L103_S1.5421.00
213_L273_L1.5291.00
102_A240_V1.4901.00
60_I69_L1.4851.00
73_E76_K1.4731.00
132_L150_L1.4611.00
263_R276_K1.4591.00
57_F101_L1.4391.00
44_K48_K1.4331.00
100_L211_Y1.4261.00
152_R155_D1.3951.00
103_S240_V1.3831.00
113_W132_L1.3581.00
63_D70_E1.3451.00
116_N240_V1.3451.00
204_L243_L1.3321.00
12_G178_P1.3271.00
133_K150_L1.3241.00
281_D284_E1.3031.00
35_D39_R1.2881.00
148_N151_K1.2871.00
256_E260_G1.2761.00
125_R155_D1.2621.00
147_E151_K1.2451.00
265_S274_Q1.2320.99
230_L248_L1.2130.99
129_L150_L1.2010.99
14_L57_F1.1910.99
88_L94_L1.1870.99
220_R229_E1.1870.99
284_E287_E1.1840.99
24_D33_D1.1760.99
115_F157_F1.1700.99
210_L285_I1.1410.99
9_L177_S1.1410.99
59_L74_L1.1360.99
9_L57_F1.1290.99
230_L237_P1.1270.99
110_T132_L1.1230.99
24_D29_N1.1140.99
73_E283_L1.1130.99
209_F213_L1.1110.99
112_Y235_G1.0940.99
211_Y215_D1.0870.99
136_A145_V1.0840.99
210_L255_L1.0830.99
95_W248_L1.0690.98
2_S149_T1.0650.98
5_E45_N1.0490.98
33_D39_R1.0480.98
118_F131_A1.0480.98
123_F194_Y1.0440.98
94_L160_T1.0370.98
11_Y178_P1.0310.98
157_F160_T1.0280.98
8_P159_R1.0240.98
112_Y116_N1.0180.98
71_L76_K1.0150.98
207_E289_Y1.0140.98
256_E263_R1.0080.98
55_L69_L1.0080.98
283_L287_E1.0070.98
55_L107_R1.0050.98
102_A112_Y0.9980.98
109_T132_L0.9900.97
23_E39_R0.9780.97
36_A47_V0.9750.97
149_T153_D0.9740.97
129_L147_E0.9720.97
252_L256_E0.9700.97
6_T155_D0.9670.97
58_G74_L0.9630.97
118_F123_F0.9620.97
100_L215_D0.9610.97
80_G83_G0.9610.97
209_F243_L0.9610.97
230_L273_L0.9600.97
72_T75_G0.9590.97
217_W225_I0.9550.97
110_T153_D0.9550.97
216_F236_S0.9510.97
103_S235_G0.9490.97
151_K155_D0.9470.97
112_Y117_E0.9440.97
52_Y55_L0.9240.96
122_E188_V0.9200.96
51_R62_E0.9200.96
225_I230_L0.9190.96
10_R13_W0.9130.96
158_L194_Y0.9100.96
8_P49_S0.9000.96
120_K127_E0.8970.95
17_G40_L0.8960.95
128_L204_L0.8920.95
227_F264_Y0.8910.95
146_S149_T0.8900.95
152_R156_C0.8880.95
99_W216_F0.8850.95
225_I275_F0.8700.95
218_E282_P0.8680.95
267_T270_L0.8660.95
212_A236_S0.8660.95
36_A48_K0.8640.94
41_G46_M0.8640.94
19_D23_E0.8620.94
30_V40_L0.8590.94
209_F230_L0.8570.94
71_L75_G0.8540.94
57_F179_L0.8520.94
111_W156_C0.8500.94
74_L96_L0.8490.94
214_L262_I0.8490.94
110_T113_W0.8440.94
6_T150_L0.8440.94
213_L255_L0.8430.94
284_E288_K0.8410.94
196_F201_K0.8390.94
227_F252_L0.8310.93
36_A44_K0.8280.93
160_T179_L0.8270.93
65_K68_G0.8260.93
227_F249_I0.8260.93
215_D219_R0.8260.93
158_L185_I0.8130.92
115_F184_L0.8120.92
266_E271_R0.8060.92
30_V33_D0.8060.92
216_F237_P0.8050.92
85_D98_H0.8030.92
236_S245_E0.8010.92
113_W135_Y0.7990.92
101_L108_A0.7970.92
261_A277_K0.7970.92
252_L273_L0.7960.92
227_F248_L0.7900.91
176_D180_A0.7880.91
251_R254_E0.7870.91
114_F118_F0.7870.91
4_H7_F0.7870.91
145_V153_D0.7860.91
209_F237_P0.7850.91
224_T274_Q0.7840.91
84_W287_E0.7820.91
74_L283_L0.7820.91
275_F279_P0.7820.91
20_A39_R0.7810.91
246_N250_E0.7760.91
2_S6_T0.7720.90
9_L94_L0.7710.90
73_E77_L0.7640.90
207_E258_L0.7620.90
80_G86_P0.7590.90
160_T177_S0.7560.89
211_Y283_L0.7500.89
286_L290_Y0.7480.89
79_F86_P0.7480.89
206_P258_L0.7460.89
132_L136_A0.7450.89
228_E271_R0.7430.89
96_L211_Y0.7410.89
30_V39_R0.7380.88
144_K147_E0.7340.88
243_L248_L0.7330.88
95_W237_P0.7290.88
282_P285_I0.7260.87
37_I209_F0.7260.87
123_F158_L0.7230.87
2_S152_R0.7230.87
237_P261_A0.7180.87
242_K266_E0.7150.87
121_P173_D0.7140.87
224_T272_Q0.7120.86
3_G8_P0.7110.86
201_K204_L0.7110.86
29_N33_D0.7060.86
43_G53_W0.7040.86
96_L241_F0.7010.86
186_R195_R0.6980.85
47_V89_E0.6940.85
55_L62_E0.6940.85
56_A108_A0.6930.85
187_E271_R0.6900.85
52_Y111_W0.6900.85
256_E259_T0.6840.84
129_L151_K0.6840.84
212_A237_P0.6820.84
46_M52_Y0.6810.84
22_K71_L0.6810.84
21_V65_K0.6770.84
109_T153_D0.6690.83
109_T135_Y0.6690.83
11_Y181_E0.6690.83
238_G248_L0.6630.82
40_L46_M0.6620.82
250_E254_E0.6610.82
131_A135_Y0.6580.82
110_T156_C0.6520.81
3_G9_L0.6520.81
17_G90_D0.6490.81
18_Y22_K0.6440.80
125_R154_V0.6440.80
18_Y79_F0.6420.80
61_E151_K0.6420.80
9_L179_L0.6400.80
214_L218_E0.6400.80
227_F271_R0.6380.80
145_V149_T0.6380.80
13_W46_M0.6380.80
143_K262_I0.6380.80
16_K46_M0.6360.80
245_E272_Q0.6350.80
15_K83_G0.6340.79
162_V185_I0.6330.79
7_F43_G0.6310.79
102_A132_L0.6310.79
20_A99_W0.6300.79
87_Y108_A0.6300.79
175_L178_P0.6290.79
2_S8_P0.6250.78
13_W53_W0.6250.78
205_P289_Y0.6250.78
282_P286_L0.6240.78
209_F236_S0.6220.78
201_K247_S0.6210.78
256_E273_L0.6200.78
94_L97_L0.6200.78
99_W103_S0.6190.78
266_E270_L0.6150.77
88_L97_L0.6130.77
124_T193_G0.6130.77
130_E133_K0.6120.77
10_R46_M0.6120.77
226_S229_E0.6110.77
12_G177_S0.6090.77
102_A115_F0.6090.77
11_Y37_I0.6060.76
153_D269_G0.6050.76
63_D68_G0.6040.76
90_D101_L0.6040.76
24_D30_V0.6030.76
13_W16_K0.6010.76
155_D159_R0.6000.76
130_E134_R0.5990.76
62_E69_L0.5990.76
25_P29_N0.5960.75
265_S276_K0.5950.75
46_M53_W0.5950.75
267_T272_Q0.5950.75
116_N238_G0.5940.75
2_S9_L0.5910.75
271_R274_Q0.5900.74
124_T253_E0.5890.74
190_K247_S0.5880.74
163_P200_P0.5880.74
14_L18_Y0.5870.74
201_K242_K0.5840.74
79_F96_L0.5830.74
250_E253_E0.5830.74
35_D38_V0.5820.73
71_L223_G0.5820.73
127_E131_A0.5820.73
88_L178_P0.5810.73
46_M49_S0.5800.73
144_K253_E0.5790.73
188_V195_R0.5780.73
15_K81_D0.5750.73
159_R176_D0.5750.73
155_D164_R0.5740.72
211_Y282_P0.5740.72
116_N235_G0.5720.72
264_Y271_R0.5720.72
11_Y99_W0.5720.72
238_G245_E0.5710.72
222_P262_I0.5700.72
98_H240_V0.5650.71
3_G125_R0.5640.71
46_M56_A0.5640.71
89_E95_W0.5630.71
12_G18_Y0.5630.71
58_G106_E0.5600.71
214_L282_P0.5600.71
129_L133_K0.5600.71
111_W177_S0.5590.70
218_E250_E0.5580.70
49_S53_W0.5570.70
201_K248_L0.5570.70
78_L84_W0.5570.70
116_N149_T0.5570.70
93_T113_W0.5570.70
108_A153_D0.5560.70
261_A276_K0.5540.70
91_P181_E0.5530.70
4_H161_Y0.5520.69
22_K26_D0.5520.69
79_F83_G0.5510.69
65_K263_R0.5500.69
6_T156_C0.5490.69
283_L286_L0.5470.69
61_E257_E0.5470.69
111_W235_G0.5470.69
144_K159_R0.5460.69
239_R265_S0.5460.69
99_W212_A0.5460.69
153_D156_C0.5450.69
123_F185_I0.5430.68
52_Y153_D0.5430.68
255_L259_T0.5420.68
43_G46_M0.5420.68
231_A245_E0.5410.68
247_S251_R0.5410.68
201_K241_F0.5400.68
6_T153_D0.5400.68
183_G197_N0.5400.68
254_E258_L0.5390.68
253_E273_L0.5380.68
90_D273_L0.5370.67
81_D84_W0.5360.67
217_W221_S0.5360.67
38_V50_I0.5350.67
59_L72_T0.5340.67
37_I44_K0.5330.67
6_T117_E0.5330.67
42_V153_D0.5310.67
164_R180_A0.5310.67
277_K283_L0.5300.66
77_L283_L0.5290.66
59_L79_F0.5290.66
146_S152_R0.5290.66
177_S181_E0.5290.66
9_L160_T0.5290.66
61_E73_E0.5270.66
9_L14_L0.5270.66
126_E192_K0.5260.66
92_A101_L0.5260.66
103_S112_Y0.5260.66
146_S175_L0.5250.66
122_E175_L0.5230.65
113_W117_E0.5220.65
99_W241_F0.5210.65
152_R159_R0.5200.65
115_F153_D0.5190.65
197_N226_S0.5190.65
21_V177_S0.5190.65
253_E264_Y0.5190.65
21_V30_V0.5180.65
49_S148_N0.5170.64
127_E227_F0.5150.64
196_F199_G0.5130.64
18_Y54_L0.5130.64
6_T120_K0.5130.64
6_T185_I0.5120.64
121_P188_V0.5110.64
113_W156_C0.5100.63
29_N32_S0.5090.63
4_H45_N0.5080.63
3_G15_K0.5060.63
106_E211_Y0.5060.63
61_E198_R0.5060.63
15_K86_P0.5030.62
166_K262_I0.5030.62
197_N201_K0.5020.62
67_R88_L0.5020.62
262_I275_F0.5020.62
86_P134_R0.5000.62
48_K111_W0.5000.62
54_L59_L0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xmkA 1 0.2655 63.2 0.953 Contact Map
3w6kB 2 0.269 39.5 0.959 Contact Map
1oaoC 1 0.2483 33.6 0.96 Contact Map
2wteA 2 0.2724 33.4 0.96 Contact Map
3w6jB 2 0.2586 30.3 0.961 Contact Map
4i98B 2 0.2517 30 0.961 Contact Map
2pg4A 3 0.3069 25.6 0.963 Contact Map
2xvcA 1 0.1931 24.2 0.963 Contact Map
4p9fA 1 0.2655 23.3 0.963 Contact Map
2h09A 2 0.4207 21.6 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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