GREMLIN Database
DUF3995 - Protein of unknown function (DUF3995)
PFAM: PF13160 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 124 (121)
Sequences: 3205 (2537)
Seq/√Len: 230.6
META: 0.818

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_Y15_G5.8651.00
83_L121_G4.6081.00
9_V45_A3.9081.00
5_A49_L3.2641.00
12_A42_L2.8241.00
108_L112_L2.6101.00
58_L75_G2.4281.00
95_F114_S2.3401.00
37_S40_A2.2781.00
97_K110_T2.2211.00
57_A71_L2.1661.00
2_L52_A2.0841.00
86_G95_F1.9551.00
3_A7_L1.8441.00
4_L48_L1.8441.00
86_G118_L1.7711.00
51_A78_L1.7091.00
82_F120_L1.6191.00
73_L77_A1.6131.00
12_A41_T1.5841.00
107_R111_R1.5641.00
79_A121_G1.5471.00
38_P41_T1.4581.00
54_L74_G1.4561.00
47_L51_A1.4281.00
105_F109_D1.4191.00
119_L123_G1.3971.00
80_A84_L1.3701.00
12_A45_A1.3661.00
109_D114_S1.3611.00
41_T44_V1.3031.00
43_A47_L1.2951.00
14_G17_W1.2921.00
54_L78_L1.2901.00
4_L120_L1.2511.00
106_A109_D1.2501.00
23_A26_V1.2421.00
89_D92_Y1.2211.00
76_W79_A1.2021.00
55_V75_G1.1751.00
97_K100_R1.1581.00
99_V102_T1.1451.00
9_V42_L1.1071.00
86_G114_S1.1021.00
38_P42_L1.0931.00
90_F94_G1.0801.00
94_G97_K1.0771.00
89_D93_V1.0711.00
8_H85_R1.0541.00
37_S41_T1.0461.00
8_H44_V1.0361.00
55_V58_L1.0261.00
15_G18_G1.0261.00
93_V96_F1.0201.00
31_R34_P1.0051.00
108_L113_Y0.9911.00
5_A9_V0.9791.00
117_C120_L0.9771.00
78_L82_F0.9671.00
99_V103_P0.9561.00
2_L49_L0.9501.00
8_H48_L0.9471.00
51_A81_V0.9441.00
9_V49_L0.9321.00
55_V79_A0.9301.00
70_L74_G0.9271.00
116_L120_L0.9231.00
58_L71_L0.9181.00
18_G26_V0.9121.00
44_V48_L0.8940.99
97_K109_D0.8910.99
85_R109_D0.8870.99
56_L61_L0.8850.99
83_L118_L0.8570.99
120_L123_G0.8500.99
46_L50_A0.8410.99
30_A33_G0.8360.99
85_R114_S0.8360.99
108_L111_R0.8350.99
19_L22_L0.8320.99
10_Y13_L0.8190.99
85_R88_G0.8170.99
94_G100_R0.8120.99
42_L45_A0.8060.99
24_D28_P0.8010.99
88_G105_F0.7870.99
96_F99_V0.7770.98
4_L117_C0.7690.98
92_Y99_V0.7690.98
110_T114_S0.7670.98
52_A56_L0.7630.98
69_R73_L0.7600.98
96_F100_R0.7580.98
21_T25_A0.7570.98
58_L72_R0.7520.98
29_T33_G0.7520.98
13_L42_L0.7470.98
5_A45_A0.7450.98
10_Y17_W0.7400.98
22_L28_P0.7370.98
22_L26_V0.7270.98
58_L74_G0.7270.98
4_L8_H0.7230.98
91_R97_K0.7190.97
56_L62_L0.7160.97
85_R105_F0.7130.97
96_F103_P0.7110.97
54_L75_G0.7100.97
10_Y16_T0.7080.97
87_I90_F0.7030.97
72_R75_G0.7000.97
14_G18_G0.6990.97
94_G106_A0.6960.97
25_A108_L0.6950.97
39_A43_A0.6940.97
8_H11_W0.6870.97
74_G78_L0.6850.97
12_A38_P0.6800.96
113_Y120_L0.6730.96
11_W14_G0.6720.96
118_L122_L0.6700.96
30_A92_Y0.6690.96
68_R72_R0.6690.96
103_P108_L0.6670.96
7_L17_W0.6650.96
60_G63_G0.6630.96
64_R67_P0.6580.96
94_G99_V0.6530.96
54_L71_L0.6510.95
71_L75_G0.6490.95
9_V12_A0.6460.95
97_K106_A0.6430.95
19_L25_A0.6390.95
16_T19_L0.6360.95
7_L11_W0.6310.95
52_A55_V0.6280.94
48_L55_V0.6230.94
15_G19_L0.6220.94
95_F118_L0.6220.94
53_L57_A0.6200.94
10_Y19_L0.6200.94
62_L65_P0.6180.94
3_A6_A0.6150.94
24_D32_G0.6140.94
113_Y117_C0.6140.94
86_G89_D0.6080.93
112_L115_P0.6050.93
62_L67_P0.5960.93
65_P71_L0.5890.92
59_A63_G0.5850.92
63_G66_L0.5840.92
25_A28_P0.5820.92
95_F100_R0.5800.92
24_D103_P0.5800.92
18_G113_Y0.5780.92
41_T45_A0.5730.91
8_H105_F0.5670.91
6_A10_Y0.5660.91
89_D114_S0.5600.90
18_G112_L0.5570.90
55_V78_L0.5520.90
82_F116_L0.5520.90
27_V32_G0.5510.90
54_L57_A0.5470.89
65_P70_L0.5470.89
4_L41_T0.5440.89
88_G91_R0.5440.89
7_L36_P0.5430.89
57_A65_P0.5390.89
9_V46_L0.5380.89
94_G98_R0.5380.89
63_G71_L0.5290.88
109_D113_Y0.5290.88
90_F96_F0.5270.88
51_A82_F0.5260.87
77_A80_A0.5140.86
88_G114_S0.5080.86
73_L76_W0.5070.86
48_L85_R0.5040.85
76_W122_L0.5040.85
59_A72_R0.5030.85
106_A110_T0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k1aA 1 0.3387 1.4 0.935 Contact Map
4p02A 1 0.5484 1.4 0.936 Contact Map
1xaxA 1 0.2903 1.3 0.937 Contact Map
2l2tA 2 0.3387 0.8 0.945 Contact Map
1iijA 1 0.2823 0.7 0.946 Contact Map
4djkA 2 0.9274 0.7 0.947 Contact Map
3aofA 1 0.2823 0.7 0.947 Contact Map
1jb0A 1 0.621 0.6 0.95 Contact Map
3rqwA 4 0.6613 0.6 0.95 Contact Map
2kncA 1 0.4355 0.5 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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