GREMLIN Database
DUF3990 - Protein of unknown function (DUF3990)
PFAM: PF13151 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 153 (151)
Sequences: 7359 (4764)
Seq/√Len: 387.7
META: 0.934

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_K39_E3.9571.00
83_D124_K3.1861.00
145_E149_S2.8791.00
33_T138_N2.7021.00
126_E130_R2.6461.00
28_G141_C2.4271.00
123_S126_E2.3931.00
3_L31_T2.3781.00
79_E124_K2.3121.00
21_P27_K2.3101.00
2_I58_V2.2701.00
11_I57_N2.1961.00
7_S57_N2.1661.00
116_L121_I2.0301.00
61_F66_L1.9921.00
102_I140_I1.8851.00
15_D18_K1.8661.00
70_K97_D1.8481.00
31_T142_F1.8461.00
7_S11_I1.8191.00
109_D134_K1.7831.00
2_I60_E1.7561.00
142_F147_A1.7091.00
72_L80_E1.6531.00
34_I137_T1.6511.00
146_K149_S1.6371.00
82_L127_A1.6211.00
86_V118_L1.6201.00
87_A92_K1.6201.00
126_E129_E1.6111.00
113_T127_A1.5801.00
36_E39_E1.5631.00
35_K56_V1.5481.00
39_E43_K1.5471.00
10_I57_N1.5341.00
144_T147_A1.4801.00
102_I138_N1.4801.00
73_R102_I1.4721.00
8_N52_G1.4671.00
79_E125_E1.4501.00
71_I100_I1.4391.00
84_F88_N1.3811.00
60_E152_K1.3791.00
116_L122_I1.3651.00
93_N96_H1.3511.00
3_L140_I1.3321.00
133_F137_T1.3241.00
69_L147_A1.3151.00
65_A150_Y1.3051.00
123_S129_E1.2921.00
36_E40_R1.2731.00
122_I126_E1.2711.00
42_A54_G1.2551.00
72_L98_Y1.2421.00
17_S27_K1.2421.00
39_E56_V1.2371.00
101_V143_K1.2241.00
46_A54_G1.2101.00
96_H143_K1.2091.00
113_T130_R1.2021.00
125_E129_E1.1931.00
142_F151_L1.1811.00
46_A52_G1.1401.00
67_K73_R1.0971.00
35_K58_V1.0911.00
122_I127_A1.0891.00
114_I118_L1.0791.00
71_I102_I1.0651.00
62_D65_A1.0611.00
86_V114_I1.0581.00
16_L148_L1.0511.00
64_D68_D1.0441.00
110_V114_I1.0441.00
1_M60_E1.0301.00
20_R23_K1.0171.00
129_E132_K1.0131.00
70_K98_Y1.0031.00
100_I140_I1.0021.00
74_F84_F0.9951.00
87_A95_G0.9951.00
65_A68_D0.9921.00
113_T122_I0.9911.00
14_P17_S0.9871.00
16_L19_S0.9811.00
79_E83_D0.9621.00
146_K150_Y0.9611.00
112_N116_L0.9591.00
32_T38_A0.9561.00
10_I55_I0.9441.00
113_T116_L0.9411.00
83_D87_A0.9371.00
33_T140_I0.9311.00
91_G94_P0.9251.00
77_Y136_L0.8931.00
127_A131_L0.8891.00
19_S27_K0.8881.00
130_R134_K0.8811.00
31_T140_I0.8641.00
41_W44_R0.8591.00
128_L132_K0.8551.00
19_S23_K0.8411.00
72_L101_V0.8411.00
62_D152_K0.8351.00
63_E66_L0.8341.00
99_D144_T0.8311.00
43_K54_G0.8311.00
8_N45_K0.8291.00
69_L99_D0.8241.00
15_D19_S0.8211.00
37_Q105_V0.8201.00
33_T102_I0.8071.00
9_V12_E0.8041.00
45_K48_R0.7831.00
64_D67_K0.7791.00
82_L113_T0.7791.00
84_F143_K0.7761.00
8_N46_A0.7751.00
22_N91_G0.7711.00
4_Y35_K0.7711.00
109_D112_N0.7701.00
86_V117_Y0.7701.00
127_A130_R0.7671.00
52_G55_I0.7671.00
61_F142_F0.7671.00
43_K46_A0.7651.00
99_D146_K0.7651.00
92_K95_G0.7651.00
115_Q119_D0.7581.00
116_L119_D0.7571.00
114_I127_A0.7531.00
111_F118_L0.7471.00
117_Y124_K0.7361.00
148_L151_L0.7351.00
15_D20_R0.7341.00
63_E73_R0.7341.00
80_E83_D0.7191.00
88_N95_G0.7191.00
122_I130_R0.7071.00
15_D27_K0.7061.00
38_A56_V0.7041.00
77_Y133_F0.7041.00
69_L144_T0.7021.00
149_S152_K0.6971.00
112_N121_I0.6940.99
75_D78_D0.6900.99
110_V141_C0.6830.99
41_W45_K0.6800.99
83_D117_Y0.6790.99
69_L150_Y0.6780.99
32_T105_V0.6720.99
49_R52_G0.6710.99
81_W106_A0.6640.99
116_L130_R0.6620.99
6_G56_V0.6570.99
84_F95_G0.6510.99
111_F117_Y0.6470.99
100_I147_A0.6470.99
48_R51_G0.6440.99
82_L86_V0.6420.99
44_R109_D0.6380.99
9_V13_K0.6370.99
87_A93_N0.6340.99
78_D131_L0.6320.99
87_A94_P0.6310.99
66_L71_I0.6310.99
111_F134_K0.6310.99
82_L124_K0.6120.99
62_D66_L0.6110.99
7_S10_I0.6040.99
70_K96_H0.6020.99
86_V121_I0.6020.99
142_F148_L0.6000.99
77_Y128_L0.5990.99
18_K27_K0.5980.98
88_N94_P0.5980.98
69_L98_Y0.5910.98
77_Y80_E0.5900.98
13_K149_S0.5890.98
94_P97_D0.5860.98
10_I14_P0.5840.98
132_K135_K0.5820.98
40_R43_K0.5820.98
103_G108_D0.5810.98
107_N113_T0.5810.98
14_P57_N0.5800.98
110_V133_F0.5730.98
68_D71_I0.5700.98
70_K99_D0.5640.98
61_F100_I0.5610.98
111_F130_R0.5580.98
108_D117_Y0.5580.98
87_A91_G0.5560.98
31_T141_C0.5550.98
112_N115_Q0.5550.98
111_F115_Q0.5510.97
145_E148_L0.5510.97
11_I14_P0.5470.97
105_V137_T0.5470.97
114_I131_L0.5460.97
61_F64_D0.5420.97
85_V114_I0.5410.97
106_A136_L0.5410.97
110_V134_K0.5390.97
108_D113_T0.5390.97
42_A56_V0.5380.97
37_Q138_N0.5370.97
124_K127_A0.5350.97
68_D150_Y0.5330.97
112_N130_R0.5310.97
6_G41_W0.5300.97
34_I138_N0.5300.97
107_N111_F0.5280.97
6_G57_N0.5270.97
128_L131_L0.5220.96
23_K111_F0.5220.96
61_F150_Y0.5180.96
14_P148_L0.5170.96
12_E59_Y0.5160.96
77_Y104_P0.5160.96
84_F101_V0.5140.96
49_R53_K0.5140.96
13_K17_S0.5100.96
95_G143_K0.5080.96
40_R109_D0.5070.96
109_D116_L0.5040.96
16_L144_T0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2x5yA 1 0.6993 88.1 0.884 Contact Map
2pqfA 2 0.732 87.9 0.884 Contact Map
3smjA 2 0.7451 85.2 0.889 Contact Map
3bljA 1 0.7451 84.7 0.889 Contact Map
4pnlA 1 0.7778 82.1 0.893 Contact Map
4bueA 1 0.6928 78.1 0.897 Contact Map
4f0dA 1 0.549 76.1 0.899 Contact Map
3kjdA 1 0.7582 68.7 0.904 Contact Map
1efyA 1 0.7712 67.3 0.905 Contact Map
3hkvA 2 0.7582 61.7 0.908 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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